Stereotactic Radiofrequency Ablation of Liver Tumors in Octogenarians
Purpose: This study aimed to evaluate the efficacy and overall clinical outcome of patients over the age of 80 undergoing stereotactic radiofrequency ablation (SRFA) and to compare the results to a younger population with propensity score matching.Materials and Methods: Between 2006 and 2018 36 pati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00929/full |
| _version_ | 1819130630626082816 |
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| author | Peter Schullian Daniel Putzer Michael A. Silva Gregor Laimer Christian Kolbitsch Reto Bale |
| author_facet | Peter Schullian Daniel Putzer Michael A. Silva Gregor Laimer Christian Kolbitsch Reto Bale |
| author_sort | Peter Schullian |
| collection | DOAJ |
| description | Purpose: This study aimed to evaluate the efficacy and overall clinical outcome of patients over the age of 80 undergoing stereotactic radiofrequency ablation (SRFA) and to compare the results to a younger population with propensity score matching.Materials and Methods: Between 2006 and 2018 36 patients aged between 80 and 90 years underwent 46 SRFA sessions of 70 primary and secondary liver tumors. For comparison of treatment safety and efficacy 36 younger patients were selected with propensity score matching by the R package “MatchIt” in this retrospective, single-center study.Results: 68/70 tumors were successfully ablated at first ablation session (97% primary technical efficacy rate). Local tumor recurrence developed in 5 of 70 nodules (7.1%). The complication rate above Clavien-Dindo Grade III was 6.5% (3 of 46). The overall survival (OS) rates at 1-, 3-, and 5- years from the date of the first SRFA were 84.6, 50.5, and 37.9% for HCC patients and 87.5%, 52.5% at 1-, and 3-years for CRC patients. The disease-free survival (DFS) for HCC patients after SRFA was 79.1, 35.6, and 23.7%, at 1-, 3-, and 5- years, and 75%, 22.5% at 1-, and 3-years for CRC patients. There were no significant differences in terms of technical efficacy, local recurrences, major complications, OS and DFS compared to the control group.Conclusion: SRFA in octogenarians is a safe, feasible and useful option in the management of primary or metastatic liver tumors with no significant difference in outcomes compared to a younger control group. |
| first_indexed | 2024-12-22T09:02:40Z |
| format | Article |
| id | doaj.art-2ed4c185b3944c819a1a941f433155c1 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T09:02:40Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-2ed4c185b3944c819a1a941f433155c12022-12-21T18:31:41ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-09-01910.3389/fonc.2019.00929483139Stereotactic Radiofrequency Ablation of Liver Tumors in OctogenariansPeter Schullian0Daniel Putzer1Michael A. Silva2Gregor Laimer3Christian Kolbitsch4Reto Bale5Section of Interventional Oncology - Microinvasive Therapy, Department of Radiology, Medical University of Innsbruck, Innsbruck, AustriaSection of Interventional Oncology - Microinvasive Therapy, Department of Radiology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Hepatobiliary and Pancreatic Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, United KingdomSection of Interventional Oncology - Microinvasive Therapy, Department of Radiology, Medical University of Innsbruck, Innsbruck, AustriaDepartment of Anesthesia, Medical University of Innsbruck, Innsbruck, AustriaSection of Interventional Oncology - Microinvasive Therapy, Department of Radiology, Medical University of Innsbruck, Innsbruck, AustriaPurpose: This study aimed to evaluate the efficacy and overall clinical outcome of patients over the age of 80 undergoing stereotactic radiofrequency ablation (SRFA) and to compare the results to a younger population with propensity score matching.Materials and Methods: Between 2006 and 2018 36 patients aged between 80 and 90 years underwent 46 SRFA sessions of 70 primary and secondary liver tumors. For comparison of treatment safety and efficacy 36 younger patients were selected with propensity score matching by the R package “MatchIt” in this retrospective, single-center study.Results: 68/70 tumors were successfully ablated at first ablation session (97% primary technical efficacy rate). Local tumor recurrence developed in 5 of 70 nodules (7.1%). The complication rate above Clavien-Dindo Grade III was 6.5% (3 of 46). The overall survival (OS) rates at 1-, 3-, and 5- years from the date of the first SRFA were 84.6, 50.5, and 37.9% for HCC patients and 87.5%, 52.5% at 1-, and 3-years for CRC patients. The disease-free survival (DFS) for HCC patients after SRFA was 79.1, 35.6, and 23.7%, at 1-, 3-, and 5- years, and 75%, 22.5% at 1-, and 3-years for CRC patients. There were no significant differences in terms of technical efficacy, local recurrences, major complications, OS and DFS compared to the control group.Conclusion: SRFA in octogenarians is a safe, feasible and useful option in the management of primary or metastatic liver tumors with no significant difference in outcomes compared to a younger control group.https://www.frontiersin.org/article/10.3389/fonc.2019.00929/fullradiofrequency ablationoctogenarianlivertumorstereotaxy |
| spellingShingle | Peter Schullian Daniel Putzer Michael A. Silva Gregor Laimer Christian Kolbitsch Reto Bale Stereotactic Radiofrequency Ablation of Liver Tumors in Octogenarians Frontiers in Oncology radiofrequency ablation octogenarian liver tumor stereotaxy |
| title | Stereotactic Radiofrequency Ablation of Liver Tumors in Octogenarians |
| title_full | Stereotactic Radiofrequency Ablation of Liver Tumors in Octogenarians |
| title_fullStr | Stereotactic Radiofrequency Ablation of Liver Tumors in Octogenarians |
| title_full_unstemmed | Stereotactic Radiofrequency Ablation of Liver Tumors in Octogenarians |
| title_short | Stereotactic Radiofrequency Ablation of Liver Tumors in Octogenarians |
| title_sort | stereotactic radiofrequency ablation of liver tumors in octogenarians |
| topic | radiofrequency ablation octogenarian liver tumor stereotaxy |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00929/full |
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