Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.
Nodal and BMP signals are important for establishing left-right (LR) asymmetry in vertebrates. In sea urchins, Nodal signaling prevents the formation of the rudiment on the right side. However, the opposing pathway to Nodal signaling during LR axis establishment is not clear. Here, we revealed that...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Biology |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23055827/?tool=EBI |
| _version_ | 1830179327614910464 |
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| author | Yi-Jyun Luo Yi-Hsien Su |
| author_facet | Yi-Jyun Luo Yi-Hsien Su |
| author_sort | Yi-Jyun Luo |
| collection | DOAJ |
| description | Nodal and BMP signals are important for establishing left-right (LR) asymmetry in vertebrates. In sea urchins, Nodal signaling prevents the formation of the rudiment on the right side. However, the opposing pathway to Nodal signaling during LR axis establishment is not clear. Here, we revealed that BMP signaling is activated in the left coelomic pouch, specifically in the veg2 lineage, but not in the small micromeres. By perturbing BMP activities, we demonstrated that BMP signaling is required for activating the expression of the left-sided genes and the formation of the left-sided structures. On the other hand, Nodal signals on the right side inhibit BMP signaling and control LR asymmetric separation and apoptosis of the small micromeres. Our findings show that BMP signaling is the positive signal for left-sided development in sea urchins, suggesting that the opposing roles of Nodal and BMP signals in establishing LR asymmetry are conserved in deuterostomes. |
| first_indexed | 2024-12-17T19:57:18Z |
| format | Article |
| id | doaj.art-2eefdd5c912c444cb2652cf248d52bf6 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-17T19:57:18Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-2eefdd5c912c444cb2652cf248d52bf62022-12-21T21:34:33ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852012-01-011010e100140210.1371/journal.pbio.1001402Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva.Yi-Jyun LuoYi-Hsien SuNodal and BMP signals are important for establishing left-right (LR) asymmetry in vertebrates. In sea urchins, Nodal signaling prevents the formation of the rudiment on the right side. However, the opposing pathway to Nodal signaling during LR axis establishment is not clear. Here, we revealed that BMP signaling is activated in the left coelomic pouch, specifically in the veg2 lineage, but not in the small micromeres. By perturbing BMP activities, we demonstrated that BMP signaling is required for activating the expression of the left-sided genes and the formation of the left-sided structures. On the other hand, Nodal signals on the right side inhibit BMP signaling and control LR asymmetric separation and apoptosis of the small micromeres. Our findings show that BMP signaling is the positive signal for left-sided development in sea urchins, suggesting that the opposing roles of Nodal and BMP signals in establishing LR asymmetry are conserved in deuterostomes.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23055827/?tool=EBI |
| spellingShingle | Yi-Jyun Luo Yi-Hsien Su Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. PLoS Biology |
| title | Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. |
| title_full | Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. |
| title_fullStr | Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. |
| title_full_unstemmed | Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. |
| title_short | Opposing nodal and BMP signals regulate left-right asymmetry in the sea urchin larva. |
| title_sort | opposing nodal and bmp signals regulate left right asymmetry in the sea urchin larva |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23055827/?tool=EBI |
| work_keys_str_mv | AT yijyunluo opposingnodalandbmpsignalsregulateleftrightasymmetryintheseaurchinlarva AT yihsiensu opposingnodalandbmpsignalsregulateleftrightasymmetryintheseaurchinlarva |