Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and Starvation
Through the promotion of phagolysosome formation, autophagy has emerged as a crucial mechanism to eradicate intracellular <i>Mycobacterium tuberculosis</i> (Mtb). A cell-autonomous host defense mechanism called lysosome biogenesis and autophagy transports cytoplasmic cargos and bacterial...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/12/2944 |
| _version_ | 1827574068998569984 |
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| author | Richa Dwivedi Piyush Baindara |
| author_facet | Richa Dwivedi Piyush Baindara |
| author_sort | Richa Dwivedi |
| collection | DOAJ |
| description | Through the promotion of phagolysosome formation, autophagy has emerged as a crucial mechanism to eradicate intracellular <i>Mycobacterium tuberculosis</i> (Mtb). A cell-autonomous host defense mechanism called lysosome biogenesis and autophagy transports cytoplasmic cargos and bacterial phagosomes to lysosomes for destruction during infection. Similar occurrences occurred in stressful or starvation circumstances and led to autophagy, which is harmful to the cell. It is interesting to note that under both hunger and infection states, the transcription factor EB (TFEB) acts as a master regulator of lysosomal activities and autophagy. This review highlighted recent research on the multitier regulation of TFEB-induced autophagy by a variety of host effectors and Mtb sulfolipid during Mtb infection and starvation. In general, the research presented here sheds light on how lysosome biogenesis and autophagy are differentially regulated by the TFEB during Mtb infection and starvation. |
| first_indexed | 2024-03-08T20:30:42Z |
| format | Article |
| id | doaj.art-2ede15ad5c14475091e1e48dcb4bded5 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-08T20:30:42Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-2ede15ad5c14475091e1e48dcb4bded52023-12-22T14:26:10ZengMDPI AGMicroorganisms2076-26072023-12-011112294410.3390/microorganisms11122944Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and StarvationRicha Dwivedi0Piyush Baindara1Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15260, USARadiation Oncology, NextGen Precision Health, School of Medicine, University of Missouri, Columbia, MO 65211, USAThrough the promotion of phagolysosome formation, autophagy has emerged as a crucial mechanism to eradicate intracellular <i>Mycobacterium tuberculosis</i> (Mtb). A cell-autonomous host defense mechanism called lysosome biogenesis and autophagy transports cytoplasmic cargos and bacterial phagosomes to lysosomes for destruction during infection. Similar occurrences occurred in stressful or starvation circumstances and led to autophagy, which is harmful to the cell. It is interesting to note that under both hunger and infection states, the transcription factor EB (TFEB) acts as a master regulator of lysosomal activities and autophagy. This review highlighted recent research on the multitier regulation of TFEB-induced autophagy by a variety of host effectors and Mtb sulfolipid during Mtb infection and starvation. In general, the research presented here sheds light on how lysosome biogenesis and autophagy are differentially regulated by the TFEB during Mtb infection and starvation.https://www.mdpi.com/2076-2607/11/12/2944autophagy<i>Mycobacterium tuberculosis</i>TFEBinfectionstarvationhost-directed therapies |
| spellingShingle | Richa Dwivedi Piyush Baindara Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and Starvation Microorganisms autophagy <i>Mycobacterium tuberculosis</i> TFEB infection starvation host-directed therapies |
| title | Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and Starvation |
| title_full | Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and Starvation |
| title_fullStr | Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and Starvation |
| title_full_unstemmed | Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and Starvation |
| title_short | Differential Regulation of TFEB-Induced Autophagy during Mtb Infection and Starvation |
| title_sort | differential regulation of tfeb induced autophagy during mtb infection and starvation |
| topic | autophagy <i>Mycobacterium tuberculosis</i> TFEB infection starvation host-directed therapies |
| url | https://www.mdpi.com/2076-2607/11/12/2944 |
| work_keys_str_mv | AT richadwivedi differentialregulationoftfebinducedautophagyduringmtbinfectionandstarvation AT piyushbaindara differentialregulationoftfebinducedautophagyduringmtbinfectionandstarvation |