Clinical-Epidemological Study of Cryptococcosis in Venezuela, 1994-2003
Cryptococcosis is an opportunistic disease of worldwide distribution. It is frequently an AIDS-defining infection. Antiretroviral treatment has reduced its occurrence. In Venezuela, the impact of this disease is unknown. The aim of this study is to describe the most relevant features of cryptococcos...
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| Format: | Article |
| Language: | English |
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2009-12-01
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| Series: | Kasmera |
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| Online Access: | https://produccioncientificaluz.org/index.php/kasmera/article/view/4846 |
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| author | Celina Pérez de Salazar Yumaira Hernández María Eugenia Guzmán Félix Arias Luzalba Nweihed María Eugenia Landaeta Rafael Borges Carlos Madera Arantza Roselló María Colella Claudia Hartung Sofía Mata Essayag |
| author_facet | Celina Pérez de Salazar Yumaira Hernández María Eugenia Guzmán Félix Arias Luzalba Nweihed María Eugenia Landaeta Rafael Borges Carlos Madera Arantza Roselló María Colella Claudia Hartung Sofía Mata Essayag |
| author_sort | Celina Pérez de Salazar |
| collection | DOAJ |
| description | Cryptococcosis is an opportunistic disease of worldwide distribution. It is frequently an AIDS-defining infection. Antiretroviral treatment has reduced its occurrence. In Venezuela, the impact of this disease is unknown. The aim of this study is to describe the most relevant features of cryptococcosis in our country. Methods: 110 clinical records with a diagnosis of cryptococcosis
hospitalized between 1994 and 2003 in 6 Venezuelan hospitals were analyzed. Data collected included demographic, clinical, diagnostic, therapeutic and outcome information. SPSS 10.0 software and EpiInfo 6, version 6.04 (2001) were used. Results: 110 patients with cryptococcosis were enrolled, including 17 autopsy protocols. One was 8 years old, the rest were over 15. Nineteen were female and 91 male; 91 (82.73%) had AIDS, 19 (17.27%) were HIV negative. Among the AIDS patients, average CD4+ count was < 200 cel/mm3 and viral load was > 30000 co pies/ml; 52 (57.14%) did not have other opportunistic infections or AIDS-related disease, and 39 (42.86%) had other associated conditions, such as tuberculosis (30.97%), PCP (28.21%) and toxoplasmosis (20.51%). In HIV negative patients, use of steroids (25%) was the predominant risk factor. Two patients were pregnant. 107 (57.27%) presented CNS infection; 12 (13.19%) with AIDS had cranial nerve alterations. Pulmonary disease was found in 4 (3.77%), of which one had AIDS. Cryptococcosis was an AIDS-defining infection in 61.54% of cases; 33 (30%) of the patients died. Conclusions: In most of the patients, cryptococcosis was associated with AIDS. In spite of the efficacy of antiretroviral treatment, this mycosis is still significant in Venezuela, perhaps due to late HIV infection diagnosis. |
| first_indexed | 2024-03-12T04:30:31Z |
| format | Article |
| id | doaj.art-2ef93c9c5125492aac5fb9a0cda73915 |
| institution | Directory Open Access Journal |
| issn | 0075-5222 2477-9628 |
| language | English |
| last_indexed | 2024-03-12T04:30:31Z |
| publishDate | 2009-12-01 |
| publisher | Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
| record_format | Article |
| series | Kasmera |
