The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

The Transporter Spns2 Is Required for Secretion of Lymph but Not Plasma Sphingosine-1-Phosphate

Plasma sphingosine-1-phosphate (S1P) regulates vascular permeability, and plasma and lymph S1P guide lymphocyte egress from lymphoid organs. S1P is made intracellularly, and little is known about how S1P is delivered into circulatory fluids. Here, we find that mice without the major facilitator supe...

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Bibliographic Details
Main Authors: Alejandra Mendoza, Béatrice Bréart, Willy D. Ramos-Perez, Lauren A. Pitt, Michael Gobert, Manjula Sunkara, Juan J. Lafaille, Andrew J. Morris, Susan R. Schwab
Format: Article
Language:English
Published: Elsevier 2012-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712003257

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