Beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosis
Abstract Background Though adherence to disease-modifying therapies (DMTs) among persons with multiple sclerosis (PwMS) varies and is often below 80%, only few prospective studies on adherence examined predictors beyond demographic and clinical characteristics. Objectives Identify antecedents to adh...
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| Format: | Article |
| Language: | English |
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BMC
2021-03-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02149-0 |
| _version_ | 1818855310414053376 |
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| author | Efrat Neter Lea Glass-Marmor Anat Wolkowitz Idit Lavi Ariel Miller |
| author_facet | Efrat Neter Lea Glass-Marmor Anat Wolkowitz Idit Lavi Ariel Miller |
| author_sort | Efrat Neter |
| collection | DOAJ |
| description | Abstract Background Though adherence to disease-modifying therapies (DMTs) among persons with multiple sclerosis (PwMS) varies and is often below 80%, only few prospective studies on adherence examined predictors beyond demographic and clinical characteristics. Objectives Identify antecedents to adherence and persistence to DMT in a prospective design among PwMS. Methods PwMS (n = 186) were prospectively assessed at three time points: baseline, 6 (Time 1) and 12 months later (Time 2). Clinical, demographic information and patient-reported medication beliefs, illness perceptions, medication habits, perceived health and affect were surveyed in-person. Adherence and persistence were assessed by a combination of self-reports and retrospective review of medication claims. Findings PwMS were 69.9% (Time 1) and 71% (Time 2) adherent to their DMTs and 64.5.9% were persistent. Beliefs about Medications were consistently predictive at both time points (baseline to Time 1 and Time 1 to Time 2) of medication adherence and persistence whereas other perceptions were predictive in some analyses; clinical and demographic characteristics were mostly not predictive of adherence nor persistence. The prospective association of beliefs about medication with adherence held also in multivariate analyses (OR = 0.88, 95% CI 0.78–0.99, p = 0.029). Conclusions Adherence and persistence are predicted by medication beliefs of PwMS. As medication beliefs are modifiable, they should be assessed periodically and targeted as a focus of tailored interventions aimed to improve adherence and consequently health outcomes in PwMS. Registration Clinical trials registry # NCT02488343 , date: 06/08/2015. |
| first_indexed | 2024-12-19T08:06:34Z |
| format | Article |
| id | doaj.art-2eda69aa6a7a4215ad2905c3a3b06c43 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-19T08:06:34Z |
| publishDate | 2021-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-2eda69aa6a7a4215ad2905c3a3b06c432022-12-21T20:29:44ZengBMCBMC Neurology1471-23772021-03-012111910.1186/s12883-021-02149-0Beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosisEfrat Neter0Lea Glass-Marmor1Anat Wolkowitz2Idit Lavi3Ariel Miller4Ruppin Academic CenterRappaport Faculty of Medicine, Technion Institute of TechnologyRappaport Faculty of Medicine, Technion Institute of TechnologyDepartment of Community Medicine & Epidemiology, Carmel Medical CenterRappaport Faculty of Medicine, Technion Institute of TechnologyAbstract Background Though adherence to disease-modifying therapies (DMTs) among persons with multiple sclerosis (PwMS) varies and is often below 80%, only few prospective studies on adherence examined predictors beyond demographic and clinical characteristics. Objectives Identify antecedents to adherence and persistence to DMT in a prospective design among PwMS. Methods PwMS (n = 186) were prospectively assessed at three time points: baseline, 6 (Time 1) and 12 months later (Time 2). Clinical, demographic information and patient-reported medication beliefs, illness perceptions, medication habits, perceived health and affect were surveyed in-person. Adherence and persistence were assessed by a combination of self-reports and retrospective review of medication claims. Findings PwMS were 69.9% (Time 1) and 71% (Time 2) adherent to their DMTs and 64.5.9% were persistent. Beliefs about Medications were consistently predictive at both time points (baseline to Time 1 and Time 1 to Time 2) of medication adherence and persistence whereas other perceptions were predictive in some analyses; clinical and demographic characteristics were mostly not predictive of adherence nor persistence. The prospective association of beliefs about medication with adherence held also in multivariate analyses (OR = 0.88, 95% CI 0.78–0.99, p = 0.029). Conclusions Adherence and persistence are predicted by medication beliefs of PwMS. As medication beliefs are modifiable, they should be assessed periodically and targeted as a focus of tailored interventions aimed to improve adherence and consequently health outcomes in PwMS. Registration Clinical trials registry # NCT02488343 , date: 06/08/2015.https://doi.org/10.1186/s12883-021-02149-0Disease modifying therapyMedication adherenceMedication beliefsmultiple sclerosisparticipatory medicinePatient reported outcomes |
| spellingShingle | Efrat Neter Lea Glass-Marmor Anat Wolkowitz Idit Lavi Ariel Miller Beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosis BMC Neurology Disease modifying therapy Medication adherence Medication beliefs multiple sclerosis participatory medicine Patient reported outcomes |
| title | Beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosis |
| title_full | Beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosis |
| title_fullStr | Beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosis |
| title_full_unstemmed | Beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosis |
| title_short | Beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosis |
| title_sort | beliefs about medication as predictors of medication adherence in a prospective cohort study among persons with multiple sclerosis |
| topic | Disease modifying therapy Medication adherence Medication beliefs multiple sclerosis participatory medicine Patient reported outcomes |
| url | https://doi.org/10.1186/s12883-021-02149-0 |
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