Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease
Objective: To present a critical review of publications reporting on the rationale and clinical implications of the use of biomarkers for the early diagnosis of Alzheimer's disease (AD). Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Psiquiatria (ABP)
2013-09-01
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| Series: | Brazilian Journal of Psychiatry |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000300284&lng=en&tlng=en |
| _version_ | 1818137255647117312 |
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| author | Orestes V. Forlenza Breno S. Diniz Antonio L. Teixeira Florindo Stella Wagner Gattaz |
| author_facet | Orestes V. Forlenza Breno S. Diniz Antonio L. Teixeira Florindo Stella Wagner Gattaz |
| author_sort | Orestes V. Forlenza |
| collection | DOAJ |
| description | Objective: To present a critical review of publications reporting on the rationale and clinical implications of the use of biomarkers for the early diagnosis of Alzheimer's disease (AD). Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012, and based on the following terms: mild cognitive impairment, Alzheimer's disease OR dementia, biomarkers. We retrieved 1,130 articles, of which 175 were reviews. Overall, 955 original articles were eligible. Results: The following points were considered relevant for the present review: a) rationale for biomarkers research in AD and mild cognitive impairment (MCI); b) usefulness of distinct biomarkers for the diagnosis and prediction of AD; c) the role of multimodality biomarkers for the diagnosis and prediction of AD; d) the role of biomarkers in clinical trials of patients with AD and MCI; and e) current limitations to the widespread use of biomarkers in research and clinical settings. Conclusion: Different biomarkers are useful for the early diagnosis and prediction of AD in at-risk subjects. Nonetheless, important methodological limitations need to be overcome for widespread use of biomarkers in research and clinical settings. |
| first_indexed | 2024-12-11T09:53:24Z |
| format | Article |
| id | doaj.art-2eeac9164dd94f70b1062510ba94c689 |
| institution | Directory Open Access Journal |
| issn | 1809-452X |
| language | English |
| last_indexed | 2024-12-11T09:53:24Z |
| publishDate | 2013-09-01 |
| publisher | Associação Brasileira de Psiquiatria (ABP) |
| record_format | Article |
| series | Brazilian Journal of Psychiatry |
| spelling | doaj.art-2eeac9164dd94f70b1062510ba94c6892022-12-22T01:12:19ZengAssociação Brasileira de Psiquiatria (ABP)Brazilian Journal of Psychiatry1809-452X2013-09-0135328429410.1590/1516-4446-2012-3505S1516-44462013000300284Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's diseaseOrestes V. ForlenzaBreno S. DinizAntonio L. TeixeiraFlorindo StellaWagner GattazObjective: To present a critical review of publications reporting on the rationale and clinical implications of the use of biomarkers for the early diagnosis of Alzheimer's disease (AD). Methods: We conducted a systematic search of the PubMed and Web of Science electronic databases, limited to articles published in English between 1999 and 2012, and based on the following terms: mild cognitive impairment, Alzheimer's disease OR dementia, biomarkers. We retrieved 1,130 articles, of which 175 were reviews. Overall, 955 original articles were eligible. Results: The following points were considered relevant for the present review: a) rationale for biomarkers research in AD and mild cognitive impairment (MCI); b) usefulness of distinct biomarkers for the diagnosis and prediction of AD; c) the role of multimodality biomarkers for the diagnosis and prediction of AD; d) the role of biomarkers in clinical trials of patients with AD and MCI; and e) current limitations to the widespread use of biomarkers in research and clinical settings. Conclusion: Different biomarkers are useful for the early diagnosis and prediction of AD in at-risk subjects. Nonetheless, important methodological limitations need to be overcome for widespread use of biomarkers in research and clinical settings.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000300284&lng=en&tlng=enAlzheimer's diseasemild cognitive impairmentbiomarkersneuroimagingamyloid-β proteinTau protein |
| spellingShingle | Orestes V. Forlenza Breno S. Diniz Antonio L. Teixeira Florindo Stella Wagner Gattaz Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease Brazilian Journal of Psychiatry Alzheimer's disease mild cognitive impairment biomarkers neuroimaging amyloid-β protein Tau protein |
| title | Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease |
| title_full | Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease |
| title_fullStr | Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease |
| title_full_unstemmed | Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease |
| title_short | Mild cognitive impairment (part 2): biological markers for diagnosis and prediction of dementia in Alzheimer's disease |
| title_sort | mild cognitive impairment part 2 biological markers for diagnosis and prediction of dementia in alzheimer s disease |
| topic | Alzheimer's disease mild cognitive impairment biomarkers neuroimaging amyloid-β protein Tau protein |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000300284&lng=en&tlng=en |
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