Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activity
In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic activity both in vitro and in vivo. The in vitro...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2015-01-01
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| Series: | Bangladesh Journal of Pharmacology |
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| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/20748 |
| _version_ | 1811322211801235456 |
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| author | Satyajit Dutta G. Raghava Ravali Supratim Ray K. Nagarajan |
| author_facet | Satyajit Dutta G. Raghava Ravali Supratim Ray K. Nagarajan |
| author_sort | Satyajit Dutta |
| collection | DOAJ |
| description | In the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic activity both in vitro and in vivo. The in vitro activity was performed against five human cell lines like human breast cancer (MCF-7), leukemia (K-562), ovarian cancer (OVACAR-3), human colon adenocarcinoma (HT-29) and Human kidney carcinoma (A-498). The in vivo activity was performed in female swiss albino mice against Ehrlich ascites carcinoma (EAC). Among the synthesized compounds, ureide, p-bromoanilide, p-nitoanilide, o-bromoanilide and p-methylanilide derivatives of 2-(4-methyl benzene sulphonyl)-pentanedioic acid amides showed encouraging activity in both the in vitro and in vivo compared to other compounds. It was noticed that final derivative compounds show a better activity than the parent compound and it may be due to the substituents present in those compounds. |
| first_indexed | 2024-04-13T13:31:14Z |
| format | Article |
| id | doaj.art-2edf13768d454fe08f8d0afcb8e2f147 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-04-13T13:31:14Z |
| publishDate | 2015-01-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-2edf13768d454fe08f8d0afcb8e2f1472022-12-22T02:44:58ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882015-01-01101Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activitySatyajit Dutta0G. Raghava Ravali1Supratim Ray2K. Nagarajan3Department of Pharmaceutical Chemistry, IIMT College of Medical Sciences, Meerut 250001, Uttar PradeshDepartment of Pharmaceutical Chemistry, Dr. B. C. Roy College of Pharmacy & Allied Health Sciences, Durgapur 713206, West BengalDepartment of Pharmaceutical Sciences, Assam University, Silchar 788011, AssamDepartment of Pharmaceutical Chemistry, KIET School of Pharmacy, Muradnagar, Ghaziabad 201206, Uttar PradeshIn the present work few novel 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives and the basic compound 2-(4-methylphenylsulfonamido)pentanedioic acid have been synthesized, characterized and screened for their possible antineoplastic activity both in vitro and in vivo. The in vitro activity was performed against five human cell lines like human breast cancer (MCF-7), leukemia (K-562), ovarian cancer (OVACAR-3), human colon adenocarcinoma (HT-29) and Human kidney carcinoma (A-498). The in vivo activity was performed in female swiss albino mice against Ehrlich ascites carcinoma (EAC). Among the synthesized compounds, ureide, p-bromoanilide, p-nitoanilide, o-bromoanilide and p-methylanilide derivatives of 2-(4-methyl benzene sulphonyl)-pentanedioic acid amides showed encouraging activity in both the in vitro and in vivo compared to other compounds. It was noticed that final derivative compounds show a better activity than the parent compound and it may be due to the substituents present in those compounds.https://www.banglajol.info/index.php/BJP/article/view/20748Glutamic acid (2-amino pentanedioic acid)AnticancerMTT assayEhrlich ascites carcinoma. |
| spellingShingle | Satyajit Dutta G. Raghava Ravali Supratim Ray K. Nagarajan Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activity Bangladesh Journal of Pharmacology Glutamic acid (2-amino pentanedioic acid) Anticancer MTT assay Ehrlich ascites carcinoma. |
| title | Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activity |
| title_full | Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activity |
| title_fullStr | Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activity |
| title_full_unstemmed | Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activity |
| title_short | Synthesis, structural characterization and biological activity of 2-(4-methylbenzenesulphonamido)pentanedioic acid amide derivatives: <i>In vitro</i> and <i>in vivo</i> antineoplastic activity |
| title_sort | synthesis structural characterization and biological activity of 2 4 methylbenzenesulphonamido pentanedioic acid amide derivatives i in vitro i and i in vivo i antineoplastic activity |
| topic | Glutamic acid (2-amino pentanedioic acid) Anticancer MTT assay Ehrlich ascites carcinoma. |
| url | https://www.banglajol.info/index.php/BJP/article/view/20748 |
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