The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate
Plasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1P guide lymphocyte egress from lymphoid organs. S1P is made intracellularly, and little is known about how S1P is delivered into circulatory fluids. Here, we find that mice without the major facilitator supe...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-11-01
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| Series: | Cell Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124712003257 |
| _version_ | 1817994251780227072 |
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| author | Alejandra Mendoza Béatrice Bréart Willy D. Ramos-Perez Lauren A. Pitt Michael Gobert Manjula Sunkara Juan J. Lafaille Andrew J. Morris Susan R. Schwab |
| author_facet | Alejandra Mendoza Béatrice Bréart Willy D. Ramos-Perez Lauren A. Pitt Michael Gobert Manjula Sunkara Juan J. Lafaille Andrew J. Morris Susan R. Schwab |
| author_sort | Alejandra Mendoza |
| collection | DOAJ |
| description | Plasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1P guide lymphocyte egress from lymphoid organs. S1P is made intracellularly, and little is known about how S1P is delivered into circulatory fluids. Here, we find that mice without the major facilitator superfamily transporter Spns2 have a profound reduction in lymph S1P, but only a minor decrease in plasma S1P. Spns2-deficient mice have a redistribution of lymphocytes from the spleen to lymph nodes and a loss of circulating lymphocytes, consistent with normal egress from the spleen directed by plasma S1P and blocked egress from lymph nodes directed by lymph S1P. Spns2 is needed in endothelial cells to supply lymph S1P and support lymphocyte circulation. As a differential requirement for lymph and blood S1P, Spns2 may be an attractive target for immune suppressive drugs. |
| first_indexed | 2024-04-14T01:50:33Z |
| format | Article |
| id | doaj.art-2ee8f61c589d47f4a343c861eed15190 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-14T01:50:33Z |
| publishDate | 2012-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-2ee8f61c589d47f4a343c861eed151902022-12-22T02:19:22ZengElsevierCell Reports2211-12472012-11-01251104111010.1016/j.celrep.2012.09.021The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-PhosphateAlejandra Mendoza0Béatrice Bréart1Willy D. Ramos-Perez2Lauren A. Pitt3Michael Gobert4Manjula Sunkara5Juan J. Lafaille6Andrew J. Morris7Susan R. Schwab8Program in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USAProgram in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USAProgram in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USAProgram in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USAProgram in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USADivision of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, 40536, USAProgram in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USADivision of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, 40536, USAProgram in Molecular Pathogenesis and Department of Pathology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USAPlasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1P guide lymphocyte egress from lymphoid organs. S1P is made intracellularly, and little is known about how S1P is delivered into circulatory fluids. Here, we find that mice without the major facilitator superfamily transporter Spns2 have a profound reduction in lymph S1P, but only a minor decrease in plasma S1P. Spns2-deficient mice have a redistribution of lymphocytes from the spleen to lymph nodes and a loss of circulating lymphocytes, consistent with normal egress from the spleen directed by plasma S1P and blocked egress from lymph nodes directed by lymph S1P. Spns2 is needed in endothelial cells to supply lymph S1P and support lymphocyte circulation. As a differential requirement for lymph and blood S1P, Spns2 may be an attractive target for immune suppressive drugs.http://www.sciencedirect.com/science/article/pii/S2211124712003257 |
| spellingShingle | Alejandra Mendoza Béatrice Bréart Willy D. Ramos-Perez Lauren A. Pitt Michael Gobert Manjula Sunkara Juan J. Lafaille Andrew J. Morris Susan R. Schwab The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate Cell Reports |
| title | The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate |
| title_full | The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate |
| title_fullStr | The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate |
| title_full_unstemmed | The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate |
| title_short | The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate |
| title_sort | transporter spns2 is required for secretion of lymph but not plasma sphingosine 1 phosphate |
| url | http://www.sciencedirect.com/science/article/pii/S2211124712003257 |
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