Resveratrol: Potential Application in Sepsis
Sepsis is a life-threatening organ dysfunction syndrome caused by host response disorders due to infection or infectious factors and is a common complication of patients with clinical trauma, burns, and infection. Resveratrol is a natural polyphenol compound that is a SIRT-1 activator with anti-infl...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-02-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.821358/full |
| _version_ | 1819274350157627392 |
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| author | Jiajia Li Xiaoting Zeng Fuxun Yang Lan Wang Xiaoxiu Luo Rongan Liu Fan Zeng Sen Lu Xiaobo Huang Yu Lei Yunping Lan |
| author_facet | Jiajia Li Xiaoting Zeng Fuxun Yang Lan Wang Xiaoxiu Luo Rongan Liu Fan Zeng Sen Lu Xiaobo Huang Yu Lei Yunping Lan |
| author_sort | Jiajia Li |
| collection | DOAJ |
| description | Sepsis is a life-threatening organ dysfunction syndrome caused by host response disorders due to infection or infectious factors and is a common complication of patients with clinical trauma, burns, and infection. Resveratrol is a natural polyphenol compound that is a SIRT-1 activator with anti-inflammatory, antiviral, antibacterial, antifungal inhibitory abilities as well as cardiovascular and anti-tumor protective effects. In recent years, some scholars have applied resveratrol in animal models of sepsis and found that it has an organ protective effect and can improve the survival time and reduce the mortality of animals with sepsis. In this study, Medline (Pubmed), embase, and other databases were searched to retrieve literature published in 2021 using the keywords “resveratrol” and “sepsis,” and then the potential of resveratrol for the treatment of sepsis was reviewed and prospected to provide some basis for future clinical research. |
| first_indexed | 2024-12-23T23:07:02Z |
| format | Article |
| id | doaj.art-2ee6804f2dcb46a89565fa1d6ea000c4 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-23T23:07:02Z |
| publishDate | 2022-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2ee6804f2dcb46a89565fa1d6ea000c42022-12-21T17:26:47ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-02-011310.3389/fphar.2022.821358821358Resveratrol: Potential Application in SepsisJiajia LiXiaoting ZengFuxun YangLan WangXiaoxiu LuoRongan LiuFan ZengSen LuXiaobo HuangYu LeiYunping LanSepsis is a life-threatening organ dysfunction syndrome caused by host response disorders due to infection or infectious factors and is a common complication of patients with clinical trauma, burns, and infection. Resveratrol is a natural polyphenol compound that is a SIRT-1 activator with anti-inflammatory, antiviral, antibacterial, antifungal inhibitory abilities as well as cardiovascular and anti-tumor protective effects. In recent years, some scholars have applied resveratrol in animal models of sepsis and found that it has an organ protective effect and can improve the survival time and reduce the mortality of animals with sepsis. In this study, Medline (Pubmed), embase, and other databases were searched to retrieve literature published in 2021 using the keywords “resveratrol” and “sepsis,” and then the potential of resveratrol for the treatment of sepsis was reviewed and prospected to provide some basis for future clinical research.https://www.frontiersin.org/articles/10.3389/fphar.2022.821358/fullsepsisresveratrolorgan protectionantioxidationSIRT-1animal model |
| spellingShingle | Jiajia Li Xiaoting Zeng Fuxun Yang Lan Wang Xiaoxiu Luo Rongan Liu Fan Zeng Sen Lu Xiaobo Huang Yu Lei Yunping Lan Resveratrol: Potential Application in Sepsis Frontiers in Pharmacology sepsis resveratrol organ protection antioxidation SIRT-1 animal model |
| title | Resveratrol: Potential Application in Sepsis |
| title_full | Resveratrol: Potential Application in Sepsis |
| title_fullStr | Resveratrol: Potential Application in Sepsis |
| title_full_unstemmed | Resveratrol: Potential Application in Sepsis |
| title_short | Resveratrol: Potential Application in Sepsis |
| title_sort | resveratrol potential application in sepsis |
| topic | sepsis resveratrol organ protection antioxidation SIRT-1 animal model |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.821358/full |
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