The role of proteasomes in tumorigenesis
Protein homeostasis is the basis of normal life activities, and the proteasome family plays an extremely important function in this process. The proteasome 20S is a concentric circle structure with two α rings and two β rings overlapped. The proteasome 20S can perform both ATP-dependent and non-ATP-...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-07-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304223003525 |
| _version_ | 1827257162519281664 |
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| author | Xiangyi Zhou Ruqing Xu Yue Wu Li Zhou Tingxiu Xiang |
| author_facet | Xiangyi Zhou Ruqing Xu Yue Wu Li Zhou Tingxiu Xiang |
| author_sort | Xiangyi Zhou |
| collection | DOAJ |
| description | Protein homeostasis is the basis of normal life activities, and the proteasome family plays an extremely important function in this process. The proteasome 20S is a concentric circle structure with two α rings and two β rings overlapped. The proteasome 20S can perform both ATP-dependent and non-ATP-dependent ubiquitination proteasome degradation by binding to various subunits (such as 19S, 11S, and 200 PA), which is performed by its active subunit β1, β2, and β5. The proteasome can degrade misfolded, excess proteins to maintain homeostasis. At the same time, it can be utilized by tumors to degrade over-proliferate and unwanted proteins to support their growth. Proteasomes can affect the development of tumors from several aspects including tumor signaling pathways such as NF-κB and p53, cell cycle, immune regulation, and drug resistance. Proteasome-encoding genes have been found to be overexpressed in a variety of tumors, providing a potential novel target for cancer therapy. In addition, proteasome inhibitors such as bortezomib, carfilzomib, and ixazomib have been put into clinical application as the first-line treatment of multiple myeloma. More and more studies have shown that it also has different therapeutic effects in other tumors such as hepatocellular carcinoma, non-small cell lung cancer, glioblastoma, and neuroblastoma. However, proteasome inhibitors are not much effective due to their tolerance and singleness in other tumors. Therefore, further studies on their mechanisms of action and drug interactions are needed to investigate their therapeutic potential. |
| first_indexed | 2024-04-24T23:17:02Z |
| format | Article |
| id | doaj.art-2ed222aca2884ec1bad619ea4714c70c |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T01:50:25Z |
| publishDate | 2024-07-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-2ed222aca2884ec1bad619ea4714c70c2024-05-08T04:07:29ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422024-07-01114101070The role of proteasomes in tumorigenesisXiangyi Zhou0Ruqing Xu1Yue Wu2Li Zhou3Tingxiu Xiang4Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, ChinaDepartment of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaDepartment of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, ChinaChongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China; Corresponding author.Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, China; Corresponding author. Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.Protein homeostasis is the basis of normal life activities, and the proteasome family plays an extremely important function in this process. The proteasome 20S is a concentric circle structure with two α rings and two β rings overlapped. The proteasome 20S can perform both ATP-dependent and non-ATP-dependent ubiquitination proteasome degradation by binding to various subunits (such as 19S, 11S, and 200 PA), which is performed by its active subunit β1, β2, and β5. The proteasome can degrade misfolded, excess proteins to maintain homeostasis. At the same time, it can be utilized by tumors to degrade over-proliferate and unwanted proteins to support their growth. Proteasomes can affect the development of tumors from several aspects including tumor signaling pathways such as NF-κB and p53, cell cycle, immune regulation, and drug resistance. Proteasome-encoding genes have been found to be overexpressed in a variety of tumors, providing a potential novel target for cancer therapy. In addition, proteasome inhibitors such as bortezomib, carfilzomib, and ixazomib have been put into clinical application as the first-line treatment of multiple myeloma. More and more studies have shown that it also has different therapeutic effects in other tumors such as hepatocellular carcinoma, non-small cell lung cancer, glioblastoma, and neuroblastoma. However, proteasome inhibitors are not much effective due to their tolerance and singleness in other tumors. Therefore, further studies on their mechanisms of action and drug interactions are needed to investigate their therapeutic potential.http://www.sciencedirect.com/science/article/pii/S2352304223003525BortezomibCancer therapyImmunoproteasomeMultiple myelomaProteasome 20SProteasome inhibitor |
| spellingShingle | Xiangyi Zhou Ruqing Xu Yue Wu Li Zhou Tingxiu Xiang The role of proteasomes in tumorigenesis Genes and Diseases Bortezomib Cancer therapy Immunoproteasome Multiple myeloma Proteasome 20S Proteasome inhibitor |
| title | The role of proteasomes in tumorigenesis |
| title_full | The role of proteasomes in tumorigenesis |
| title_fullStr | The role of proteasomes in tumorigenesis |
| title_full_unstemmed | The role of proteasomes in tumorigenesis |
| title_short | The role of proteasomes in tumorigenesis |
| title_sort | role of proteasomes in tumorigenesis |
| topic | Bortezomib Cancer therapy Immunoproteasome Multiple myeloma Proteasome 20S Proteasome inhibitor |
| url | http://www.sciencedirect.com/science/article/pii/S2352304223003525 |
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