Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction

Fibrosis: a structural modulator of Sinoatrial Node physiology and dysfunction

Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure characterized by clusters of specialized cardiomyocytes, enmeshed within strands of connective tissue or fibrosis. Intranodal fibrosis i...

Full description

Bibliographic Details
Main Authors:	Thomas A Csepe, Anuradha eKalyanasundaram, Brian J Hansen, Jichao eZhao, Vadim V Fedorov
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2015-02-01
Series:	Frontiers in Physiology
Subjects:	Aging Atrial Fibrillation Fibrosis Heart Failure Sinoatrial Node sinus node dysfunction
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00037/full

Similar Items

Genetic Complexity of Sinoatrial Node Dysfunction
by: Michael J. Wallace, et al.
Published: (2021-04-01)

Distinct Effects of Ibrutinib and Acalabrutinib on Mouse Atrial and Sinoatrial Node Electrophysiology and Arrhythmogenesis
by: Jari M. Tuomi, et al.
Published: (2021-11-01)

Genetics of sinoatrial node function and heart rate disorders
by: Lieve E. van der Maarel, et al.
Published: (2023-05-01)

Three-dimensional electroanatomic mapping characteristics of superior vena cava myocardial sleeve and sinoatrial node in patients with atrial fibrillation
by: Xinguang Chen, et al.
Published: (2022-09-01)

Two‐Pore K+ Channel TREK‐1 Regulates Sinoatrial Node Membrane Excitability
by: Sathya D. Unudurthi, et al.
Published: (2016-04-01)

Atrial and Sinoatrial Node Development in the Zebrafish Heart
by: Kendall E. Martin, et al.
Published: (2021-02-01)

Assembly of the Cardiac Pacemaking Complex: Electrogenic Principles of Sinoatrial Node Morphogenesis
by: Marietta Easterling, et al.
Published: (2021-04-01)

Synchronization of Pacemaking in the Sinoatrial Node: A Mathematical Modeling Study
by: Daniel Gratz, et al.
Published: (2018-06-01)

Cellular and Molecular Mechanisms of Functional Hierarchy of Pacemaker Clusters in the Sinoatrial Node: New Insights into Sick Sinus Syndrome
by: Di Lang, et al.
Published: (2021-04-01)

Controlling parasympathetic regulation of heart rate: a gatekeeperrole for RGS proteins in the sinoatrial node
by: Alexandra eMighiu, et al.
Published: (2012-06-01)

Meaningful local signalling in sinoatrial node identified by random matrix theory and PCA
by: Chloe F Norris, et al.
Published: (2023-01-01)

Synergy between Membrane Currents Prevents Severe Bradycardia in Mouse Sinoatrial Node Tissue
by: Limor Arbel Ganon, et al.
Published: (2023-03-01)

Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker
by: Rashid Minhas, et al.
Published: (2021-10-01)

Inflammatory degranulation of the cardiac resident mast cells suppresses the pacemaking and affects activation pattern in the sinoatrial node
by: Vlad S. Kuzmin, et al.
Published: (2022-03-01)

Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation
by: Chaohui Zhang, et al.
Published: (2021-06-01)

Structural and Electrical Remodeling of the Sinoatrial Node in Diabetes: New Dimensions and Perspectives
by: Lina T. Al Kury, et al.
Published: (2022-07-01)

Novel Insights into the Sinoatrial Node in Single-Cell RNA Sequencing: From Developmental Biology to Physiological Function
by: Wei Fan, et al.
Published: (2022-11-01)

Tbx5 overexpression in embryoid bodies increases TAK1 expression but does not enhance the differentiation of sinoatrial node cardiomyocytes
by: Yunkai Dai, et al.
Published: (2023-06-01)

Origem das artérias dos nós sinoatrial e atrioventricular em população do sul da Índia: um estudo angiográfico Origen de las arterias de los nódulos sinusal y atrioventricular en población del Sur de la India: un estudio angiográfico Origin of the sinoatrial and atrioventricular nodal arteries in South Indians: an angiographic study
by: Lakshmi Ramanathan, et al.
Published: (2009-05-01)

