Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis
(1) Background: Residual breast cancer after neoadjuvant chemotherapy (NAC) could have a variable image pattern on a follow-up breast magnetic resonance image (MRI). In this study, we compared the clinical outcome of breast cancer patients with different residual tumor patterns (RTP) on a breast MRI...
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MDPI AG
2022-09-01
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| Online Access: | https://www.mdpi.com/2075-4418/12/10/2294 |
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| author | Yoon Jin Cha Na Lae Eun Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Woo-Chan Park Yangkyu Lee Chang Ik Yoon |
| author_facet | Yoon Jin Cha Na Lae Eun Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Woo-Chan Park Yangkyu Lee Chang Ik Yoon |
| author_sort | Yoon Jin Cha |
| collection | DOAJ |
| description | (1) Background: Residual breast cancer after neoadjuvant chemotherapy (NAC) could have a variable image pattern on a follow-up breast magnetic resonance image (MRI). In this study, we compared the clinical outcome of breast cancer patients with different residual tumor patterns (RTP) on a breast MRI after NAC. (2) Methods: A total of 91 patients with breast cancer who received NAC and subsequent curative surgery were selected. All included patient had residual breast cancer after NAC and showed a partial response on a breast MRI. Pre- and post-treatment were reviewed by an experienced radiologist to evaluate different RTP, and classified into two groups: concentric and scattered patterns. The clinicopathologic parameters and survival outcomes [recurrence-free survival (RFS) and distant metastasis-free survival (DMFS)] were analyzed according to different RTP. (3) Results: Patients with a scattered pattern had a larger extent of pre-treated non-mass enhancement and more frequently received total mastectomy. With a median follow-up period of 37 months, RTP were not significantly associated with RFS or DMFS. (4) Conclusions: In the patients with residual breast cancer after NAC, RTP on an MRI had no effect on the patients’ clinical outcome. The curative resection of the tumor bed and securing the negative resection margins appear to be important in the treatment of patients with residual breast cancer after NAC. |
| first_indexed | 2024-03-09T20:23:05Z |
| format | Article |
| id | doaj.art-2ef35ecf49ef400db49ecde7e2dea6b0 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T20:23:05Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2ef35ecf49ef400db49ecde7e2dea6b02023-11-23T23:42:49ZengMDPI AGDiagnostics2075-44182022-09-011210229410.3390/diagnostics12102294Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and PrognosisYoon Jin Cha0Na Lae Eun1Dooreh Kim2Soong June Bae3Sung Gwe Ahn4Joon Jeong5Woo-Chan Park6Yangkyu Lee7Chang Ik Yoon8Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, KoreaDepartment of Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, KoreaDivision of Breast Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Seoul, Seoul 06591, KoreaInstitute of Breast Cancer Precision Medicine, Yonsei University College of Medicine, Seoul 06273, KoreaInstitute of Breast Cancer Precision Medicine, Yonsei University College of Medicine, Seoul 06273, KoreaInstitute of Breast Cancer Precision Medicine, Yonsei University College of Medicine, Seoul 06273, KoreaDivision of Breast Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Seoul, Seoul 06591, KoreaDepartment of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, KoreaDivision of Breast Surgery, Department of Surgery, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Seoul, Seoul 06591, Korea(1) Background: Residual breast cancer after neoadjuvant chemotherapy (NAC) could have a variable image pattern on a follow-up breast magnetic resonance image (MRI). In this study, we compared the clinical outcome of breast cancer patients with different residual tumor patterns (RTP) on a breast MRI after NAC. (2) Methods: A total of 91 patients with breast cancer who received NAC and subsequent curative surgery were selected. All included patient had residual breast cancer after NAC and showed a partial response on a breast MRI. Pre- and post-treatment were reviewed by an experienced radiologist to evaluate different RTP, and classified into two groups: concentric and scattered patterns. The clinicopathologic parameters and survival outcomes [recurrence-free survival (RFS) and distant metastasis-free survival (DMFS)] were analyzed according to different RTP. (3) Results: Patients with a scattered pattern had a larger extent of pre-treated non-mass enhancement and more frequently received total mastectomy. With a median follow-up period of 37 months, RTP were not significantly associated with RFS or DMFS. (4) Conclusions: In the patients with residual breast cancer after NAC, RTP on an MRI had no effect on the patients’ clinical outcome. The curative resection of the tumor bed and securing the negative resection margins appear to be important in the treatment of patients with residual breast cancer after NAC.https://www.mdpi.com/2075-4418/12/10/2294breast neoplasmsneoadjuvant therapymagnetic resonance imagingprognosis |
| spellingShingle | Yoon Jin Cha Na Lae Eun Dooreh Kim Soong June Bae Sung Gwe Ahn Joon Jeong Woo-Chan Park Yangkyu Lee Chang Ik Yoon Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis Diagnostics breast neoplasms neoadjuvant therapy magnetic resonance imaging prognosis |
| title | Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis |
| title_full | Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis |
| title_fullStr | Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis |
| title_full_unstemmed | Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis |
| title_short | Residual Tumor Patterns of Breast Cancer on MRI after Neo-Adjuvant Chemotherapy: Impact on Clinicopathologic Factors and Prognosis |
| title_sort | residual tumor patterns of breast cancer on mri after neo adjuvant chemotherapy impact on clinicopathologic factors and prognosis |
| topic | breast neoplasms neoadjuvant therapy magnetic resonance imaging prognosis |
| url | https://www.mdpi.com/2075-4418/12/10/2294 |
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