Disruption of the <i>cpsE</i> and <i>endA</i> Genes Attenuates <i>Streptococcus pneumoniae</i> Virulence: Towards the Development of a Live Attenuated Vaccine Candidate

Disruption of the <i>cpsE</i> and <i>endA</i> Genes Attenuates <i>Streptococcus pneumoniae</i> Virulence: Towards the Development of a Live Attenuated Vaccine Candidate

The majority of deaths due to <i>Streptococcus pneumoniae</i> infections are in developing countries. Although polysaccharide-based pneumococcal vaccines are available, newer types of vaccines are needed to increase vaccine affordability, particularly in developing countries, and to prov...

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Bibliographic Details
Main Authors: Malik Amonov, Nordin Simbak, Wan Mohd. Razin Wan Hassan, Salwani Ismail, Nor Iza A. Rahman, Stuart C. Clarke, Chew Chieng Yeo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Vaccines
Subjects:
<i>Streptococcus pneumoniae</i>
vaccine
live attenuated vaccine
capsule biosynthesis gene
<i>cpsE</i>
endonuclease A
Online Access:https://www.mdpi.com/2076-393X/8/2/187

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