| spelling | doaj.art-2ef93c9c5125492aac5fb9a0cda739152023-09-03T10:04:58ZengUniversidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y TropicalesKasmera0075-52222477-96282009-12-0137214014724337Clinical-Epidemological Study of Cryptococcosis in Venezuela, 1994-2003Celina Pérez de Salazar0Yumaira Hernández1María Eugenia Guzmán2Félix Arias3Luzalba Nweihed4María Eugenia Landaeta5Rafael Borges6Carlos Madera7Arantza Roselló8María Colella9Claudia Hartung10Sofía Mata Essayag11Laboratorio de Micología, Facultad de Farmacia y Bioanálisis, Universidad de los Andes. Mérida. Venezuela.Sección de Micología Médica, Instituto de Medicina Tropical, Universidad Central de Venezuela.Hospital Miguel Pérez Carreño. Caracas. VenezuelaServicio de Enfermedades Infecciosas del Adulto, Hospital Universitario de Caracas.Cátedra de Microbiología, Escuela Luis Razetti, Universidad Central de VenezuelaCátedra de Microbiología, Escuela Luis Razetti, Universidad Central de VenezuelaInstituto de Biomedicina.Universidad Central de VenezuelaCátedra de Medicina Tropical, Escuela Luis Razetti, Universidad Central de VenezuelaSección de Micología Médica, Instituto de Medicina Tropical, Universidad Central de Venezuela.Sección de Micología Médica, Instituto de Medicina Tropical, Universidad Central de Venezuela.Sección de Micología Médica, Instituto de Medicina Tropical, Universidad Central de Venezuela.Sección de Micología Médica, Instituto de Medicina Tropical, Universidad Central de Venezuela.Cryptococcosis is an opportunistic disease of worldwide distribution. It is frequently an AIDS-defining infection. Antiretroviral treatment has reduced its occurrence. In Venezuela, the impact of this disease is unknown. The aim of this study is to describe the most relevant features of cryptococcosis in our country. Methods: 110 clinical records with a diagnosis of cryptococcosis hospitalized between 1994 and 2003 in 6 Venezuelan hospitals were analyzed. Data collected included demographic, clinical, diagnostic, therapeutic and outcome information. SPSS 10.0 software and EpiInfo 6, version 6.04 (2001) were used. Results: 110 patients with cryptococcosis were enrolled, including 17 autopsy protocols. One was 8 years old, the rest were over 15. Nineteen were female and 91 male; 91 (82.73%) had AIDS, 19 (17.27%) were HIV negative. Among the AIDS patients, average CD4+ count was < 200 cel/mm3 and viral load was > 30000 co pies/ml; 52 (57.14%) did not have other opportunistic infections or AIDS-related disease, and 39 (42.86%) had other associated conditions, such as tuberculosis (30.97%), PCP (28.21%) and toxoplasmosis (20.51%). In HIV negative patients, use of steroids (25%) was the predominant risk factor. Two patients were pregnant. 107 (57.27%) presented CNS infection; 12 (13.19%) with AIDS had cranial nerve alterations. Pulmonary disease was found in 4 (3.77%), of which one had AIDS. Cryptococcosis was an AIDS-defining infection in 61.54% of cases; 33 (30%) of the patients died. Conclusions: In most of the patients, cryptococcosis was associated with AIDS. In spite of the efficacy of antiretroviral treatment, this mycosis is still significant in Venezuela, perhaps due to late HIV infection diagnosis.https://produccioncientificaluz.org/index.php/kasmera/article/view/4846cryptococcus neoformanscriptococosisSIDAmeningoencefalitis |
| spellingShingle | Celina Pérez de Salazar Yumaira Hernández María Eugenia Guzmán Félix Arias Luzalba Nweihed María Eugenia Landaeta Rafael Borges Carlos Madera Arantza Roselló María Colella Claudia Hartung Sofía Mata Essayag Clinical-Epidemological Study of Cryptococcosis in Venezuela, 1994-2003 Kasmera cryptococcus neoformans criptococosis SIDA meningoencefalitis |
| title | Clinical-Epidemological Study of Cryptococcosis in Venezuela, 1994-2003 |
| title_full | Clinical-Epidemological Study of Cryptococcosis in Venezuela, 1994-2003 |
| title_fullStr | Clinical-Epidemological Study of Cryptococcosis in Venezuela, 1994-2003 |
| title_full_unstemmed | Clinical-Epidemological Study of Cryptococcosis in Venezuela, 1994-2003 |
| title_short | Clinical-Epidemological Study of Cryptococcosis in Venezuela, 1994-2003 |
| title_sort | clinical epidemological study of cryptococcosis in venezuela 1994 2003 |
| topic | cryptococcus neoformans criptococosis SIDA meningoencefalitis |
| url | https://produccioncientificaluz.org/index.php/kasmera/article/view/4846 |
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