The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study
Abstract Background A major hand-foot-and-mouth disease (HFMD) pathogen, coxsackievirus A16 (CVA16), has predominated in several of the last 10 years and caused the largest number of HFMD outbreaks between 2011 and 2018 in China. We evaluated the efficacy of maternal anti-CVA16 antibody transfer via...
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| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Medicine |
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| Online Access: | https://doi.org/10.1186/s12916-022-02604-w |
| _version_ | 1797988472903958528 |
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| author | Jiaxin Zhou Yonghong Zhou Kaiwei Luo Qiaohong Liao Wen Zheng Hui Gong Huilin Shi Shanlu Zhao Kai Wang Qi Qiu Bingbing Dai Lingshuang Ren Lili Wang Lidong Gao Meng Xu Nuolan Liu Wanying Lu Nan Zheng Xinhua Chen Zhiyuan Chen Juan Yang Simon Cauchemez Hongjie Yu |
| author_facet | Jiaxin Zhou Yonghong Zhou Kaiwei Luo Qiaohong Liao Wen Zheng Hui Gong Huilin Shi Shanlu Zhao Kai Wang Qi Qiu Bingbing Dai Lingshuang Ren Lili Wang Lidong Gao Meng Xu Nuolan Liu Wanying Lu Nan Zheng Xinhua Chen Zhiyuan Chen Juan Yang Simon Cauchemez Hongjie Yu |
| author_sort | Jiaxin Zhou |
| collection | DOAJ |
| description | Abstract Background A major hand-foot-and-mouth disease (HFMD) pathogen, coxsackievirus A16 (CVA16), has predominated in several of the last 10 years and caused the largest number of HFMD outbreaks between 2011 and 2018 in China. We evaluated the efficacy of maternal anti-CVA16 antibody transfer via the placenta and explored the dynamics of maternal and natural infection-induced neutralizing antibodies in children. Methods Two population-based longitudinal cohorts in southern China were studied during 2013–2018. Participants were enrolled in autumn 2013, including 2475 children aged 1–9 years old and 1066 mother-neonate pairs, and followed for 3 years. Blood/cord samples were collected for CVA16-neutralizing antibody detection. The maternal antibody transfer efficacy, age-specific seroprevalence, geometric mean titre (GMT) and immune response kinetics were estimated. Results The average maternal antibody transfer ratio was 0.88 (95% CI 0.80–0.96). Transferred maternal antibody levels declined rapidly (half-life: 2.0 months, 95% CI 1.9–2.2 months). The GMT decayed below the positive threshold (8) by 1.5 months of age. Due to natural infections, it increased above 8 after 1.4 years and reached 32 by 5 years of age, thereafter dropping slightly. Although the average duration of maternal antibody-mediated protection was < 3 months, the duration extended to 6 months on average for mothers with titres ≥ 64. Conclusions Anti-CVA16 maternal antibodies are efficiently transferred to neonates, but their levels decline quickly. Children aged 0–5 years are the main susceptible population and should be protected by CVA16 vaccination, with the optimal vaccination time between 1.5 months and 1 year of age. |
| first_indexed | 2024-04-11T08:03:25Z |
| format | Article |
| id | doaj.art-2eeb4827b00a445d827414f860c5f711 |
| institution | Directory Open Access Journal |
| issn | 1741-7015 |
| language | English |
| last_indexed | 2024-04-11T08:03:25Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj.art-2eeb4827b00a445d827414f860c5f7112022-12-22T04:35:37ZengBMCBMC Medicine1741-70152022-11-0120111110.1186/s12916-022-02604-wThe transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort studyJiaxin Zhou0Yonghong Zhou1Kaiwei Luo2Qiaohong Liao3Wen Zheng4Hui Gong5Huilin Shi6Shanlu Zhao7Kai Wang8Qi Qiu9Bingbing Dai10Lingshuang Ren11Lili Wang12Lidong Gao13Meng Xu14Nuolan Liu15Wanying Lu16Nan Zheng17Xinhua Chen18Zhiyuan Chen19Juan Yang20Simon Cauchemez21Hongjie Yu22School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationHunan Provincial Center for Disease Control and PreventionSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationHunan Provincial Center for Disease Control and PreventionSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationAnhua County Center for Disease Control and PreventionSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationHunan Provincial Center for Disease Control and PreventionSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationMathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris, UMR2000, CNRSSchool of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of EducationAbstract Background A major hand-foot-and-mouth disease (HFMD) pathogen, coxsackievirus A16 (CVA16), has predominated in several of the last 10 years and caused the largest number of HFMD outbreaks between 2011 and 2018 in China. We evaluated the efficacy of maternal anti-CVA16 antibody transfer via the placenta and explored the dynamics of maternal and natural infection-induced neutralizing antibodies in children. Methods Two population-based longitudinal cohorts in southern China were studied during 2013–2018. Participants were enrolled in autumn 2013, including 2475 children aged 1–9 years old and 1066 mother-neonate pairs, and followed for 3 years. Blood/cord samples were collected for CVA16-neutralizing antibody detection. The maternal antibody transfer efficacy, age-specific seroprevalence, geometric mean titre (GMT) and immune response kinetics were estimated. Results The average maternal antibody transfer ratio was 0.88 (95% CI 0.80–0.96). Transferred maternal antibody levels declined rapidly (half-life: 2.0 months, 95% CI 1.9–2.2 months). The GMT decayed below the positive threshold (8) by 1.5 months of age. Due to natural infections, it increased above 8 after 1.4 years and reached 32 by 5 years of age, thereafter dropping slightly. Although the average duration of maternal antibody-mediated protection was < 3 months, the duration extended to 6 months on average for mothers with titres ≥ 64. Conclusions Anti-CVA16 maternal antibodies are efficiently transferred to neonates, but their levels decline quickly. Children aged 0–5 years are the main susceptible population and should be protected by CVA16 vaccination, with the optimal vaccination time between 1.5 months and 1 year of age.https://doi.org/10.1186/s12916-022-02604-wCoxsackievirus A16 (CVA16)Transplacental transferMaternal antibodyNatural infectionAntibody kinetics |
| spellingShingle | Jiaxin Zhou Yonghong Zhou Kaiwei Luo Qiaohong Liao Wen Zheng Hui Gong Huilin Shi Shanlu Zhao Kai Wang Qi Qiu Bingbing Dai Lingshuang Ren Lili Wang Lidong Gao Meng Xu Nuolan Liu Wanying Lu Nan Zheng Xinhua Chen Zhiyuan Chen Juan Yang Simon Cauchemez Hongjie Yu The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study BMC Medicine Coxsackievirus A16 (CVA16) Transplacental transfer Maternal antibody Natural infection Antibody kinetics |
| title | The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study |
| title_full | The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study |
| title_fullStr | The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study |
| title_full_unstemmed | The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study |
| title_short | The transfer of maternal antibodies and dynamics of maternal and natural infection-induced antibodies against coxsackievirus A16 in Chinese children 0–13 years of age: a longitudinal cohort study |
| title_sort | transfer of maternal antibodies and dynamics of maternal and natural infection induced antibodies against coxsackievirus a16 in chinese children 0 13 years of age a longitudinal cohort study |
| topic | Coxsackievirus A16 (CVA16) Transplacental transfer Maternal antibody Natural infection Antibody kinetics |
| url | https://doi.org/10.1186/s12916-022-02604-w |
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