Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study
Preterm birth disrupts important neurodevelopmental processes occurring from mid-fetal to term-age. Musicotherapy, by enriching infants’ sensory input, might enhance brain maturation during this critical period of activity-dependent plasticity. To study the impact of music on preterm infants’ brain...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-06-01
|
| Series: | Developmental Cognitive Neuroscience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878929323000592 |
| _version_ | 1797802226505220096 |
|---|---|
| author | Joana Sa de Almeida Olivier Baud Sebastien Fau Francisca Barcos-Munoz Sebastien Courvoisier Lara Lordier François Lazeyras Petra S. Hüppi |
| author_facet | Joana Sa de Almeida Olivier Baud Sebastien Fau Francisca Barcos-Munoz Sebastien Courvoisier Lara Lordier François Lazeyras Petra S. Hüppi |
| author_sort | Joana Sa de Almeida |
| collection | DOAJ |
| description | Preterm birth disrupts important neurodevelopmental processes occurring from mid-fetal to term-age. Musicotherapy, by enriching infants’ sensory input, might enhance brain maturation during this critical period of activity-dependent plasticity. To study the impact of music on preterm infants’ brain structural changes, we recruited 54 very preterm infants randomized to receive or not a daily music intervention, that have undergone a longitudinal multi-shell diffusion MRI acquisition, before the intervention (at 33 weeks’ gestational age) and after it (at term-equivalent-age). Using whole-brain fixel-based (FBA) and NODDI analysis (n = 40), we showed a longitudinal increase of fiber cross-section (FC) and fiber density (FD) in all major cerebral white matter fibers. Regarding cortical grey matter, FD decreased while FC and orientation dispersion index (ODI) increased, reflecting intracortical multidirectional complexification and intracortical myelination. The music intervention resulted in a significantly higher longitudinal increase of FC and ODI in cortical paralimbic regions, namely the insulo-orbito-temporopolar complex, precuneus/posterior cingulate gyrus, as well as the auditory association cortex. Our results support a longitudinal early brain macro and microstructural maturation of white and cortical grey matter in preterm infants. The music intervention led to an increased intracortical complexity in regions important for socio-emotional development, known to be impaired in preterm infants. |
| first_indexed | 2024-03-13T05:02:53Z |
| format | Article |
| id | doaj.art-2ef817d0aa6344f583393f9a304bd9dd |
| institution | Directory Open Access Journal |
| issn | 1878-9293 |
| language | English |
| last_indexed | 2024-03-13T05:02:53Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Developmental Cognitive Neuroscience |
| spelling | doaj.art-2ef817d0aa6344f583393f9a304bd9dd2023-06-17T05:17:59ZengElsevierDevelopmental Cognitive Neuroscience1878-92932023-06-0161101254Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging studyJoana Sa de Almeida0Olivier Baud1Sebastien Fau2Francisca Barcos-Munoz3Sebastien Courvoisier4Lara Lordier5François Lazeyras6Petra S. Hüppi7Division of Development and Growth, Department of Paediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland; Corresponding author.Division of Neonatal and Intensive Care, Department of Paediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, SwitzerlandDivision of Neonatal and Intensive Care, Department of Paediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, SwitzerlandDivision of Neonatal and Intensive Care, Department of Paediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, SwitzerlandCenter of BioMedical Imaging (CIBM), University of Geneva, Geneva, Switzerland; Department of Radiology and Medical Informatics, Geneva, SwitzerlandDivision of Development and Growth, Department of Paediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, SwitzerlandCenter of BioMedical Imaging (CIBM), University of Geneva, Geneva, Switzerland; Department of Radiology and Medical Informatics, Geneva, SwitzerlandDivision of Development and Growth, Department of Paediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, SwitzerlandPreterm birth disrupts important neurodevelopmental processes occurring from mid-fetal to term-age. Musicotherapy, by enriching infants’ sensory input, might enhance brain maturation during this critical period of activity-dependent plasticity. To study the impact of music on preterm infants’ brain structural changes, we recruited 54 very preterm infants randomized to receive or not a daily music intervention, that have undergone a longitudinal multi-shell diffusion MRI acquisition, before the intervention (at 33 weeks’ gestational age) and after it (at term-equivalent-age). Using whole-brain fixel-based (FBA) and NODDI analysis (n = 40), we showed a longitudinal increase of fiber cross-section (FC) and fiber density (FD) in all major cerebral white matter fibers. Regarding cortical grey matter, FD decreased while FC and orientation dispersion index (ODI) increased, reflecting intracortical multidirectional complexification and intracortical myelination. The music intervention resulted in a significantly higher longitudinal increase of FC and ODI in cortical paralimbic regions, namely the insulo-orbito-temporopolar complex, precuneus/posterior cingulate gyrus, as well as the auditory association cortex. Our results support a longitudinal early brain macro and microstructural maturation of white and cortical grey matter in preterm infants. The music intervention led to an increased intracortical complexity in regions important for socio-emotional development, known to be impaired in preterm infants.http://www.sciencedirect.com/science/article/pii/S1878929323000592Diffusion MRIFixel-based analysisHuman preterm brain developmentMusic interventionNODDI |
| spellingShingle | Joana Sa de Almeida Olivier Baud Sebastien Fau Francisca Barcos-Munoz Sebastien Courvoisier Lara Lordier François Lazeyras Petra S. Hüppi Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study Developmental Cognitive Neuroscience Diffusion MRI Fixel-based analysis Human preterm brain development Music intervention NODDI |
| title | Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study |
| title_full | Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study |
| title_fullStr | Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study |
| title_full_unstemmed | Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study |
| title_short | Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study |
| title_sort | music impacts brain cortical microstructural maturation in very preterm infants a longitudinal diffusion mr imaging study |
| topic | Diffusion MRI Fixel-based analysis Human preterm brain development Music intervention NODDI |
| url | http://www.sciencedirect.com/science/article/pii/S1878929323000592 |
| work_keys_str_mv | AT joanasadealmeida musicimpactsbraincorticalmicrostructuralmaturationinverypreterminfantsalongitudinaldiffusionmrimagingstudy AT olivierbaud musicimpactsbraincorticalmicrostructuralmaturationinverypreterminfantsalongitudinaldiffusionmrimagingstudy AT sebastienfau musicimpactsbraincorticalmicrostructuralmaturationinverypreterminfantsalongitudinaldiffusionmrimagingstudy AT franciscabarcosmunoz musicimpactsbraincorticalmicrostructuralmaturationinverypreterminfantsalongitudinaldiffusionmrimagingstudy AT sebastiencourvoisier musicimpactsbraincorticalmicrostructuralmaturationinverypreterminfantsalongitudinaldiffusionmrimagingstudy AT laralordier musicimpactsbraincorticalmicrostructuralmaturationinverypreterminfantsalongitudinaldiffusionmrimagingstudy AT francoislazeyras musicimpactsbraincorticalmicrostructuralmaturationinverypreterminfantsalongitudinaldiffusionmrimagingstudy AT petrashuppi musicimpactsbraincorticalmicrostructuralmaturationinverypreterminfantsalongitudinaldiffusionmrimagingstudy |