ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN
Present study has revealed low diagnostic value of Mantoux test with 2 TE in detection of tuberculosis in MBT-infected children, thus requiring implementation of novel methods. Detectable activity of tuberculosis infection among observed children with low tuberculin sensitivity was found in 23.8% of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/47 |
| _version_ | 1797198149303926784 |
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| author | P. K. Iablonskiy I. F. Dovgaljuk A. A. Starshinova O. A. Iakunova |
| author_facet | P. K. Iablonskiy I. F. Dovgaljuk A. A. Starshinova O. A. Iakunova |
| author_sort | P. K. Iablonskiy |
| collection | DOAJ |
| description | Present study has revealed low diagnostic value of Mantoux test with 2 TE in detection of tuberculosis in MBT-infected children, thus requiring implementation of novel methods. Detectable activity of tuberculosis infection among observed children with low tuberculin sensitivity was found in 23.8% of cases, as revealed by Diaskin test, as compared to 42.7% cases in a group with moderate sensitivity to tuberculin. As shown by radiological data it was accompanied by enlargement of intrathoracic lymphatic nodes in 14.3% and 53.0% cases, respectively. The data obtained with Diaskin probe were confirmed by a reference QuantiFERON testing in 95% cases. Parameters of diagnostic value for Diaskin test are two-fold higher than for Mantoux test with 2 TE. Positivity for Diaskin test reflects activity of tuberculosis infection which is accompanied by clear clinical signs in 67.3% cases, and, in 80% cases, it ischaracterized by enlargement of intrathoracic lymphatic nodes as based on radiologic data, thus arranging a risk group for tuberculosis morbidity in children. Appropriate recommendations for these patients include a fullscale phthisiatric assessment and administration of well justified and adequate therapy. |
| first_indexed | 2024-03-08T05:52:27Z |
| format | Article |
| id | doaj.art-2ef57e2e64044786ba85ee148241c8d8 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2024-04-24T06:55:16Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-2ef57e2e64044786ba85ee148241c8d82024-04-22T13:07:32ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-01151374410.15789/1563-0625-2013-1-37-4446ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDRENP. K. Iablonskiy0I. F. Dovgaljuk1A. A. Starshinova2O. A. Iakunova3ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» Минздрава России, Санкт-Петербург Санкт-Петербургский государственный университет, Санкт-ПетербургФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» Минздрава России, Санкт-ПетербургФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» Минздрава России, Санкт-ПетербургФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» Минздрава России, Санкт-ПетербургPresent study has revealed low diagnostic value of Mantoux test with 2 TE in detection of tuberculosis in MBT-infected children, thus requiring implementation of novel methods. Detectable activity of tuberculosis infection among observed children with low tuberculin sensitivity was found in 23.8% of cases, as revealed by Diaskin test, as compared to 42.7% cases in a group with moderate sensitivity to tuberculin. As shown by radiological data it was accompanied by enlargement of intrathoracic lymphatic nodes in 14.3% and 53.0% cases, respectively. The data obtained with Diaskin probe were confirmed by a reference QuantiFERON testing in 95% cases. Parameters of diagnostic value for Diaskin test are two-fold higher than for Mantoux test with 2 TE. Positivity for Diaskin test reflects activity of tuberculosis infection which is accompanied by clear clinical signs in 67.3% cases, and, in 80% cases, it ischaracterized by enlargement of intrathoracic lymphatic nodes as based on radiologic data, thus arranging a risk group for tuberculosis morbidity in children. Appropriate recommendations for these patients include a fullscale phthisiatric assessment and administration of well justified and adequate therapy.https://www.mimmun.ru/mimmun/article/view/47tuberculosischildrendiaskin testcomputer tomographydiagnostics |
| spellingShingle | P. K. Iablonskiy I. F. Dovgaljuk A. A. Starshinova O. A. Iakunova ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN Медицинская иммунология tuberculosis children diaskin test computer tomography diagnostics |
| title | ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN |
| title_full | ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN |
| title_fullStr | ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN |
| title_full_unstemmed | ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN |
| title_short | ROLE OF MODERN IMMUNOLOGIC TESTS IN DIAGNOSTICS OF TUBERCULOSIS IN CHILDREN |
| title_sort | role of modern immunologic tests in diagnostics of tuberculosis in children |
| topic | tuberculosis children diaskin test computer tomography diagnostics |
| url | https://www.mimmun.ru/mimmun/article/view/47 |
| work_keys_str_mv | AT pkiablonskiy roleofmodernimmunologictestsindiagnosticsoftuberculosisinchildren AT ifdovgaljuk roleofmodernimmunologictestsindiagnosticsoftuberculosisinchildren AT aastarshinova roleofmodernimmunologictestsindiagnosticsoftuberculosisinchildren AT oaiakunova roleofmodernimmunologictestsindiagnosticsoftuberculosisinchildren |