Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes
Rabbit muscle vesicles derived from sarcoplasmic reticulum were used as a material in studying networks of ryanodine receptors by cryo electron tomography. Three-dimensional analysis reveals the dynamical features of these networks. It was found that the connection angles were rotated along the tran...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2016-06-01
|
| Series: | European Journal of Translational Myology |
| Subjects: | |
| Online Access: | http://www.pagepressjournals.org/index.php/bam/article/view/5805 |
| _version_ | 1819027696447913984 |
|---|---|
| author | Hongli Hu Xing Meng |
| author_facet | Hongli Hu Xing Meng |
| author_sort | Hongli Hu |
| collection | DOAJ |
| description | Rabbit muscle vesicles derived from sarcoplasmic reticulum were used as a material in studying networks of ryanodine receptors by cryo electron tomography. Three-dimensional analysis reveals the dynamical features of these networks. It was found that the connection angles were rotated along the transmembrane axis of ryanodine receptors. Majority of the connections was observed at domains 6/6 of ryanodine receptors while a small group of connections were showed at domains 9/10. The flexible rotation and connection shift seem to facilitate the extension of an annular network on the wall of the sarcoplasmic reticulum in a triad. |
| first_indexed | 2024-12-21T05:46:34Z |
| format | Article |
| id | doaj.art-2ef0188abf8b48a1ae597c851f627969 |
| institution | Directory Open Access Journal |
| issn | 2037-7452 2037-7460 |
| language | English |
| last_indexed | 2024-12-21T05:46:34Z |
| publishDate | 2016-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Translational Myology |
| spelling | doaj.art-2ef0188abf8b48a1ae597c851f6279692022-12-21T19:14:06ZengPAGEPress PublicationsEuropean Journal of Translational Myology2037-74522037-74602016-06-0126210.4081/ejtm.2016.58054760Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum MembranesHongli Hu0Xing Meng1Wadsworth Centre, New York State Department of Health, Albany, NYWadsworth Centre, New York State Department of Health, Albany, NYRabbit muscle vesicles derived from sarcoplasmic reticulum were used as a material in studying networks of ryanodine receptors by cryo electron tomography. Three-dimensional analysis reveals the dynamical features of these networks. It was found that the connection angles were rotated along the transmembrane axis of ryanodine receptors. Majority of the connections was observed at domains 6/6 of ryanodine receptors while a small group of connections were showed at domains 9/10. The flexible rotation and connection shift seem to facilitate the extension of an annular network on the wall of the sarcoplasmic reticulum in a triad.http://www.pagepressjournals.org/index.php/bam/article/view/5805MuscleNetwork dynamicsRyanodine receptorsSarcoplasmic reticulum |
| spellingShingle | Hongli Hu Xing Meng Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes European Journal of Translational Myology Muscle Network dynamics Ryanodine receptors Sarcoplasmic reticulum |
| title | Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes |
| title_full | Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes |
| title_fullStr | Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes |
| title_full_unstemmed | Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes |
| title_short | Observation of Network Dynamics of Ryanodine Receptors on Skeletal Muscle Sarcoplasmic Reticulum Membranes |
| title_sort | observation of network dynamics of ryanodine receptors on skeletal muscle sarcoplasmic reticulum membranes |
| topic | Muscle Network dynamics Ryanodine receptors Sarcoplasmic reticulum |
| url | http://www.pagepressjournals.org/index.php/bam/article/view/5805 |
| work_keys_str_mv | AT honglihu observationofnetworkdynamicsofryanodinereceptorsonskeletalmusclesarcoplasmicreticulummembranes AT xingmeng observationofnetworkdynamicsofryanodinereceptorsonskeletalmusclesarcoplasmicreticulummembranes |