The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

Plasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1P guide lymphocyte egress from lymphoid organs. S1P is made intracellularly, and little is known about how S1P is delivered into circulatory fluids. Here, we find that mice without the major facilitator supe...

Full description

Bibliographic Details
Main Authors:	Alejandra Mendoza, Béatrice Bréart, Willy D. Ramos-Perez, Lauren A. Pitt, Michael Gobert, Manjula Sunkara, Juan J. Lafaille, Andrew J. Morris, Susan R. Schwab
Format:	Article
Language:	English
Published:	Elsevier 2012-11-01
Series:	Cell Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124712003257

Similar Items

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
by: Li, HZ, et al.
Published: (2025)

Transport and inhibition of the sphingosine-1-phosphate exporter SPNS2
by: Huanyu Z. Li, et al.
Published: (2025-01-01)

New insights into functions of the sphingosine-1-phosphate transporter SPNS2
by: Sarah Spiegel, et al.
Published: (2019-03-01)

Assay of Sphingosine 1-phosphate Transporter Spinster Homolog 2 (Spns2) Inhibitors
by: Yugesh Kharel, et al.
Published: (2023-09-01)

Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells.
by: Yu Hisano, et al.
Published: (2012-01-01)

Critical role of Spns2, a sphingosine-1-phosphate transporter, in lung cancer cell survival and migration.
by: Eric Bradley, et al.
Published: (2014-01-01)

Multiset-Algebraic Cryptanalysis of Reduced Kuznyechik, Khazad, and secret SPNs
by: Alex Biryukov, et al.
Published: (2017-02-01)

Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate
by: Matthew G.K. Benesch, et al.
Published: (2015-06-01)

Sphingosine 1-phosphate: a novel stimulator of aldosterone secretion
by: Leyre Brizuela, et al.
Published: (2006-06-01)

The sphingosine‐1‐phosphate signaling pathway (sphingosine‐1‐phosphate and its receptor, sphingosine kinase) and epilepsy
by: Lin Wang, et al.
Published: (2025-02-01)

Broad and diverse roles of sphingosine-1-phosphate/sphingosine-1-phosphate receptors in the prostate
by: Daoquan Liu, et al.
Published: (2024-12-01)

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis
by: Kana Masuda-Kuroki, et al.
Published: (2023-09-01)

Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets
by: Motohiro Tani, et al.
Published: (2005-11-01)

Evaluasi Sistem Informasi Penjualan PT SPNS
by: Anderes Gui, et al.
Published: (2010-06-01)

Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels.
by: Kirsi Riento, et al.
Published: (2018-01-01)

Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System
by: Alessandro Cannavo, et al.
Published: (2017-08-01)

Synthesis of sphingosine-1-phosphate and dihydrosphingosine-1-phosphate.
by: A Boumendjel, et al.
Published: (1994-12-01)

Sphingosine 1-phosphate activation of ERM contributes to vascular calcification[S]
by: Thomas G. Morris, et al.
Published: (2018-01-01)

Biodegradable semiconducting polymer nanoparticles (spns) in theranostic application
by: Nur Hafizah Zulkifli
Published: (2018)

Sphingosine 1-Phosphate in Renal Diseases
by: Alexander Koch, et al.
Published: (2013-05-01)

Deficiency of sphingosine-1-phosphate receptor 3 does not affect the skeletal phenotype of mice lacking sphingosine-1-phosphate lyase.
by: Timo Heckt, et al.
Published: (2019-01-01)

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1
by: Amin Polzin, et al.
Published: (2023-02-01)

Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2*
by: Hitoshi Ikeda, et al.
Published: (2009-03-01)

Sphingosine‐1‐phosphate as a key player of insulin secretion induced by high‐density lipoprotein treatment
by: Marie‐Claude Brulhart‐Meynet, et al.
Published: (2021-03-01)

Targeting sphingosine 1-phosphate and sphingosine kinases in pancreatic cancer: mechanisms and therapeutic potential
by: Khem Raj Limbu, et al.
Published: (2024-10-01)

Impairment of Angiogenic Sphingosine Kinase-1/Sphingosine-1-Phosphate Receptors Pathway in Preeclampsia.
by: Aneta Dobierzewska, et al.
Published: (2016-01-01)

Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases
by: Na Wang, et al.
Published: (2023-05-01)

Neurological Consequences of Sphingosine Phosphate Lyase Insufficiency
by: Krishan B. Atreya, et al.
Published: (2022-09-01)

Plasma sphingosine-1-phosphate is elevated in obesity.
by: Greg M Kowalski, et al.
Published: (2013-01-01)

Sphingosine-1-Phosphate: Boon and Bane for the Brain
by: Gerhild van Echten-Deckert, et al.
Published: (2014-06-01)

Roles of sphingosine-1-phosphate signaling in cancer
by: Peng Wang, et al.
Published: (2019-11-01)

Export of sphingosine-1-phosphate and cancer progression
by: Kazuaki Takabe, et al.
Published: (2014-09-01)

An update on the biology of sphingosine 1-phosphate receptors
by: Victoria A. Blaho, et al.
Published: (2014-08-01)

Sphingosine 1-phosphate in acute dengue infection.
by: Laksiri Gomes, et al.
Published: (2014-01-01)

Sphingosine-1-phosphate receptor 3 mediates sphingosine-1-phosphate induced release of weibel-palade bodies from endothelial cells.
by: Kathinka W E M van Hooren, et al.
Published: (2014-01-01)

The Role of Sphingosine-1-Phosphate and Ceramide-1-Phosphate in Inflammation and Cancer
by: Nitai C. Hait, et al.
Published: (2017-01-01)

Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen.
by: Arnon, T, et al.
Published: (2014)

Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate
by: Jefri Jeya Paul, et al.
Published: (2020-04-01)

Sphingosine 1-Phosphate Receptor 1 Signaling in Mammalian Cells
by: Nigel J. Pyne, et al.
Published: (2017-02-01)

Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development
by: Yu Hisano, et al.
Published: (2013-06-01)