Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study
Mammalian locomotion is generated by central pattern generators (CPGs) in the spinal cord, which produce alternating flexor and extensor activities controlling the locomotor movements of each limb. Afferent feedback signals from the limbs are integrated by the CPGs to provide adaptive control of loc...
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| Format: | Article |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.825149/full |
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| author | Yongi Kim Shinya Aoi Soichiro Fujiki Simon M. Danner Sergey N. Markin Jessica Ausborn Ilya A. Rybak Dai Yanagihara Kei Senda Kazuo Tsuchiya |
| author_facet | Yongi Kim Shinya Aoi Soichiro Fujiki Simon M. Danner Sergey N. Markin Jessica Ausborn Ilya A. Rybak Dai Yanagihara Kei Senda Kazuo Tsuchiya |
| author_sort | Yongi Kim |
| collection | DOAJ |
| description | Mammalian locomotion is generated by central pattern generators (CPGs) in the spinal cord, which produce alternating flexor and extensor activities controlling the locomotor movements of each limb. Afferent feedback signals from the limbs are integrated by the CPGs to provide adaptive control of locomotion. Responses of CPG-generated neural activity to afferent feedback stimulation have been previously studied during fictive locomotion in immobilized cats. Yet, locomotion in awake, behaving animals involves dynamic interactions between central neuronal circuits, afferent feedback, musculoskeletal system, and environment. To study these complex interactions, we developed a model simulating interactions between a half-center CPG and the musculoskeletal system of a cat hindlimb. Then, we analyzed the role of afferent feedback in the locomotor adaptation from a dynamic viewpoint using the methods of dynamical systems theory and nullcline analysis. Our model reproduced limb movements during regular cat walking as well as adaptive changes of these movements when the foot steps into a hole. The model generates important insights into the mechanism for adaptive locomotion resulting from dynamic interactions between the CPG-based neural circuits, the musculoskeletal system, and the environment. |
| first_indexed | 2024-12-13T22:38:37Z |
| format | Article |
| id | doaj.art-2edbff31f39544258a077b846c691a94 |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-12-13T22:38:37Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-2edbff31f39544258a077b846c691a942022-12-21T23:28:55ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-04-011010.3389/fbioe.2022.825149825149Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling StudyYongi Kim0Shinya Aoi1Soichiro Fujiki2Simon M. Danner3Sergey N. Markin4Jessica Ausborn5Ilya A. Rybak6Dai Yanagihara7Kei Senda8Kazuo Tsuchiya9Department of Aeronautics and Astronautics, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Kyoto, JapanDepartment of Aeronautics and Astronautics, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Kyoto, JapanDepartment of Physiology, School of Medicine, Dokkyo Medical University, Tochigi, JapanDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesDepartment of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA, United StatesDepartment of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, JapanDepartment of Aeronautics and Astronautics, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Kyoto, JapanDepartment of Aeronautics and Astronautics, Graduate School of Engineering, Kyoto University, Kyoto Daigaku-Katsura, Kyoto, JapanMammalian locomotion is generated by central pattern generators (CPGs) in the spinal cord, which produce alternating flexor and extensor activities controlling the locomotor movements of each limb. Afferent feedback signals from the limbs are integrated by the CPGs to provide adaptive control of locomotion. Responses of CPG-generated neural activity to afferent feedback stimulation have been previously studied during fictive locomotion in immobilized cats. Yet, locomotion in awake, behaving animals involves dynamic interactions between central neuronal circuits, afferent feedback, musculoskeletal system, and environment. To study these complex interactions, we developed a model simulating interactions between a half-center CPG and the musculoskeletal system of a cat hindlimb. Then, we analyzed the role of afferent feedback in the locomotor adaptation from a dynamic viewpoint using the methods of dynamical systems theory and nullcline analysis. Our model reproduced limb movements during regular cat walking as well as adaptive changes of these movements when the foot steps into a hole. The model generates important insights into the mechanism for adaptive locomotion resulting from dynamic interactions between the CPG-based neural circuits, the musculoskeletal system, and the environment.https://www.frontiersin.org/articles/10.3389/fbioe.2022.825149/fullwalkingcatneuromusculoskeletal modelcentral pattern generatorafferent feedback |
| spellingShingle | Yongi Kim Shinya Aoi Soichiro Fujiki Simon M. Danner Sergey N. Markin Jessica Ausborn Ilya A. Rybak Dai Yanagihara Kei Senda Kazuo Tsuchiya Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study Frontiers in Bioengineering and Biotechnology walking cat neuromusculoskeletal model central pattern generator afferent feedback |
| title | Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study |
| title_full | Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study |
| title_fullStr | Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study |
| title_full_unstemmed | Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study |
| title_short | Contribution of Afferent Feedback to Adaptive Hindlimb Walking in Cats: A Neuromusculoskeletal Modeling Study |
| title_sort | contribution of afferent feedback to adaptive hindlimb walking in cats a neuromusculoskeletal modeling study |
| topic | walking cat neuromusculoskeletal model central pattern generator afferent feedback |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.825149/full |
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