Aquaporins in Renal Diseases
Aquaporins (AQPs) are a family of highly selective transmembrane channels that mainly transport water across the cell and some facilitate low-molecular-weight solutes. Eight AQPs, including AQP1, AQP2, AQP3, AQP4, AQP5, AQP6, AQP7, and AQP11, are expressed in different segments and various cells in...
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| Format: | Article |
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MDPI AG
2019-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/20/2/366 |
| _version_ | 1811268563139297280 |
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| author | Jinzhao He Baoxue Yang |
| author_facet | Jinzhao He Baoxue Yang |
| author_sort | Jinzhao He |
| collection | DOAJ |
| description | Aquaporins (AQPs) are a family of highly selective transmembrane channels that mainly transport water across the cell and some facilitate low-molecular-weight solutes. Eight AQPs, including AQP1, AQP2, AQP3, AQP4, AQP5, AQP6, AQP7, and AQP11, are expressed in different segments and various cells in the kidney to maintain normal urine concentration function. AQP2 is critical in regulating urine concentrating ability. The expression and function of AQP2 are regulated by a series of transcriptional factors and post-transcriptional phosphorylation, ubiquitination, and glycosylation. Mutation or functional deficiency of AQP2 leads to severe nephrogenic diabetes insipidus. Studies with animal models show AQPs are related to acute kidney injury and various chronic kidney diseases, such as diabetic nephropathy, polycystic kidney disease, and renal cell carcinoma. Experimental data suggest ideal prospects for AQPs as biomarkers and therapeutic targets in clinic. This review article mainly focuses on recent advances in studying AQPs in renal diseases. |
| first_indexed | 2024-04-12T21:24:29Z |
| format | Article |
| id | doaj.art-2ed5537e25ca460fa0048c754fa8532c |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T21:24:29Z |
| publishDate | 2019-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2ed5537e25ca460fa0048c754fa8532c2022-12-22T03:16:12ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-01-0120236610.3390/ijms20020366ijms20020366Aquaporins in Renal DiseasesJinzhao He0Baoxue Yang1State Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100038, ChinaState Key Laboratory of Natural and Biomimetic Drugs, Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100038, ChinaAquaporins (AQPs) are a family of highly selective transmembrane channels that mainly transport water across the cell and some facilitate low-molecular-weight solutes. Eight AQPs, including AQP1, AQP2, AQP3, AQP4, AQP5, AQP6, AQP7, and AQP11, are expressed in different segments and various cells in the kidney to maintain normal urine concentration function. AQP2 is critical in regulating urine concentrating ability. The expression and function of AQP2 are regulated by a series of transcriptional factors and post-transcriptional phosphorylation, ubiquitination, and glycosylation. Mutation or functional deficiency of AQP2 leads to severe nephrogenic diabetes insipidus. Studies with animal models show AQPs are related to acute kidney injury and various chronic kidney diseases, such as diabetic nephropathy, polycystic kidney disease, and renal cell carcinoma. Experimental data suggest ideal prospects for AQPs as biomarkers and therapeutic targets in clinic. This review article mainly focuses on recent advances in studying AQPs in renal diseases.http://www.mdpi.com/1422-0067/20/2/366aquaporinvasopressinnephrogenic diabetes insipidusacute kidney injurydiabetic nephropathypolycystic kidney diseaserenal cell carcinoma |
| spellingShingle | Jinzhao He Baoxue Yang Aquaporins in Renal Diseases International Journal of Molecular Sciences aquaporin vasopressin nephrogenic diabetes insipidus acute kidney injury diabetic nephropathy polycystic kidney disease renal cell carcinoma |
| title | Aquaporins in Renal Diseases |
| title_full | Aquaporins in Renal Diseases |
| title_fullStr | Aquaporins in Renal Diseases |
| title_full_unstemmed | Aquaporins in Renal Diseases |
| title_short | Aquaporins in Renal Diseases |
| title_sort | aquaporins in renal diseases |
| topic | aquaporin vasopressin nephrogenic diabetes insipidus acute kidney injury diabetic nephropathy polycystic kidney disease renal cell carcinoma |
| url | http://www.mdpi.com/1422-0067/20/2/366 |
| work_keys_str_mv | AT jinzhaohe aquaporinsinrenaldiseases AT baoxueyang aquaporinsinrenaldiseases |