Immune Checkpoint Molecules—Inherited Variations as Markers for Cancer Risk

Immune Checkpoint Molecules—Inherited Variations as Markers for Cancer Risk

In recent years, immunotherapy has been revolutionized by a new approach that works by blocking receptors called immune checkpoints (IC). These molecules play a key role in maintaining immune homeostasis, mainly by suppressing the immune response and by preventing its overactivation. Since inhibitio...

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Bibliographic Details
Main Authors: Marta Wagner, Monika Jasek, Lidia Karabon
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint molecules
CTLA-4
PD-1/PD-L1
BTLA
TIM-3
LAG-3
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.606721/full

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