Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland Inflammation in a Mouse Model of Sjögren's Syndrome

Ly9 (CD229) Antibody Targeting Depletes Marginal Zone and Germinal Center B Cells in Lymphoid Tissues and Reduces Salivary Gland Inflammation in a Mouse Model of Sjögren's Syndrome

Sjögren's Syndrome (SjS) is a common chronic autoimmune disease characterized by the B cell hyperactivation, lymphocyte infiltration, and tissue damage of exocrine glands. It can also present life-threatening extraglandular manifestations, such as pulmonary and hepatic involvement, renal inflam...

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Bibliographic Details
Main Authors: Joan Puñet-Ortiz, Manuel Sáez Moya, Marta Cuenca, Eduardo Caleiras, Adriana Lazaro, Pablo Engel
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
Sjögren's Syndrome
antibody targeting
SLAM family receptors
Ly9
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02661/full

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