CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF Roldana platanifolia
The chemical study of Roldana platanifolia led to the isolation of β-caryophyllene, five eremophilanolides, chlorogenic acid, and a mixture of β-sitosterol-stigmasterol, β-sitosteryl glucopyranoside, and sucrose. The anti-inflammatory activities of the extracts and isolated products were tested usin...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2015-11-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000901172&lng=en&tlng=en |
| _version_ | 1811282131086737408 |
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| author | Amira Arciniegas Ana L. Pérez-Castorena Antonio Nieto-Camacho Jhon Ironzi Maldonado José Luis Villaseñor Alfonso Romo de Vivar |
| author_facet | Amira Arciniegas Ana L. Pérez-Castorena Antonio Nieto-Camacho Jhon Ironzi Maldonado José Luis Villaseñor Alfonso Romo de Vivar |
| author_sort | Amira Arciniegas |
| collection | DOAJ |
| description | The chemical study of Roldana platanifolia led to the isolation of β-caryophyllene, five eremophilanolides, chlorogenic acid, and a mixture of β-sitosterol-stigmasterol, β-sitosteryl glucopyranoside, and sucrose. The anti-inflammatory activities of the extracts and isolated products were tested using the 12-O-tetradecanoylphorbol-13-acetate (TPA) model of induced acute inflammation. The acetone and methanol extracts showed dose dependent activities (ID50 0.21 and 0.32 mg/ear, respectively), while none of the isolated compounds exhibited relevant edema inhibition. The active extracts were also evaluated with the myeloperoxidase assay technique (MPO) to determine their ability to prevent neutrophil infiltration. Results showed that the anti-inflammatory activity was related to the compound’s ability to inhibit pro-inflammatory mediators such as neutrophils. |
| first_indexed | 2024-04-13T01:46:11Z |
| format | Article |
| id | doaj.art-2eeee32aa41a48ada7568e065719a1ac |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-04-13T01:46:11Z |
| publishDate | 2015-11-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-2eeee32aa41a48ada7568e065719a1ac2022-12-22T03:08:01ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642015-11-013891172117510.5935/0100-4042.20150133S0100-40422015000901172CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF Roldana platanifoliaAmira ArciniegasAna L. Pérez-CastorenaAntonio Nieto-CamachoJhon Ironzi MaldonadoJosé Luis VillaseñorAlfonso Romo de VivarThe chemical study of Roldana platanifolia led to the isolation of β-caryophyllene, five eremophilanolides, chlorogenic acid, and a mixture of β-sitosterol-stigmasterol, β-sitosteryl glucopyranoside, and sucrose. The anti-inflammatory activities of the extracts and isolated products were tested using the 12-O-tetradecanoylphorbol-13-acetate (TPA) model of induced acute inflammation. The acetone and methanol extracts showed dose dependent activities (ID50 0.21 and 0.32 mg/ear, respectively), while none of the isolated compounds exhibited relevant edema inhibition. The active extracts were also evaluated with the myeloperoxidase assay technique (MPO) to determine their ability to prevent neutrophil infiltration. Results showed that the anti-inflammatory activity was related to the compound’s ability to inhibit pro-inflammatory mediators such as neutrophils.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000901172&lng=en&tlng=enRoldana platanifoliaSenecioneaeTussilagininaeEremophilanolides |
| spellingShingle | Amira Arciniegas Ana L. Pérez-Castorena Antonio Nieto-Camacho Jhon Ironzi Maldonado José Luis Villaseñor Alfonso Romo de Vivar CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF Roldana platanifolia Química Nova Roldana platanifolia Senecioneae Tussilagininae Eremophilanolides |
| title | CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF Roldana platanifolia |
| title_full | CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF Roldana platanifolia |
| title_fullStr | CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF Roldana platanifolia |
| title_full_unstemmed | CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF Roldana platanifolia |
| title_short | CHEMICAL COMPOSITION AND ANTI-INFLAMMATORY ACTIVITY OF Roldana platanifolia |
| title_sort | chemical composition and anti inflammatory activity of roldana platanifolia |
| topic | Roldana platanifolia Senecioneae Tussilagininae Eremophilanolides |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422015000901172&lng=en&tlng=en |
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