On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro

On the origin of germ cell neoplasia in situ: Dedifferentiation of human adult Sertoli cells in cross talk with seminoma cells in vitro

Germ cell neoplasia in situ (GCNIS) is the noninvasive precursor of testicular germ cell tumors type II, the most common cancer in young men, which originates from embryonic germ cells blocked in their maturation. GCNIS is associated with impaired Sertoli cells (SCs) that express fetal keratin 18 (K...

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Main Authors: Cornelia Fink, Nelli Baal, Jochen Wilhelm, Poonam Sarode, Roswitha Weigel, Valérie Schumacher, Daniel Nettersheim, Hubert Schorle, Carmen Schröck, Martin Bergmann, Sabine Kliesch, Monika Kressin, Rajkumar Savai
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Germ cell neoplasia in situ
Sertoli cell dedifferentiation
TCam-2 seminoma cell line
Coculture model
Microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000336

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