Importância da anatomia da circulação coronária atrial na operação de Cox para controle da fibrilação atrial The importance of atrial coronary circulation on Cox surgery for control atrial fibrillation
by: Marcelo B. JATENE, et al.
Published: (1999-01-01)

Characterization of diverse populations of sinoatrial node cells and their proliferation potential at single nucleus resolutionResearch in context
by: Jia-Hua Qu, et al.
Published: (2023-01-01)

PDGFRα-Signaling Is Dispensable for the Development of the Sinoatrial Node After Its Fate Commitment
by: Xi Zheng, et al.
Published: (2021-06-01)

SHOX2 refines the identification of human sinoatrial nodal cell population in the in vitro cardiac differentiation
by: Takayuki Wakimizu, et al.
Published: (2022-12-01)

Atrial Tachyarrhythmias and Atrial Flutter: the Basics of Diagnostics and Modern Opportunities of Therapy
by: Yu. A. Bunin, et al.
Published: (2019-03-01)

The mechano-electric feedback mediates the dual effect of stretch in mouse sinoatrial tissue
by: Limor Arbel Ganon, et al.
Published: (2023-09-01)

Effects of acetylcholine and noradrenalin on action potentials of isolated rabbit sinoatrial and atrial myocytes
by: Arie O. Verkerk, et al.
Published: (2012-05-01)

The Effect of Astragaloside on Pacemaker Current and the Cytoskeleton in Rabbit Sinoatrial Node Cells Under the Ischemia and Reperfusion Condition
by: Ruxiu Liu, et al.
Published: (2018-05-01)

Histopathological changes in the electrical conduction of cardiac nodes after acute myocardial infarction in dogs and horses, compared with findings in humans: A histological, morphometrical, and immunohistochemical study
by: Fabián Gómez-Torres, et al.
Published: (2023-10-01)

Spontaneous electrical activity of guinea-pig sinoatrial cells under modulation of two different pacemaker mechanisms
by: Francesca Cacciani, et al.
Published: (2014-01-01)

Extracardiac Vagal Stimulation-Assisted Cardioneuroablation: Dynamically Evaluating the Impact of Sequential Ganglionated Plexus Ablation on Vagal Control of SAN and AVN in Patients with Sinoatrial Node Dysfunction
by: Weijie Chen, et al.
Published: (2022-06-01)

In-vivo Sino-Atrial Node Mapping in Children and Adults With Congenital Heart Disease
by: Rohit K. Kharbanda, et al.
Published: (2022-07-01)

A new and simple technique for vagal ganglia ablation in a patient with functional atrioventricular block: Electroanatomical approach
by: Tolga Aksu, et al.
Published: (2018-09-01)

Transcriptional and Epigenetic Landscape of Cardiac Pacemaker Cells: Insights Into Cellular Specialization in the Sinoatrial Node
by: Ravi Mandla, et al.
Published: (2021-07-01)

Ca2+ cycling properties are conserved despite bradycardic effects of heart failure in sinoatrial node cells
by: Arie O. Verkerk, et al.
Published: (2015-02-01)

Mechanistic Insights Into the Reduced Pacemaking Rate of the Rabbit Sinoatrial Node During Postnatal Development: A Simulation Study
by: Azzah M. Alghamdi, et al.
Published: (2020-11-01)

Clinical Significance of the Head-Up Tilt Test in Improving Prognosis in Patients with Possible Neurally Mediated Syncope
by: Kengo Ayabe, et al.
Published: (2021-09-01)

Pathophysiology of Cav1.3 L-type calcium channels in the heart
by: Sahil Zaveri, et al.
Published: (2023-03-01)

Pacing mode survival in patients with single chamber atrial pacemaker for sinus node dysfunction
by: Ramanathan Velayuthan, et al.
Published: (2024-01-01)

Chemically defined and small molecules-based generation of sinoatrial node-like cells
by: Xiaojie Hou, et al.
Published: (2022-04-01)

The Functional Role of Hyperpolarization Activated Current (If) on Cardiac Pacemaking in Human vs. in the Rabbit Sinoatrial Node: A Simulation and Theoretical Study
by: Xiangyun Bai, et al.
Published: (2021-08-01)