Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation

Phosphodiesterase 4 inhibition after retrieval switches the memory fate favoring extinction instead of reconsolidation

Abstract Phosphodiesterase 4 (PDE4), an enzyme expressed in the dorsal hippocampus (DH), hydrolyzes the cAMP, limiting the PKA-induced CREB phosphorylation (pCREB) and BDNF expression. Depending on the brain region, PKA and pCREB mediate reconsolidation or extinction, whereas BDNF is mainly related...

Full description

Bibliographic Details
Main Authors: Jeferson Machado Batista Sohn, Nathalie Carla Cardoso, Ana Maria Raymundi, Jos Prickaerts, Cristina Aparecida Jark Stern
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47717-1

Similar Items

Similar Items