A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements
Herbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectivenes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/15/11/1371 |
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| author | Arshiya Sultana Md Belal Bin Heyat Khaleequr Rahman Radhika Kunnavil Mohamed Joonus Aynul Fazmiya Faijan Akhtar Sumbul Juan Luis Vidal Mazón Carmen Lili Rodríguez Isabel De La Torre Díez |
| author_facet | Arshiya Sultana Md Belal Bin Heyat Khaleequr Rahman Radhika Kunnavil Mohamed Joonus Aynul Fazmiya Faijan Akhtar Sumbul Juan Luis Vidal Mazón Carmen Lili Rodríguez Isabel De La Torre Díez |
| author_sort | Arshiya Sultana |
| collection | DOAJ |
| description | Herbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectiveness in alleviating premenstrual symptoms. The published randomized controlled trials (RCTs) were extracted from Google scholar, PubMed, Scopus and PROSPERO databases. The risk of bias in randomized trials was assessed by Cochrane risk-of-bias tool. The main outcome parameters were analysed separately based on the Premenstrual Symptom Screening Tool and PMTS and DRSP scores. Secondary parameters of somatic, psychological, and behavioural subscale symptoms of PSST were also analysed. Data synthesis was performed assuming a random-effects model, and standardized mean difference (SMDs) was analysed using SPSS version 28.0.0 (IBM, Armonk, NY, USA). A total of 754 articles were screened, and 15 RCTs were included (<i>n</i> = 1211 patients). Primary results for participants randomized to an intervention reported reduced PSST (<i>n</i> = 9), PMTS (<i>n</i> = 2), and DSR (<i>n</i> = 4) scores with (SMD = −1.44; 95% CI: −1.72 to −1.17), (SMD = −1.69; 95% CI: −3.80 to 0.42) and (SMD = 2.86; 95% CI: 1.02 to 4.69) verses comparator with substantial heterogeneity. Physical (SMD = −1.61; 95% CI = −2.56 to −0.66), behavioural (SMD = −0.60; 95% CI = −1.55 to 0.35) and mood (SMD = 0.57; 95% CI = −0.96 to 2.11) subscale symptom groupings of PSST displayed similar findings. Fifty-three studies (<i>n</i> = 8) were considered at low risk of bias with high quality. Mild adverse events were reported by four RCTs. Based on the existing evidence, herbal medicine and nutritional supplements may be effective and safe for PMS. |
| first_indexed | 2024-03-09T18:44:47Z |
| format | Article |
| id | doaj.art-2ee116f5c3ec4f1c86220f51057f22e1 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T18:44:47Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-2ee116f5c3ec4f1c86220f51057f22e12023-11-24T06:18:52ZengMDPI AGPharmaceuticals1424-82472022-11-011511137110.3390/ph15111371A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional SupplementsArshiya Sultana0Md Belal Bin Heyat1Khaleequr Rahman2Radhika Kunnavil3Mohamed Joonus Aynul Fazmiya4Faijan Akhtar5Sumbul6Juan Luis Vidal Mazón7Carmen Lili Rodríguez8Isabel De La Torre Díez9Department of Ilmul Qabalat wa Amraze Niswan, National Institute of Unani Medicine, Ministry of AYUSH, Bengaluru 560091, Karnataka, IndiaIoT Research Center, College of Computer Science and Software Engineering, Shenzhen University, Shenzhen 518060, ChinaDepartment of Ilmul Saidla, National Institute of Unani Medicine, Ministry of AYUSH, Bengaluru 560091, Karnataka, IndiaDepartment of Biostatistics, National Institute of Unani Medicine, Ministry of AYUSH, Bengaluru 560091, Karnataka, IndiaDepartment of Ilmul Qabalat wa Amraze Niswan, National Institute of Unani Medicine, Ministry of AYUSH, Bengaluru 560091, Karnataka, IndiaSchool of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu 611731, ChinaDepartment of Ilmul Qabalat wa Amraze Niswan, National Institute of Unani Medicine, Ministry of AYUSH, Bengaluru 560091, Karnataka, IndiaHigher Polytechnic School, Universidad Europea Del Atlántico, Isabel Torres 21, 39011 Santander, SpainDepartment of Project Management, Universidad Internacional Iberoamericana, Campeche 24560, MexicoDepartment of Signal Theory and Communications and Telematic Engineering, University of Valladolid, Paseo de Belén 15, 47011 Valladolid, SpainHerbal medicine and nutritional supplements are suggested to treat premenstrual somatic and psycho-behavioural symptoms in clinical guidelines; nonetheless, this is at present based on poor-quality trial evidence. Hence, we aimed to design a systematic review and meta-analysis for their effectiveness in alleviating premenstrual symptoms. The published randomized controlled trials (RCTs) were extracted from Google scholar, PubMed, Scopus and PROSPERO databases. The risk of bias in randomized trials was assessed by Cochrane risk-of-bias tool. The main outcome parameters were analysed separately based on the Premenstrual Symptom Screening Tool and PMTS and DRSP scores. Secondary parameters of somatic, psychological, and behavioural subscale symptoms of PSST were also analysed. Data synthesis was performed assuming a random-effects model, and standardized mean difference (SMDs) was analysed using SPSS version 28.0.0 (IBM, Armonk, NY, USA). A total of 754 articles were screened, and 15 RCTs were included (<i>n</i> = 1211 patients). Primary results for participants randomized to an intervention reported reduced PSST (<i>n</i> = 9), PMTS (<i>n</i> = 2), and DSR (<i>n</i> = 4) scores with (SMD = −1.44; 95% CI: −1.72 to −1.17), (SMD = −1.69; 95% CI: −3.80 to 0.42) and (SMD = 2.86; 95% CI: 1.02 to 4.69) verses comparator with substantial heterogeneity. Physical (SMD = −1.61; 95% CI = −2.56 to −0.66), behavioural (SMD = −0.60; 95% CI = −1.55 to 0.35) and mood (SMD = 0.57; 95% CI = −0.96 to 2.11) subscale symptom groupings of PSST displayed similar findings. Fifty-three studies (<i>n</i> = 8) were considered at low risk of bias with high quality. Mild adverse events were reported by four RCTs. Based on the existing evidence, herbal medicine and nutritional supplements may be effective and safe for PMS.https://www.mdpi.com/1424-8247/15/11/1371dietary supplementsfemale healthherbal medicinePMSPRISMAreproductive health |
| spellingShingle | Arshiya Sultana Md Belal Bin Heyat Khaleequr Rahman Radhika Kunnavil Mohamed Joonus Aynul Fazmiya Faijan Akhtar Sumbul Juan Luis Vidal Mazón Carmen Lili Rodríguez Isabel De La Torre Díez A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements Pharmaceuticals dietary supplements female health herbal medicine PMS PRISMA reproductive health |
| title | A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements |
| title_full | A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements |
| title_fullStr | A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements |
| title_full_unstemmed | A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements |
| title_short | A Systematic Review and Meta-Analysis of Premenstrual Syndrome with Special Emphasis on Herbal Medicine and Nutritional Supplements |
| title_sort | systematic review and meta analysis of premenstrual syndrome with special emphasis on herbal medicine and nutritional supplements |
| topic | dietary supplements female health herbal medicine PMS PRISMA reproductive health |
| url | https://www.mdpi.com/1424-8247/15/11/1371 |
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