Gestational trophoblastic neoplasia: A 6 year retrospective study
Aims and Objectives: To study the clinical presentations of gestational trophoblastic neoplasia and its response to chemotherapy. Materials and Methods: This is a retrospective study of 28 women of gestational trophoblastic neoplasia evaluated over a period of 6 years from January 2004 to December 2...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
2014-01-01
|
| Series: | South Asian Journal of Cancer |
| Subjects: | |
| Online Access: | http://journal.sajc.org/article.asp?issn=2278-330X;year=2014;volume=3;issue=1;spage=33;epage=37;aulast=Shrivastava |
| _version_ | 1818416291573137408 |
|---|---|
| author | Sushruta Shrivastava Amal Chandra Kataki Debabrata Barmon Pankaj Deka Chidananda Bhuyan Saikia J Bhargav |
| author_facet | Sushruta Shrivastava Amal Chandra Kataki Debabrata Barmon Pankaj Deka Chidananda Bhuyan Saikia J Bhargav |
| author_sort | Sushruta Shrivastava |
| collection | DOAJ |
| description | Aims and Objectives: To study the clinical presentations of gestational trophoblastic neoplasia and its response to chemotherapy. Materials and Methods: This is a retrospective study of 28 women of gestational trophoblastic neoplasia evaluated over a period of 6 years from January 2004 to December 2009. Patients were evaluated on the basis of their age, number of deliveries, history of abortion or molar pregnancy, and the treatment received. All patients were scored on the basis of WHO scoring system. Patients with low risk (score </=6) received single agent chemotherapy with methotrexate or actinomycin D. Patients with high risk (score >/=7) received multiple agent chemotherapy with EMACO regimen. After completion of chemotherapy patients were followed for a minimum of 2 years. The response to treatment was evaluated during follow-up by clinical examination, beta hCG levels and imaging as and when required. Results: Out of 28 women only 27 could be evaluated, because 1 patient was lost to follow-up. Out of 27 patients, 18 patients (66.67%) achieved complete remission with the first-line chemotherapy and additional 25.92% (7/27) achieved complete remission with second line chemotherapy resulting in complete remission of 92.5% (25/27). Conclusion: Gestational trophoblastic neoplasia is curable if patient is properly evaluated and scored. It shows good response to chemotherapy. |
| first_indexed | 2024-12-14T11:48:33Z |
| format | Article |
| id | doaj.art-2ed97576541f41c9acf0dfd8cee2f751 |
| institution | Directory Open Access Journal |
| issn | 2278-330X 2278-4306 |
| language | English |
| last_indexed | 2024-12-14T11:48:33Z |
| publishDate | 2014-01-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | South Asian Journal of Cancer |
| spelling | doaj.art-2ed97576541f41c9acf0dfd8cee2f7512022-12-21T23:02:27ZengThieme Medical and Scientific Publishers Pvt. Ltd.South Asian Journal of Cancer2278-330X2278-43062014-01-0131333710.4103/2278-330X.126516Gestational trophoblastic neoplasia: A 6 year retrospective studySushruta ShrivastavaAmal Chandra KatakiDebabrata BarmonPankaj DekaChidananda BhuyanSaikia J BhargavAims and Objectives: To study the clinical presentations of gestational trophoblastic neoplasia and its response to chemotherapy. Materials and Methods: This is a retrospective study of 28 women of gestational trophoblastic neoplasia evaluated over a period of 6 years from January 2004 to December 2009. Patients were evaluated on the basis of their age, number of deliveries, history of abortion or molar pregnancy, and the treatment received. All patients were scored on the basis of WHO scoring system. Patients with low risk (score </=6) received single agent chemotherapy with methotrexate or actinomycin D. Patients with high risk (score >/=7) received multiple agent chemotherapy with EMACO regimen. After completion of chemotherapy patients were followed for a minimum of 2 years. The response to treatment was evaluated during follow-up by clinical examination, beta hCG levels and imaging as and when required. Results: Out of 28 women only 27 could be evaluated, because 1 patient was lost to follow-up. Out of 27 patients, 18 patients (66.67%) achieved complete remission with the first-line chemotherapy and additional 25.92% (7/27) achieved complete remission with second line chemotherapy resulting in complete remission of 92.5% (25/27). Conclusion: Gestational trophoblastic neoplasia is curable if patient is properly evaluated and scored. It shows good response to chemotherapy.http://journal.sajc.org/article.asp?issn=2278-330X;year=2014;volume=3;issue=1;spage=33;epage=37;aulast=ShrivastavaActinomycin-DchoriocarcinomachemotherapyEMACO regimengestational trophoblastic neoplasiaMethotrexate |
| spellingShingle | Sushruta Shrivastava Amal Chandra Kataki Debabrata Barmon Pankaj Deka Chidananda Bhuyan Saikia J Bhargav Gestational trophoblastic neoplasia: A 6 year retrospective study South Asian Journal of Cancer Actinomycin-D choriocarcinoma chemotherapy EMACO regimen gestational trophoblastic neoplasia Methotrexate |
| title | Gestational trophoblastic neoplasia: A 6 year retrospective study |
| title_full | Gestational trophoblastic neoplasia: A 6 year retrospective study |
| title_fullStr | Gestational trophoblastic neoplasia: A 6 year retrospective study |
| title_full_unstemmed | Gestational trophoblastic neoplasia: A 6 year retrospective study |
| title_short | Gestational trophoblastic neoplasia: A 6 year retrospective study |
| title_sort | gestational trophoblastic neoplasia a 6 year retrospective study |
| topic | Actinomycin-D choriocarcinoma chemotherapy EMACO regimen gestational trophoblastic neoplasia Methotrexate |
| url | http://journal.sajc.org/article.asp?issn=2278-330X;year=2014;volume=3;issue=1;spage=33;epage=37;aulast=Shrivastava |
| work_keys_str_mv | AT sushrutashrivastava gestationaltrophoblasticneoplasiaa6yearretrospectivestudy AT amalchandrakataki gestationaltrophoblasticneoplasiaa6yearretrospectivestudy AT debabratabarmon gestationaltrophoblasticneoplasiaa6yearretrospectivestudy AT pankajdeka gestationaltrophoblasticneoplasiaa6yearretrospectivestudy AT chidanandabhuyan gestationaltrophoblasticneoplasiaa6yearretrospectivestudy AT saikiajbhargav gestationaltrophoblasticneoplasiaa6yearretrospectivestudy |