Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease?
The increase in the life expectancy average has led to a growing elderly population, thus leading to a prevalence of neurodegenerative disorders, such as Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder and is characterized by a progressive degeneration of the dopami...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/21/8/451 |
| _version_ | 1827729324211437568 |
|---|---|
| author | Joana Silva Celso Alves Francisca Soledade Alice Martins Susete Pinteus Helena Gaspar Amparo Alfonso Rui Pedrosa |
| author_facet | Joana Silva Celso Alves Francisca Soledade Alice Martins Susete Pinteus Helena Gaspar Amparo Alfonso Rui Pedrosa |
| author_sort | Joana Silva |
| collection | DOAJ |
| description | The increase in the life expectancy average has led to a growing elderly population, thus leading to a prevalence of neurodegenerative disorders, such as Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder and is characterized by a progressive degeneration of the dopaminergic neurons in the substantia <i>nigra pars compacta</i> (SNpc). The marine environment has proven to be a source of unique and diverse chemical structures with great therapeutic potential to be used in the treatment of several pathologies, including neurodegenerative impairments. This review is focused on compounds isolated from marine organisms with neuroprotective activities on in vitro and in vivo models based on their chemical structures, taxonomy, neuroprotective effects, and their possible mechanism of action in PD. About 60 compounds isolated from marine bacteria, fungi, mollusk, sea cucumber, seaweed, soft coral, sponge, and starfish with neuroprotective potential on PD therapy are reported. Peptides, alkaloids, quinones, terpenes, polysaccharides, polyphenols, lipids, pigments, and mycotoxins were isolated from those marine organisms. They can act in several PD hallmarks, reducing oxidative stress, preventing mitochondrial dysfunction, α-synuclein aggregation, and blocking inflammatory pathways through the inhibition translocation of NF-<span style="font-variant: small-caps;">k</span>B factor, reduction of human tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6). This review gathers the marine natural products that have shown pharmacological activities acting on targets belonging to different intracellular signaling pathways related to PD development, which should be considered for future pre-clinical studies. |
| first_indexed | 2024-03-10T23:46:19Z |
| format | Article |
| id | doaj.art-2ed8570108ea4d66b3e72a6d8dc6042f |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T23:46:19Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-2ed8570108ea4d66b3e72a6d8dc6042f2023-11-19T01:58:15ZengMDPI AGMarine Drugs1660-33972023-08-0121845110.3390/md21080451Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease?Joana Silva0Celso Alves1Francisca Soledade2Alice Martins3Susete Pinteus4Helena Gaspar5Amparo Alfonso6Rui Pedrosa7MARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network, ESTM, Polytechnic of Leiria, 2520-614 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network, Polytechnic of Leiria, 2520-630 Peniche, PortugalDepartment of Pharmacology, Faculty of Veterinary, University of Santiago de Compostela, 27002 Lugo, SpainMARE—Marine and Environmental Sciences Centre, ARNET—Aquatic Research Network, ESTM, Polytechnic of Leiria, 2520-614 Peniche, PortugalThe increase in the life expectancy average has led to a growing elderly population, thus leading to a prevalence of neurodegenerative disorders, such as Parkinson’s disease (PD). PD is the second most common neurodegenerative disorder and is characterized by a progressive degeneration of the dopaminergic neurons in the substantia <i>nigra pars compacta</i> (SNpc). The marine environment has proven to be a source of unique and diverse chemical structures with great therapeutic potential to be used in the treatment of several pathologies, including neurodegenerative impairments. This review is focused on compounds isolated from marine organisms with neuroprotective activities on in vitro and in vivo models based on their chemical structures, taxonomy, neuroprotective effects, and their possible mechanism of action in PD. About 60 compounds isolated from marine bacteria, fungi, mollusk, sea cucumber, seaweed, soft coral, sponge, and starfish with neuroprotective potential on PD therapy are reported. Peptides, alkaloids, quinones, terpenes, polysaccharides, polyphenols, lipids, pigments, and mycotoxins were isolated from those marine organisms. They can act in several PD hallmarks, reducing oxidative stress, preventing mitochondrial dysfunction, α-synuclein aggregation, and blocking inflammatory pathways through the inhibition translocation of NF-<span style="font-variant: small-caps;">k</span>B factor, reduction of human tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6). This review gathers the marine natural products that have shown pharmacological activities acting on targets belonging to different intracellular signaling pathways related to PD development, which should be considered for future pre-clinical studies.https://www.mdpi.com/1660-3397/21/8/451neurodegenerative diseaseageing societyneuroinflammationseaweedsneuroprotective activitymarine bioactive compounds |
| spellingShingle | Joana Silva Celso Alves Francisca Soledade Alice Martins Susete Pinteus Helena Gaspar Amparo Alfonso Rui Pedrosa Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease? Marine Drugs neurodegenerative disease ageing society neuroinflammation seaweeds neuroprotective activity marine bioactive compounds |
| title | Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease? |
| title_full | Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease? |
| title_fullStr | Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease? |
| title_full_unstemmed | Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease? |
| title_short | Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson’s Disease? |
| title_sort | marine derived components can they be a potential therapeutic approach to parkinson s disease |
| topic | neurodegenerative disease ageing society neuroinflammation seaweeds neuroprotective activity marine bioactive compounds |
| url | https://www.mdpi.com/1660-3397/21/8/451 |
| work_keys_str_mv | AT joanasilva marinederivedcomponentscantheybeapotentialtherapeuticapproachtoparkinsonsdisease AT celsoalves marinederivedcomponentscantheybeapotentialtherapeuticapproachtoparkinsonsdisease AT franciscasoledade marinederivedcomponentscantheybeapotentialtherapeuticapproachtoparkinsonsdisease AT alicemartins marinederivedcomponentscantheybeapotentialtherapeuticapproachtoparkinsonsdisease AT susetepinteus marinederivedcomponentscantheybeapotentialtherapeuticapproachtoparkinsonsdisease AT helenagaspar marinederivedcomponentscantheybeapotentialtherapeuticapproachtoparkinsonsdisease AT amparoalfonso marinederivedcomponentscantheybeapotentialtherapeuticapproachtoparkinsonsdisease AT ruipedrosa marinederivedcomponentscantheybeapotentialtherapeuticapproachtoparkinsonsdisease |