Diurnal Variations in Vascular Endothelial Vasodilation Are Influenced by Chronotype in Healthy Humans
Introduction: The time of day when cardiovascular events are most likely to occur is thought to be aligned with the circadian rhythm of physiological variables. Chronotype has been shown to influence the time of day when cardiovascular events happen, with early chronotypes reported to be more suscep...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00901/full |
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| author | Elise R. Facer-Childs Elise R. Facer-Childs Elise R. Facer-Childs Elise R. Facer-Childs Katie Pake Vivian Y. Lee Samuel J. E. Lucas Samuel J. E. Lucas George M. Balanos |
| author_facet | Elise R. Facer-Childs Elise R. Facer-Childs Elise R. Facer-Childs Elise R. Facer-Childs Katie Pake Vivian Y. Lee Samuel J. E. Lucas Samuel J. E. Lucas George M. Balanos |
| author_sort | Elise R. Facer-Childs |
| collection | DOAJ |
| description | Introduction: The time of day when cardiovascular events are most likely to occur is thought to be aligned with the circadian rhythm of physiological variables. Chronotype has been shown to influence the time of day when cardiovascular events happen, with early chronotypes reported to be more susceptible in the morning and late chronotypes in the evening. However, no studies have investigated the influence of chronotype on physiological variables responsible for cardiovascular regulation in healthy individuals.Methods: 312 individuals completed the Munich ChronoType Questionnaire to assess chronotype. Twenty participants were randomly selected to continue into the main study. In a repeated-measures experiment, participants were tested between 08:00 and 10:00 h and again between 18:00 and 20:00 h. Measurements of mean arterial pressure, heart rate and vascular endothelial vasodilation via flow-mediated dilatation (FMD) were obtained at each session.Results: Individual diurnal differences in mean arterial pressure and heart rate show no significant relationship with chronotype. Diurnal differences in FMD showed a significant correlation (p = 0.010), driven by a clear significant relationship in the evening and not the morning (p < 0.001).Conclusion: These preliminary data indicate that chronotype influences the diurnal variation of endothelial vasodilation measured using flow-mediated dilatation. Furthermore, we show that the influence of chronotype is much stronger in the evening, highlighting an increased susceptibility for later types. These findings are consistent with the diurnal rhythm in cardiovascular events and uncover potential mechanisms of local mediators that may underpin the influence of chronotype in the onset of these events. |
| first_indexed | 2024-12-14T10:12:34Z |
| format | Article |
| id | doaj.art-2ee670786dd04193b148226da02b4182 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-14T10:12:34Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-2ee670786dd04193b148226da02b41822022-12-21T23:06:57ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-07-011010.3389/fphys.2019.00901447329Diurnal Variations in Vascular Endothelial Vasodilation Are Influenced by Chronotype in Healthy HumansElise R. Facer-Childs0Elise R. Facer-Childs1Elise R. Facer-Childs2Elise R. Facer-Childs3Katie Pake4Vivian Y. Lee5Samuel J. E. Lucas6Samuel J. E. Lucas7George M. Balanos8School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomSchool of Psychology, University of Birmingham, Birmingham, United KingdomCentre for Human Brain Health, University of Birmingham, Birmingham, United KingdomTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, AustraliaSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomCentre for Human Brain Health, University of Birmingham, Birmingham, United KingdomSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United KingdomIntroduction: The time of day when cardiovascular events are most likely to occur is thought to be aligned with the circadian rhythm of physiological variables. Chronotype has been shown to influence the time of day when cardiovascular events happen, with early chronotypes reported to be more susceptible in the morning and late chronotypes in the evening. However, no studies have investigated the influence of chronotype on physiological variables responsible for cardiovascular regulation in healthy individuals.Methods: 312 individuals completed the Munich ChronoType Questionnaire to assess chronotype. Twenty participants were randomly selected to continue into the main study. In a repeated-measures experiment, participants were tested between 08:00 and 10:00 h and again between 18:00 and 20:00 h. Measurements of mean arterial pressure, heart rate and vascular endothelial vasodilation via flow-mediated dilatation (FMD) were obtained at each session.Results: Individual diurnal differences in mean arterial pressure and heart rate show no significant relationship with chronotype. Diurnal differences in FMD showed a significant correlation (p = 0.010), driven by a clear significant relationship in the evening and not the morning (p < 0.001).Conclusion: These preliminary data indicate that chronotype influences the diurnal variation of endothelial vasodilation measured using flow-mediated dilatation. Furthermore, we show that the influence of chronotype is much stronger in the evening, highlighting an increased susceptibility for later types. These findings are consistent with the diurnal rhythm in cardiovascular events and uncover potential mechanisms of local mediators that may underpin the influence of chronotype in the onset of these events.https://www.frontiersin.org/article/10.3389/fphys.2019.00901/fullchronotypesleepflow-mediated dilatationvascular endothelial functiondiurnal variationcardiovascular regulation |
| spellingShingle | Elise R. Facer-Childs Elise R. Facer-Childs Elise R. Facer-Childs Elise R. Facer-Childs Katie Pake Vivian Y. Lee Samuel J. E. Lucas Samuel J. E. Lucas George M. Balanos Diurnal Variations in Vascular Endothelial Vasodilation Are Influenced by Chronotype in Healthy Humans Frontiers in Physiology chronotype sleep flow-mediated dilatation vascular endothelial function diurnal variation cardiovascular regulation |
| title | Diurnal Variations in Vascular Endothelial Vasodilation Are Influenced by Chronotype in Healthy Humans |
| title_full | Diurnal Variations in Vascular Endothelial Vasodilation Are Influenced by Chronotype in Healthy Humans |
| title_fullStr | Diurnal Variations in Vascular Endothelial Vasodilation Are Influenced by Chronotype in Healthy Humans |
| title_full_unstemmed | Diurnal Variations in Vascular Endothelial Vasodilation Are Influenced by Chronotype in Healthy Humans |
| title_short | Diurnal Variations in Vascular Endothelial Vasodilation Are Influenced by Chronotype in Healthy Humans |
| title_sort | diurnal variations in vascular endothelial vasodilation are influenced by chronotype in healthy humans |
| topic | chronotype sleep flow-mediated dilatation vascular endothelial function diurnal variation cardiovascular regulation |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00901/full |
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