Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study
The prevalence rate of hyperuricemia remains high in Taiwan, at 21.6% in men and 9.57% in women. Both metabolic syndrome (MetS) and hyperuricemia can cause many complications; however, few studies have evaluated the correlation between MetS and hyperuricemia. Therefore, in this observational cohort...
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MDPI AG
2023-02-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/5/1083 |
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| author | Yen-Chieh Tu Yi-Hsueh Liu Szu-Chia Chen Ho-Ming Su |
| author_facet | Yen-Chieh Tu Yi-Hsueh Liu Szu-Chia Chen Ho-Ming Su |
| author_sort | Yen-Chieh Tu |
| collection | DOAJ |
| description | The prevalence rate of hyperuricemia remains high in Taiwan, at 21.6% in men and 9.57% in women. Both metabolic syndrome (MetS) and hyperuricemia can cause many complications; however, few studies have evaluated the correlation between MetS and hyperuricemia. Therefore, in this observational cohort study, we explored associations between metabolic syndrome (MetS) and its components and new-onset hyperuricemia. Of 27,033 individuals in the Taiwan Biobank who had complete follow-up data, we excluded those with hyperuricemia at baseline (<i>n</i> = 4871), those with gout at baseline (<i>n</i> = 1043), those with no data on baseline uric acid (<i>n</i> = 18), and those with no data on follow-up uric acid (<i>n</i> = 71). The remaining 21,030 participants (mean age 50.8 ± 10.3 years) were enrolled. We found a significant association between new-onset hyperuricemia with MetS and the components of MetS (hypertriglyceridemia, abdominal obesity, low high-density lipoprotein cholesterol, hyperglycemia, and high blood pressure). Furthermore, compared to those without any MetS components, those with one MetS component (OR = 1.816), two MetS components (OR = 2.727), three MetS components (OR = 3.208), four MetS components (OR = 4.256), and five MetS components (OR = 5.282) were significantly associated with new-onset hyperuricemia (all <i>p</i> < 0.001). MetS and its five components were associated with new-onset hyperuricemia in the enrolled participants. Further, an increase in the number of MetS components was associated with an increase in the incidence rate of new-onset hyperuricemia. |
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| language | English |
| last_indexed | 2024-03-11T07:15:19Z |
| publishDate | 2023-02-01 |
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| series | Nutrients |
| spelling | doaj.art-2ed18e90eaa54bf790dc2a30b3d631da2023-11-17T08:19:21ZengMDPI AGNutrients2072-66432023-02-01155108310.3390/nu15051083Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up StudyYen-Chieh Tu0Yi-Hsueh Liu1Szu-Chia Chen2Ho-Ming Su3Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanThe prevalence rate of hyperuricemia remains high in Taiwan, at 21.6% in men and 9.57% in women. Both metabolic syndrome (MetS) and hyperuricemia can cause many complications; however, few studies have evaluated the correlation between MetS and hyperuricemia. Therefore, in this observational cohort study, we explored associations between metabolic syndrome (MetS) and its components and new-onset hyperuricemia. Of 27,033 individuals in the Taiwan Biobank who had complete follow-up data, we excluded those with hyperuricemia at baseline (<i>n</i> = 4871), those with gout at baseline (<i>n</i> = 1043), those with no data on baseline uric acid (<i>n</i> = 18), and those with no data on follow-up uric acid (<i>n</i> = 71). The remaining 21,030 participants (mean age 50.8 ± 10.3 years) were enrolled. We found a significant association between new-onset hyperuricemia with MetS and the components of MetS (hypertriglyceridemia, abdominal obesity, low high-density lipoprotein cholesterol, hyperglycemia, and high blood pressure). Furthermore, compared to those without any MetS components, those with one MetS component (OR = 1.816), two MetS components (OR = 2.727), three MetS components (OR = 3.208), four MetS components (OR = 4.256), and five MetS components (OR = 5.282) were significantly associated with new-onset hyperuricemia (all <i>p</i> < 0.001). MetS and its five components were associated with new-onset hyperuricemia in the enrolled participants. Further, an increase in the number of MetS components was associated with an increase in the incidence rate of new-onset hyperuricemia.https://www.mdpi.com/2072-6643/15/5/1083follow-upTaiwan Biobankhyperuricemiametabolic syndromemetabolic syndrome components |
| spellingShingle | Yen-Chieh Tu Yi-Hsueh Liu Szu-Chia Chen Ho-Ming Su Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study Nutrients follow-up Taiwan Biobank hyperuricemia metabolic syndrome metabolic syndrome components |
| title | Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study |
| title_full | Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study |
| title_fullStr | Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study |
| title_full_unstemmed | Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study |
| title_short | Metabolic Syndrome and Its Components Are Associated with New-Onset Hyperuricemia in a Large Taiwanese Population Follow-Up Study |
| title_sort | metabolic syndrome and its components are associated with new onset hyperuricemia in a large taiwanese population follow up study |
| topic | follow-up Taiwan Biobank hyperuricemia metabolic syndrome metabolic syndrome components |
| url | https://www.mdpi.com/2072-6643/15/5/1083 |
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