Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis
Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on the pathophysiology of CRS. Osteitis is frequently observed in patients with CRS,...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2021-02-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
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| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-2020-00416.pdf |
| _version_ | 1818736392637775872 |
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| author | Roza Khalmuratova Hyun-Woo Shin |
| author_facet | Roza Khalmuratova Hyun-Woo Shin |
| author_sort | Roza Khalmuratova |
| collection | DOAJ |
| description | Chronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on the pathophysiology of CRS. Osteitis is frequently observed in patients with CRS, and is associated with severe sinonasal inflammation and recalcitrant cases. The overlying inflammatory sinonasal mucosa plays a critical role in the initiation of osteitis; however, the underlying molecular mechanisms and functional significance remain unclear. Increasingly many studies have suggested that immune cells play a crucial role in the bone remodeling process in CRS. The purpose of this review is to summarize the current state of knowledge regarding the specific role of sinonasal inflammation in bone remodeling in CRS patients. |
| first_indexed | 2024-12-18T00:36:25Z |
| format | Article |
| id | doaj.art-2ef46848018a46338ef7bf2fe110e882 |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-18T00:36:25Z |
| publishDate | 2021-02-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-2ef46848018a46338ef7bf2fe110e8822022-12-21T21:27:00ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202021-02-01141434910.21053/ceo.2020.00416737Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic RhinosinusitisRoza Khalmuratova0Hyun-Woo Shin1 Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, Korea Obstructive Upper airway Research (OUaR) Laboratory, Department of Pharmacology, Seoul National University College of Medicine, Seoul, KoreaChronic rhinosinusitis (CRS) is a multifactorial and highly heterogeneous upper airway disease that affects approximately 12% of the general population. There is increasing evidence supporting the impact of osteitis on the pathophysiology of CRS. Osteitis is frequently observed in patients with CRS, and is associated with severe sinonasal inflammation and recalcitrant cases. The overlying inflammatory sinonasal mucosa plays a critical role in the initiation of osteitis; however, the underlying molecular mechanisms and functional significance remain unclear. Increasingly many studies have suggested that immune cells play a crucial role in the bone remodeling process in CRS. The purpose of this review is to summarize the current state of knowledge regarding the specific role of sinonasal inflammation in bone remodeling in CRS patients.http://www.e-ceo.org/upload/pdf/ceo-2020-00416.pdfosteitischronic rhinosinusitisinflammationosteoblastsosteoclastscytokine |
| spellingShingle | Roza Khalmuratova Hyun-Woo Shin Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis Clinical and Experimental Otorhinolaryngology osteitis chronic rhinosinusitis inflammation osteoblasts osteoclasts cytokine |
| title | Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis |
| title_full | Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis |
| title_fullStr | Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis |
| title_full_unstemmed | Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis |
| title_short | Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis |
| title_sort | crosstalk between mucosal inflammation and bone metabolism in chronic rhinosinusitis |
| topic | osteitis chronic rhinosinusitis inflammation osteoblasts osteoclasts cytokine |
| url | http://www.e-ceo.org/upload/pdf/ceo-2020-00416.pdf |
| work_keys_str_mv | AT rozakhalmuratova crosstalkbetweenmucosalinflammationandbonemetabolisminchronicrhinosinusitis AT hyunwooshin crosstalkbetweenmucosalinflammationandbonemetabolisminchronicrhinosinusitis |