Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia
Canine distemper virus (CDV) is considered a reemerging disease-causing agent in domestic dogs because it presents high divergence among circulating strains worldwide. In Colombia, the South America-3 and South America/North America-4 lineages co-circulate in domestic dogs, both in the Medellin metr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-12-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/9/1/26 |
| _version_ | 1811264061227139072 |
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| author | July Duque-Valencia Francisco J. Diaz Julian Ruiz-Saenz |
| author_facet | July Duque-Valencia Francisco J. Diaz Julian Ruiz-Saenz |
| author_sort | July Duque-Valencia |
| collection | DOAJ |
| description | Canine distemper virus (CDV) is considered a reemerging disease-causing agent in domestic dogs because it presents high divergence among circulating strains worldwide. In Colombia, the South America-3 and South America/North America-4 lineages co-circulate in domestic dogs, both in the Medellin metropolitan area. In this paper, two full CDV genomes from each viral lineage circulating in Medellin were sequenced; we explored the phylogenetic relationship with the available genome sequences; we described the presence of CDV mutations in the South America-3 and South America/North America-4 lineages associated with adaptation to human cells and a crossing of the species barrier and pathogenicity; and we established the evolutionary rates and time of the closest common ancestor for each gene and characterized the presentation of multiple genomic sites by positive selection. |
| first_indexed | 2024-04-12T19:56:21Z |
| format | Article |
| id | doaj.art-2edd2846058e4da69210fdf9732d32b6 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-12T19:56:21Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-2edd2846058e4da69210fdf9732d32b62022-12-22T03:18:39ZengMDPI AGPathogens2076-08172019-12-01912610.3390/pathogens9010026pathogens9010026Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in ColombiaJuly Duque-Valencia0Francisco J. Diaz1Julian Ruiz-Saenz2Grupo de Investigación en Ciencias Animales—GRICA, Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia, sede Bucaramanga, Calle 30A # 33-51, 680002 Bucaramanga, ColombiaGrupo Inmunovirología, Facultad de Medicina, Universidad de Antioquia, Calle 70 No. 52-21, 050010 Medellín, ColombiaGrupo de Investigación en Ciencias Animales—GRICA, Facultad de Medicina Veterinaria y Zootecnia, Universidad Cooperativa de Colombia, sede Bucaramanga, Calle 30A # 33-51, 680002 Bucaramanga, ColombiaCanine distemper virus (CDV) is considered a reemerging disease-causing agent in domestic dogs because it presents high divergence among circulating strains worldwide. In Colombia, the South America-3 and South America/North America-4 lineages co-circulate in domestic dogs, both in the Medellin metropolitan area. In this paper, two full CDV genomes from each viral lineage circulating in Medellin were sequenced; we explored the phylogenetic relationship with the available genome sequences; we described the presence of CDV mutations in the South America-3 and South America/North America-4 lineages associated with adaptation to human cells and a crossing of the species barrier and pathogenicity; and we established the evolutionary rates and time of the closest common ancestor for each gene and characterized the presentation of multiple genomic sites by positive selection.https://www.mdpi.com/2076-0817/9/1/26phylogenomicsreemerginglineages co-circulationgenome cdv |
| spellingShingle | July Duque-Valencia Francisco J. Diaz Julian Ruiz-Saenz Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia Pathogens phylogenomics reemerging lineages co-circulation genome cdv |
| title | Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia |
| title_full | Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia |
| title_fullStr | Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia |
| title_full_unstemmed | Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia |
| title_short | Phylogenomic Analysis of Two Co-Circulating Canine Distemper Virus Lineages in Colombia |
| title_sort | phylogenomic analysis of two co circulating canine distemper virus lineages in colombia |
| topic | phylogenomics reemerging lineages co-circulation genome cdv |
| url | https://www.mdpi.com/2076-0817/9/1/26 |
| work_keys_str_mv | AT julyduquevalencia phylogenomicanalysisoftwococirculatingcaninedistemperviruslineagesincolombia AT franciscojdiaz phylogenomicanalysisoftwococirculatingcaninedistemperviruslineagesincolombia AT julianruizsaenz phylogenomicanalysisoftwococirculatingcaninedistemperviruslineagesincolombia |