Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial
Cancer patients have a 2 times higher prevalence of insomnia than healthy populations and cancer-related insomnia has received minimal attention while insomnia can aggravate the rehabilitation of cancer patients. Cheonwangbosimdan is a Korean herbal medicine generally used to relieve sleep deprivati...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2020-07-01
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| Series: | Integrative Cancer Therapies |
| Online Access: | https://doi.org/10.1177/1534735420935643 |
| _version_ | 1830403429439111168 |
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| author | Sun-Young Moon KMD, BS Ui Min Jerng KMD, PhD O-Jin Kwon PhD So-Young Jung BS Jee Young Lee KMD Seong Woo Yoon KMD, PhD Won-Chul Shin MD, PhD Jung-Ick Byun MD, PhD Jun-Hwan Lee KMD, PhD |
| author_facet | Sun-Young Moon KMD, BS Ui Min Jerng KMD, PhD O-Jin Kwon PhD So-Young Jung BS Jee Young Lee KMD Seong Woo Yoon KMD, PhD Won-Chul Shin MD, PhD Jung-Ick Byun MD, PhD Jun-Hwan Lee KMD, PhD |
| author_sort | Sun-Young Moon KMD, BS |
| collection | DOAJ |
| description | Cancer patients have a 2 times higher prevalence of insomnia than healthy populations and cancer-related insomnia has received minimal attention while insomnia can aggravate the rehabilitation of cancer patients. Cheonwangbosimdan is a Korean herbal medicine generally used to relieve sleep deprivation, however, few studies presented the effects of Cheonwangbosimdan on cancer-related insomnia. The purpose of study is to examine the feasibility of Cheonwangbosimdan treatments for cancer patients. Twenty-two participants were allocated into a Cheonwangbosimdan or cognitive-behavioral therapy for insomnia (CBT-I) control group by equal number. The intervention group took Cheonwangbosimdan liquid once in a day and attend visits once a week for 4 weeks. The CBT-I group underwent individualized behavioral therapy 4 times in 4 weeks. The primary outcome is changes in the Insomnia Severity Index (ISI) from baseline to the end of the trial. Responses to the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Zung Self-Rating Anxiety Scale (SAS), Brief Fatigue Inventory (BFI), Euroqol-5 Dimensions-5 Levels (EQ-5D-5L), and Eastern Cooperative Oncology Group Performance Status (ECOG-PS) were secondary outcomes used to evaluate the quality of sleep. Outcomes were measured at a follow-up visit (visit 5) in the fifth week of the trial. There is no difference between 2 groups, but both groups showed tendency to alleviate cancer insomnia symptoms. SAS-K showed significant difference between the 2 groups (P < .001), as treatment group score was highly lowered than control group score. The study can contribute to more attentive care for insomnia in cancer patients. |
| first_indexed | 2024-12-20T17:09:22Z |
| format | Article |
| id | doaj.art-2ed2d50de1dd409bb90acf02e97422db |
| institution | Directory Open Access Journal |
| issn | 1534-7354 1552-695X |
| language | English |
| last_indexed | 2024-12-20T17:09:22Z |
| publishDate | 2020-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Integrative Cancer Therapies |
| spelling | doaj.art-2ed2d50de1dd409bb90acf02e97422db2022-12-21T19:32:11ZengSAGE PublishingIntegrative Cancer Therapies1534-73541552-695X2020-07-011910.1177/1534735420935643Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot TrialSun-Young Moon KMD, BS0Ui Min Jerng KMD, PhD1O-Jin Kwon PhD2So-Young Jung BS3Jee Young Lee KMD4Seong Woo Yoon KMD, PhD5Won-Chul Shin MD, PhD6Jung-Ick Byun MD, PhD7Jun-Hwan Lee KMD, PhD8University of Science and Technology (UST), Campus of Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaSang-ji University Korean Medicine Hospital, Wonju, Republic of KoreaKorea Institute of Oriental Medicine, Daejeon, Republic of KoreaKorea Institute of Oriental Medicine, Daejeon, Republic of KoreaKyung Hee University, Seoul, Republic of KoreaKyung Hee University, Seoul, Republic of KoreaKyung Hee University Hospital at Gangdong, Seoul, Republic of KoreaKyung Hee University Hospital at Gangdong, Seoul, Republic of KoreaUniversity of Science and Technology (UST), Campus of Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaCancer patients have a 2 times higher prevalence of insomnia than healthy populations and cancer-related insomnia has received minimal attention while insomnia can aggravate the rehabilitation of cancer patients. Cheonwangbosimdan is a Korean herbal medicine generally used to relieve sleep deprivation, however, few studies presented the effects of Cheonwangbosimdan on cancer-related insomnia. The purpose of study is to examine the feasibility of Cheonwangbosimdan treatments for cancer patients. Twenty-two participants were allocated into a Cheonwangbosimdan or cognitive-behavioral therapy for insomnia (CBT-I) control group by equal number. The intervention group took Cheonwangbosimdan liquid once in a day and attend visits once a week for 4 weeks. The CBT-I group underwent individualized behavioral therapy 4 times in 4 weeks. The primary outcome is changes in the Insomnia Severity Index (ISI) from baseline to the end of the trial. Responses to the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Zung Self-Rating Anxiety Scale (SAS), Brief Fatigue Inventory (BFI), Euroqol-5 Dimensions-5 Levels (EQ-5D-5L), and Eastern Cooperative Oncology Group Performance Status (ECOG-PS) were secondary outcomes used to evaluate the quality of sleep. Outcomes were measured at a follow-up visit (visit 5) in the fifth week of the trial. There is no difference between 2 groups, but both groups showed tendency to alleviate cancer insomnia symptoms. SAS-K showed significant difference between the 2 groups (P < .001), as treatment group score was highly lowered than control group score. The study can contribute to more attentive care for insomnia in cancer patients.https://doi.org/10.1177/1534735420935643 |
| spellingShingle | Sun-Young Moon KMD, BS Ui Min Jerng KMD, PhD O-Jin Kwon PhD So-Young Jung BS Jee Young Lee KMD Seong Woo Yoon KMD, PhD Won-Chul Shin MD, PhD Jung-Ick Byun MD, PhD Jun-Hwan Lee KMD, PhD Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial Integrative Cancer Therapies |
| title | Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial |
| title_full | Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial |
| title_fullStr | Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial |
| title_full_unstemmed | Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial |
| title_short | Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial |
| title_sort | comparative effectiveness of cheonwangbosimdan tian wang bu xin dan versus cognitive behavioral therapy for insomnia in cancer patients a randomized controlled open label parallel group pilot trial |
| url | https://doi.org/10.1177/1534735420935643 |
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