Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review
Due to excellent mechanical properties and similar elastic modulus compared with human cortical bone, polyetheretherketone (PEEK) has become one of the most promising orthopedic implant materials. However, implant-associated infections (IAIs) remain a challenging issue since PEEK is bio-inert. In or...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.895288/full |
| _version_ | 1818208324568481792 |
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| author | Yihan Wang Yihan Wang Shutao Zhang Shutao Zhang Bin’en Nie Bin’en Nie Xinhua Qu Xinhua Qu Bing Yue Bing Yue |
| author_facet | Yihan Wang Yihan Wang Shutao Zhang Shutao Zhang Bin’en Nie Bin’en Nie Xinhua Qu Xinhua Qu Bing Yue Bing Yue |
| author_sort | Yihan Wang |
| collection | DOAJ |
| description | Due to excellent mechanical properties and similar elastic modulus compared with human cortical bone, polyetheretherketone (PEEK) has become one of the most promising orthopedic implant materials. However, implant-associated infections (IAIs) remain a challenging issue since PEEK is bio-inert. In order to fabricate an antibacterial bio-functional surface, modifications of PEEK had been widely investigated. This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial. We will begin with reviewing different approaches, such as surface-coating modifications and controlled release of antimicrobials. Furthermore, blending modifications and 3D printing technology were discussed. Finally, we compare the effects among different approaches. We aimed to provide an in-depth understanding of the antibacterial modification and optimize the design of the PEEK orthopedic implant. |
| first_indexed | 2024-12-12T04:43:00Z |
| format | Article |
| id | doaj.art-2ed8b62a7dad40a78b0ee128e5073d42 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-12T04:43:00Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-2ed8b62a7dad40a78b0ee128e5073d422022-12-22T00:37:44ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-05-011010.3389/fbioe.2022.895288895288Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A ReviewYihan Wang0Yihan Wang1Shutao Zhang2Shutao Zhang3Bin’en Nie4Bin’en Nie5Xinhua Qu6Xinhua Qu7Bing Yue8Bing Yue9Department of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Bone and Joint Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDepartment of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, ChinaDue to excellent mechanical properties and similar elastic modulus compared with human cortical bone, polyetheretherketone (PEEK) has become one of the most promising orthopedic implant materials. However, implant-associated infections (IAIs) remain a challenging issue since PEEK is bio-inert. In order to fabricate an antibacterial bio-functional surface, modifications of PEEK had been widely investigated. This review summarizes the modification strategies to biofunctionalize PEEK for antibacterial. We will begin with reviewing different approaches, such as surface-coating modifications and controlled release of antimicrobials. Furthermore, blending modifications and 3D printing technology were discussed. Finally, we compare the effects among different approaches. We aimed to provide an in-depth understanding of the antibacterial modification and optimize the design of the PEEK orthopedic implant.https://www.frontiersin.org/articles/10.3389/fbioe.2022.895288/fullPEEKantibacterial propertiesmodification technologypolyetheretherketoneimplant materials |
| spellingShingle | Yihan Wang Yihan Wang Shutao Zhang Shutao Zhang Bin’en Nie Bin’en Nie Xinhua Qu Xinhua Qu Bing Yue Bing Yue Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review Frontiers in Bioengineering and Biotechnology PEEK antibacterial properties modification technology polyetheretherketone implant materials |
| title | Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review |
| title_full | Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review |
| title_fullStr | Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review |
| title_full_unstemmed | Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review |
| title_short | Approaches to Biofunctionalize Polyetheretherketone for Antibacterial: A Review |
| title_sort | approaches to biofunctionalize polyetheretherketone for antibacterial a review |
| topic | PEEK antibacterial properties modification technology polyetheretherketone implant materials |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.895288/full |
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