MicroRNA as an Early Biomarker of Neonatal Sepsis
Sepsis is a major cause of lethality in neonatal intensive care units. Despite significant advances in neonatal care and growing scientific knowledge about the disease, 4 of every 10 infants born in developed countries and suffering from sepsis die or experience considerable disability, including su...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.854324/full |
| _version_ | 1818268827595571200 |
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| author | Martin Jouza Martin Jouza Julia Bohosova Andrea Stanikova Andrea Stanikova Jakub Pecl Jakub Pecl Ondrej Slaby Ondrej Slaby Petr Jabandziev Petr Jabandziev Petr Jabandziev |
| author_facet | Martin Jouza Martin Jouza Julia Bohosova Andrea Stanikova Andrea Stanikova Jakub Pecl Jakub Pecl Ondrej Slaby Ondrej Slaby Petr Jabandziev Petr Jabandziev Petr Jabandziev |
| author_sort | Martin Jouza |
| collection | DOAJ |
| description | Sepsis is a major cause of lethality in neonatal intensive care units. Despite significant advances in neonatal care and growing scientific knowledge about the disease, 4 of every 10 infants born in developed countries and suffering from sepsis die or experience considerable disability, including substantial and permanent neurodevelopmental impairment. Pharmacological treatment strategies for neonatal sepsis remain limited and mainly based upon early initiation of antibiotics and supportive treatment. In this context, numerous clinical and serum-based markers have been evaluated for diagnosing sepsis and evaluating its severity and etiology. MicroRNAs (miRNAs) do not encode for proteins but regulate gene expression by inhibiting the translation or transcription of their target mRNAs. Recently, it was demonstrated in adult patients that miRNAs are released into the circulation and that the spectrum of circulating miRNAs is altered during various pathologic conditions, such as inflammation, infection, and sepsis. Here, we summarize current findings on the role of circulating miRNAs in the diagnosis and staging of neonatal sepsis. The conclusions point to substantial diagnostic potential, and several miRNAs have been validated independently by different teams, namely miR-16a, miR-16, miR-96-5p, miR-141, miR-181a, and miR-1184. |
| first_indexed | 2024-12-12T20:44:41Z |
| format | Article |
| id | doaj.art-2eefee6048704011ace2e9f2b17e16d5 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-12T20:44:41Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-2eefee6048704011ace2e9f2b17e16d52022-12-22T00:12:37ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-05-011010.3389/fped.2022.854324854324MicroRNA as an Early Biomarker of Neonatal SepsisMartin Jouza0Martin Jouza1Julia Bohosova2Andrea Stanikova3Andrea Stanikova4Jakub Pecl5Jakub Pecl6Ondrej Slaby7Ondrej Slaby8Petr Jabandziev9Petr Jabandziev10Petr Jabandziev11Department of Pediatrics, University Hospital Brno, Brno, CzechiaFaculty of Medicine, Masaryk University, Brno, CzechiaCentral European Institute of Technology, Masaryk University, Brno, CzechiaFaculty of Medicine, Masaryk University, Brno, CzechiaDepartment of Neonatology, University Hospital Brno, Brno, CzechiaDepartment of Pediatrics, University Hospital Brno, Brno, CzechiaFaculty of Medicine, Masaryk University, Brno, CzechiaCentral European Institute of Technology, Masaryk University, Brno, CzechiaDepartment of Biology, Faculty of Medicine, Masaryk University, Brno, CzechiaDepartment of Pediatrics, University Hospital Brno, Brno, CzechiaFaculty of Medicine, Masaryk University, Brno, CzechiaCentral European Institute of Technology, Masaryk University, Brno, CzechiaSepsis is a major cause of lethality in neonatal intensive care units. Despite significant advances in neonatal care and growing scientific knowledge about the disease, 4 of every 10 infants born in developed countries and suffering from sepsis die or experience considerable disability, including substantial and permanent neurodevelopmental impairment. Pharmacological treatment strategies for neonatal sepsis remain limited and mainly based upon early initiation of antibiotics and supportive treatment. In this context, numerous clinical and serum-based markers have been evaluated for diagnosing sepsis and evaluating its severity and etiology. MicroRNAs (miRNAs) do not encode for proteins but regulate gene expression by inhibiting the translation or transcription of their target mRNAs. Recently, it was demonstrated in adult patients that miRNAs are released into the circulation and that the spectrum of circulating miRNAs is altered during various pathologic conditions, such as inflammation, infection, and sepsis. Here, we summarize current findings on the role of circulating miRNAs in the diagnosis and staging of neonatal sepsis. The conclusions point to substantial diagnostic potential, and several miRNAs have been validated independently by different teams, namely miR-16a, miR-16, miR-96-5p, miR-141, miR-181a, and miR-1184.https://www.frontiersin.org/articles/10.3389/fped.2022.854324/fullmiRNAinflammationCRPIL-6sepsis |
| spellingShingle | Martin Jouza Martin Jouza Julia Bohosova Andrea Stanikova Andrea Stanikova Jakub Pecl Jakub Pecl Ondrej Slaby Ondrej Slaby Petr Jabandziev Petr Jabandziev Petr Jabandziev MicroRNA as an Early Biomarker of Neonatal Sepsis Frontiers in Pediatrics miRNA inflammation CRP IL-6 sepsis |
| title | MicroRNA as an Early Biomarker of Neonatal Sepsis |
| title_full | MicroRNA as an Early Biomarker of Neonatal Sepsis |
| title_fullStr | MicroRNA as an Early Biomarker of Neonatal Sepsis |
| title_full_unstemmed | MicroRNA as an Early Biomarker of Neonatal Sepsis |
| title_short | MicroRNA as an Early Biomarker of Neonatal Sepsis |
| title_sort | microrna as an early biomarker of neonatal sepsis |
| topic | miRNA inflammation CRP IL-6 sepsis |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.854324/full |
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