The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis
Abstract Background Helicobacter pylori is a gastrointestinal pathogen that infects around half of the world's population. H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally. We conducted a system...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08504-5 |
| _version_ | 1797453728414957568 |
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| author | Maryam Shirani Reza Pakzad Mohammad Hossein Haddadi Sousan Akrami Arezoo Asadi Hossein Kazemian Melika Moradi Vahab Hassan Kaviar Abolfazl Rafati Zomorodi Saeed Khoshnood Mahnaz Shafieian Ronia Tavasolian Mohsen Heidary Morteza Saki |
| author_facet | Maryam Shirani Reza Pakzad Mohammad Hossein Haddadi Sousan Akrami Arezoo Asadi Hossein Kazemian Melika Moradi Vahab Hassan Kaviar Abolfazl Rafati Zomorodi Saeed Khoshnood Mahnaz Shafieian Ronia Tavasolian Mohsen Heidary Morteza Saki |
| author_sort | Maryam Shirani |
| collection | DOAJ |
| description | Abstract Background Helicobacter pylori is a gastrointestinal pathogen that infects around half of the world's population. H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally. We conducted a systematic review and meta-analysis to assess the global prevalence of GC in H. pylori-infected individuals. Methods We performed a systematic search of the PubMed, Web of Science, and Embase databases for studies of the prevalence of GC in H. pylori-infected individuals published from 1 January 2011 to 20 April 2021. Metaprop package were used to calculate the pooled prevalence with 95% confidence interval. Random-effects model was applied to estimate the pooled prevalence. We also quantified it with the I2 index. Based on the Higgins classification approach, I2 values above 0.7 were determined as high heterogeneity. Results Among 17,438 reports screened, we assessed 1053 full-text articles for eligibility; 149 were included in the final analysis, comprising data from 32 countries. The highest and lowest prevalence was observed in America (pooled prevalence: 18.06%; 95% CI: 16.48 − 19.63; I2: 98.84%) and Africa (pooled prevalence: 9.52%; 95% CI: 5.92 − 13.12; I2: 88.39%). Among individual countries, Japan had the highest pooled prevalence of GC in H. pylori positive patients (Prevalence: 90.90%:95% CI: 83.61–95.14), whereas Sweden had the lowest prevalence (Prevalence: 0.07%; 95% CI: 0.06–0.09). The highest and lowest prevalence was observed in prospective case series (pooled prevalence: 23.13%; 95% CI: 20.41 − 25.85; I2: 97.70%) and retrospective cohort (pooled prevalence: 1.17%; 95% CI: 0.55 − 1.78; I 2: 0.10%). Conclusions H. pylori infection in GC patients varied between regions in this systematic review and meta-analysis. We observed that large amounts of GCs in developed countries are associated with H. pylori. Using these data, regional initiatives can be taken to prevent and eradicate H. pylori worldwide, thus reducing its complications. |
| first_indexed | 2024-03-09T15:27:03Z |
| format | Article |
| id | doaj.art-2ef248e258414a08825236ac8aa2b60c |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-09T15:27:03Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-2ef248e258414a08825236ac8aa2b60c2023-11-26T12:27:26ZengBMCBMC Infectious Diseases1471-23342023-08-0123113010.1186/s12879-023-08504-5The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysisMaryam Shirani0Reza Pakzad1Mohammad Hossein Haddadi2Sousan Akrami3Arezoo Asadi4Hossein Kazemian5Melika Moradi6Vahab Hassan Kaviar7Abolfazl Rafati Zomorodi8Saeed Khoshnood9Mahnaz Shafieian10Ronia Tavasolian11Mohsen Heidary12Morteza Saki13Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical SciencesDepartment of Epidemiology, Faculty of Health, Ilam University Medical SciencesClinical Microbiology Research Center, Ilam University of Medical SciencesStudents’ Scientific Research Center (SSRC), Tehran University of Medical SciencesEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical SciencesClinical Microbiology Research Center, Ilam University of Medical SciencesDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical SciencesDepartment of Medical Microbiology, Faculty of Medicine, Ilam University of Medical ScienceDepartment of Bacteriology and Virology, School of Medicine, Shiraz University of Medical SciencesStudent Research Committee, Ilam University of Medical SciencesDepartment of Midwifery, Faculty of Nursing and Midwifery, Ilam University of Medical SciencesDepartment of Medicine, Faculty of Nutrition Science, University of ChesteDepartment of Laboratory Sciences, School of Paramedical Sciences, Sabzevar University of Medical SciencesDepartment of Microbiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical SciencesAbstract Background Helicobacter pylori is a gastrointestinal pathogen that infects around half of the world's population. H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally. We conducted a systematic review and meta-analysis to assess the global prevalence of GC in H. pylori-infected individuals. Methods We performed a systematic search of the PubMed, Web of Science, and Embase databases for studies of the prevalence of GC in H. pylori-infected individuals published from 1 January 2011 to 20 April 2021. Metaprop package were used to calculate the pooled prevalence with 95% confidence interval. Random-effects model was applied to estimate the pooled prevalence. We also quantified it with the I2 index. Based on the Higgins classification approach, I2 values above 0.7 were determined as high heterogeneity. Results Among 17,438 reports screened, we assessed 1053 full-text articles for eligibility; 149 were included in the final analysis, comprising data from 32 countries. The highest and lowest prevalence was observed in America (pooled prevalence: 18.06%; 95% CI: 16.48 − 19.63; I2: 98.84%) and Africa (pooled prevalence: 9.52%; 95% CI: 5.92 − 13.12; I2: 88.39%). Among individual countries, Japan had the highest pooled prevalence of GC in H. pylori positive patients (Prevalence: 90.90%:95% CI: 83.61–95.14), whereas Sweden had the lowest prevalence (Prevalence: 0.07%; 95% CI: 0.06–0.09). The highest and lowest prevalence was observed in prospective case series (pooled prevalence: 23.13%; 95% CI: 20.41 − 25.85; I2: 97.70%) and retrospective cohort (pooled prevalence: 1.17%; 95% CI: 0.55 − 1.78; I 2: 0.10%). Conclusions H. pylori infection in GC patients varied between regions in this systematic review and meta-analysis. We observed that large amounts of GCs in developed countries are associated with H. pylori. Using these data, regional initiatives can be taken to prevent and eradicate H. pylori worldwide, thus reducing its complications.https://doi.org/10.1186/s12879-023-08504-5InfectionPrevalenceGastric cancerHelicobacter pyloriSystematic reviewMeta-analysis |
| spellingShingle | Maryam Shirani Reza Pakzad Mohammad Hossein Haddadi Sousan Akrami Arezoo Asadi Hossein Kazemian Melika Moradi Vahab Hassan Kaviar Abolfazl Rafati Zomorodi Saeed Khoshnood Mahnaz Shafieian Ronia Tavasolian Mohsen Heidary Morteza Saki The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis BMC Infectious Diseases Infection Prevalence Gastric cancer Helicobacter pylori Systematic review Meta-analysis |
| title | The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis |
| title_full | The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis |
| title_fullStr | The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis |
| title_full_unstemmed | The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis |
| title_short | The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis |
| title_sort | global prevalence of gastric cancer in helicobacter pylori infected individuals a systematic review and meta analysis |
| topic | Infection Prevalence Gastric cancer Helicobacter pylori Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12879-023-08504-5 |
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