Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana.
An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana. In an attempt to pinpoint alterations in the signaling pathways responsible for the NK-cell dysfuncti...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2016-03-01
|
| Series: | PLoS Neglected Tropical Diseases |
| Online Access: | http://europepmc.org/articles/PMC4816531?pdf=render |
| _version_ | 1829509250594897920 |
|---|---|
| author | Edith A Fernández-Figueroa Iván Imaz-Rosshandler Juan E Castillo-Fernández Haydee Miranda-Ortíz Juan C Fernández-López Ingeborg Becker Claudia Rangel-Escareño |
| author_facet | Edith A Fernández-Figueroa Iván Imaz-Rosshandler Juan E Castillo-Fernández Haydee Miranda-Ortíz Juan C Fernández-López Ingeborg Becker Claudia Rangel-Escareño |
| author_sort | Edith A Fernández-Figueroa |
| collection | DOAJ |
| description | An important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana. In an attempt to pinpoint alterations in the signaling pathways responsible for the NK-cell dysfunction in patients with DCL, this study aimed at identifying differences in the NK-cell response towards Leishmania mexicana lipophosphoglycan (LPG) between patients with localized and diffuse cutaneous leishmaniasis through gene expression profiling. Our results indicate that important genes involved in the innate immune response to Leishmania are down-regulated in NK cells from DCL patients, particularly TLR and JAK/STAT signaling pathways. This down-regulation showed to be independent of LPG stimulation. The study sheds new light for understanding the mechanisms that undermine the correct effector functions of NK cells in patients with diffuse cutaneous leishmaniasis contributing to a better understanding of the pathobiology of leishmaniasis. |
| first_indexed | 2024-12-16T11:42:01Z |
| format | Article |
| id | doaj.art-2edf093174524b4aa7963486a47de8ea |
| institution | Directory Open Access Journal |
| issn | 1935-2727 1935-2735 |
| language | English |
| last_indexed | 2024-12-16T11:42:01Z |
| publishDate | 2016-03-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Neglected Tropical Diseases |
| spelling | doaj.art-2edf093174524b4aa7963486a47de8ea2022-12-21T22:32:55ZengPublic Library of Science (PLoS)PLoS Neglected Tropical Diseases1935-27271935-27352016-03-01103e000457010.1371/journal.pntd.0004570Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana.Edith A Fernández-FigueroaIván Imaz-RosshandlerJuan E Castillo-FernándezHaydee Miranda-OrtízJuan C Fernández-LópezIngeborg BeckerClaudia Rangel-EscareñoAn important NK-cell inhibition with reduced TNF-α, IFN-γ and TLR2 expression had previously been identified in patients with diffuse cutaneous leishmaniasis (DCL) infected with Leishmania mexicana. In an attempt to pinpoint alterations in the signaling pathways responsible for the NK-cell dysfunction in patients with DCL, this study aimed at identifying differences in the NK-cell response towards Leishmania mexicana lipophosphoglycan (LPG) between patients with localized and diffuse cutaneous leishmaniasis through gene expression profiling. Our results indicate that important genes involved in the innate immune response to Leishmania are down-regulated in NK cells from DCL patients, particularly TLR and JAK/STAT signaling pathways. This down-regulation showed to be independent of LPG stimulation. The study sheds new light for understanding the mechanisms that undermine the correct effector functions of NK cells in patients with diffuse cutaneous leishmaniasis contributing to a better understanding of the pathobiology of leishmaniasis.http://europepmc.org/articles/PMC4816531?pdf=render |
| spellingShingle | Edith A Fernández-Figueroa Iván Imaz-Rosshandler Juan E Castillo-Fernández Haydee Miranda-Ortíz Juan C Fernández-López Ingeborg Becker Claudia Rangel-Escareño Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana. PLoS Neglected Tropical Diseases |
| title | Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana. |
| title_full | Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana. |
| title_fullStr | Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana. |
| title_full_unstemmed | Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana. |
| title_short | Down-Regulation of TLR and JAK/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana. |
| title_sort | down regulation of tlr and jak stat pathway genes is associated with diffuse cutaneous leishmaniasis a gene expression analysis in nk cells from patients infected with leishmania mexicana |
| url | http://europepmc.org/articles/PMC4816531?pdf=render |
| work_keys_str_mv | AT edithafernandezfigueroa downregulationoftlrandjakstatpathwaygenesisassociatedwithdiffusecutaneousleishmaniasisageneexpressionanalysisinnkcellsfrompatientsinfectedwithleishmaniamexicana AT ivanimazrosshandler downregulationoftlrandjakstatpathwaygenesisassociatedwithdiffusecutaneousleishmaniasisageneexpressionanalysisinnkcellsfrompatientsinfectedwithleishmaniamexicana AT juanecastillofernandez downregulationoftlrandjakstatpathwaygenesisassociatedwithdiffusecutaneousleishmaniasisageneexpressionanalysisinnkcellsfrompatientsinfectedwithleishmaniamexicana AT haydeemirandaortiz downregulationoftlrandjakstatpathwaygenesisassociatedwithdiffusecutaneousleishmaniasisageneexpressionanalysisinnkcellsfrompatientsinfectedwithleishmaniamexicana AT juancfernandezlopez downregulationoftlrandjakstatpathwaygenesisassociatedwithdiffusecutaneousleishmaniasisageneexpressionanalysisinnkcellsfrompatientsinfectedwithleishmaniamexicana AT ingeborgbecker downregulationoftlrandjakstatpathwaygenesisassociatedwithdiffusecutaneousleishmaniasisageneexpressionanalysisinnkcellsfrompatientsinfectedwithleishmaniamexicana AT claudiarangelescareno downregulationoftlrandjakstatpathwaygenesisassociatedwithdiffusecutaneousleishmaniasisageneexpressionanalysisinnkcellsfrompatientsinfectedwithleishmaniamexicana |