Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up
Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019 (COVID-19) exhibit anxiety, depression, and altered brain microstructure, their long-term physical problems, neuropsychiatric sequelae, and changes in brain function remain unknown. This o...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=7;spage=1576;epage=1581;aulast=Du |
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| author | Yan-Yao Du Wei Zhao Xiang-Lin Zhou Mu Zeng Dan-Hui Yang Xing-Zhi Xie Si-Hong Huang Ying-Jia Jiang Wen-Han Yang Hu Guo Hui Sun Ji-Yang Liu Ping Liu Zhi-Guo Zhou Hong Luo Jun Liu |
| author_facet | Yan-Yao Du Wei Zhao Xiang-Lin Zhou Mu Zeng Dan-Hui Yang Xing-Zhi Xie Si-Hong Huang Ying-Jia Jiang Wen-Han Yang Hu Guo Hui Sun Ji-Yang Liu Ping Liu Zhi-Guo Zhou Hong Luo Jun Liu |
| author_sort | Yan-Yao Du |
| collection | DOAJ |
| description | Although some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019 (COVID-19) exhibit anxiety, depression, and altered brain microstructure, their long-term physical problems, neuropsychiatric sequelae, and changes in brain function remain unknown. This observational cohort study collected 1-year follow-up data from 22 patients who had been hospitalized with COVID-19 (8 males and 11 females, aged 54.2 ± 8.7 years). Fatigue and myalgia were persistent symptoms at the 1-year follow-up. The resting state functional magnetic resonance imaging revealed that compared with 29 healthy controls (7 males and 18 females, aged 50.5 ± 11.6 years), COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation (ALFF) values in the left precentral gyrus, middle frontal gyrus, inferior frontal gyrus of operculum, inferior frontal gyrus of triangle, insula, hippocampus, parahippocampal gyrus, fusiform gyrus, postcentral gyrus, inferior parietal angular gyrus, supramarginal gyrus, angular gyrus, thalamus, middle temporal gyrus, inferior temporal gyrus, caudate, and putamen. ALFF values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores, and those in the left precentral gyrus were positively correlated with neutrophil count during hospitalization. The long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 survivors. This can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric sequelae. This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University (approval No. 2020S004) on March 19, 2020. |
| first_indexed | 2024-12-20T13:20:45Z |
| format | Article |
| id | doaj.art-2ee64f57c6ec42498a15046e6275b3ff |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-20T13:20:45Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-2ee64f57c6ec42498a15046e6275b3ff2022-12-21T19:39:24ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742022-01-011771576158110.4103/1673-5374.327361Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-upYan-Yao DuWei ZhaoXiang-Lin ZhouMu ZengDan-Hui YangXing-Zhi XieSi-Hong HuangYing-Jia JiangWen-Han YangHu GuoHui SunJi-Yang LiuPing LiuZhi-Guo ZhouHong LuoJun LiuAlthough some short-term follow-up studies have found that individuals recovering from coronavirus disease 2019 (COVID-19) exhibit anxiety, depression, and altered brain microstructure, their long-term physical problems, neuropsychiatric sequelae, and changes in brain function remain unknown. This observational cohort study collected 1-year follow-up data from 22 patients who had been hospitalized with COVID-19 (8 males and 11 females, aged 54.2 ± 8.7 years). Fatigue and myalgia were persistent symptoms at the 1-year follow-up. The resting state functional magnetic resonance imaging revealed that compared with 29 healthy controls (7 males and 18 females, aged 50.5 ± 11.6 years), COVID-19 survivors had greatly increased amplitude of low-frequency fluctuation (ALFF) values in the left precentral gyrus, middle frontal gyrus, inferior frontal gyrus of operculum, inferior frontal gyrus of triangle, insula, hippocampus, parahippocampal gyrus, fusiform gyrus, postcentral gyrus, inferior parietal angular gyrus, supramarginal gyrus, angular gyrus, thalamus, middle temporal gyrus, inferior temporal gyrus, caudate, and putamen. ALFF values in the left caudate of the COVID-19 survivors were positively correlated with their Athens Insomnia Scale scores, and those in the left precentral gyrus were positively correlated with neutrophil count during hospitalization. The long-term follow-up results suggest that the ALFF in brain regions related to mood and sleep regulation were altered in COVID-19 survivors. This can help us understand the neurobiological mechanisms of COVID-19-related neuropsychiatric sequelae. This study was approved by the Ethics Committee of the Second Xiangya Hospital of Central South University (approval No. 2020S004) on March 19, 2020.http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=7;spage=1576;epage=1581;aulast=Duamplitude of low-frequency fluctuation; clinical study; coronavirus disease 2019; follow-up; functional magnetic resonance imaging; long-term physical consequences; neuropsychiatric sequelae; resting-state function |
| spellingShingle | Yan-Yao Du Wei Zhao Xiang-Lin Zhou Mu Zeng Dan-Hui Yang Xing-Zhi Xie Si-Hong Huang Ying-Jia Jiang Wen-Han Yang Hu Guo Hui Sun Ji-Yang Liu Ping Liu Zhi-Guo Zhou Hong Luo Jun Liu Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up Neural Regeneration Research amplitude of low-frequency fluctuation; clinical study; coronavirus disease 2019; follow-up; functional magnetic resonance imaging; long-term physical consequences; neuropsychiatric sequelae; resting-state function |
| title | Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up |
| title_full | Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up |
| title_fullStr | Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up |
| title_full_unstemmed | Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up |
| title_short | Survivors of COVID-19 exhibit altered amplitudes of low frequency fluctuation in the brain: a resting-state functional magnetic resonance imaging study at 1-year follow-up |
| title_sort | survivors of covid 19 exhibit altered amplitudes of low frequency fluctuation in the brain a resting state functional magnetic resonance imaging study at 1 year follow up |
| topic | amplitude of low-frequency fluctuation; clinical study; coronavirus disease 2019; follow-up; functional magnetic resonance imaging; long-term physical consequences; neuropsychiatric sequelae; resting-state function |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=7;spage=1576;epage=1581;aulast=Du |
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