<i>Streptococcus mitis</i> as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic Review
<i>Streptococcus mitis</i>, a normal inhabitant of the oral cavity, is a member of Viridans Group Streptococci (VGS). Generally recognized as a causative agent of invasive diseases in immunocompromised patients, <i>S. mitis</i> is considered to have low pathogenic potential i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/7/1222 |
| _version_ | 1797590498359115776 |
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| author | Claudia Colomba Valeria Garbo Giovanni Boncori Chiara Albano Sara Bagarello Anna Condemi Salvatore Giordano Laura A. Canduscio Cristina Gallo Gaspare Parrinello Antonio Cascio |
| author_facet | Claudia Colomba Valeria Garbo Giovanni Boncori Chiara Albano Sara Bagarello Anna Condemi Salvatore Giordano Laura A. Canduscio Cristina Gallo Gaspare Parrinello Antonio Cascio |
| author_sort | Claudia Colomba |
| collection | DOAJ |
| description | <i>Streptococcus mitis</i>, a normal inhabitant of the oral cavity, is a member of Viridans Group Streptococci (VGS). Generally recognized as a causative agent of invasive diseases in immunocompromised patients, <i>S. mitis</i> is considered to have low pathogenic potential in immunocompetent individuals. We present a rare case of sinusitis complicated by meningitis and cerebral sino-venous thrombosis (CSVT) caused by <i>S. mitis</i> in a previously healthy 12-year-old boy with poor oral health status. With the aim of understanding the real pathogenic role of this microorganism, an extensive review of the literature about invasive diseases due to <i>S. mitis</i> in pediatric patients was performed. Our data define the critical role of this microorganism in invasive infections, especially in immunocompetent children and in the presence of apparently harmful conditions such as sinusitis and caries. Attention should be paid to the choice of therapy because of VGS’s emerging antimicrobial resistance patterns. |
| first_indexed | 2024-03-11T01:21:22Z |
| format | Article |
| id | doaj.art-2ed63a12c6f9444b9cd958ee8786d92b |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T01:21:22Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-2ed63a12c6f9444b9cd958ee8786d92b2023-11-18T18:04:00ZengMDPI AGAntibiotics2079-63822023-07-01127122210.3390/antibiotics12071222<i>Streptococcus mitis</i> as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic ReviewClaudia Colomba0Valeria Garbo1Giovanni Boncori2Chiara Albano3Sara Bagarello4Anna Condemi5Salvatore Giordano6Laura A. Canduscio7Cristina Gallo8Gaspare Parrinello9Antonio Cascio10Department of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, ItalyDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, ItalyDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, ItalyDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, ItalyDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, ItalyDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, ItalyDivision of Pediatric Infectious Diseases, “G. Di Cristina” Hospital, ARNAS Civico Di Cristina Benfratelli, 90100 Palermo, ItalyDivision of Pediatric Infectious Diseases, “G. Di Cristina” Hospital, ARNAS Civico Di Cristina Benfratelli, 90100 Palermo, ItalyDivision of Radiology, “G. Di Cristina” Hospital, ARNAS Civico Di Cristina Benfratelli, 90100 Palermo, ItalyDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, ItalyDepartment of Health Promotion, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, 90100 Palermo, Italy<i>Streptococcus mitis</i>, a normal inhabitant of the oral cavity, is a member of Viridans Group Streptococci (VGS). Generally recognized as a causative agent of invasive diseases in immunocompromised patients, <i>S. mitis</i> is considered to have low pathogenic potential in immunocompetent individuals. We present a rare case of sinusitis complicated by meningitis and cerebral sino-venous thrombosis (CSVT) caused by <i>S. mitis</i> in a previously healthy 12-year-old boy with poor oral health status. With the aim of understanding the real pathogenic role of this microorganism, an extensive review of the literature about invasive diseases due to <i>S. mitis</i> in pediatric patients was performed. Our data define the critical role of this microorganism in invasive infections, especially in immunocompetent children and in the presence of apparently harmful conditions such as sinusitis and caries. Attention should be paid to the choice of therapy because of VGS’s emerging antimicrobial resistance patterns.https://www.mdpi.com/2079-6382/12/7/1222VGS<i>S. mitis</i>pediatricinvasive disease |
| spellingShingle | Claudia Colomba Valeria Garbo Giovanni Boncori Chiara Albano Sara Bagarello Anna Condemi Salvatore Giordano Laura A. Canduscio Cristina Gallo Gaspare Parrinello Antonio Cascio <i>Streptococcus mitis</i> as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic Review Antibiotics VGS <i>S. mitis</i> pediatric invasive disease |
| title | <i>Streptococcus mitis</i> as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic Review |
| title_full | <i>Streptococcus mitis</i> as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic Review |
| title_fullStr | <i>Streptococcus mitis</i> as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic Review |
| title_full_unstemmed | <i>Streptococcus mitis</i> as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic Review |
| title_short | <i>Streptococcus mitis</i> as a New Emerging Pathogen in Pediatric Age: Case Report and Systematic Review |
| title_sort | i streptococcus mitis i as a new emerging pathogen in pediatric age case report and systematic review |
| topic | VGS <i>S. mitis</i> pediatric invasive disease |
| url | https://www.mdpi.com/2079-6382/12/7/1222 |
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