A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach
Protontherapy (PT) is a fast-growing cancer therapy modality thanks to much-improved normal tissue sparing granted by the charged particles’ inverted dose-depth profile. Protons, however, exhibit a low biological effectiveness at clinically relevant energies. To enhance PT efficacy and counteract ca...
| Автори: | , , , , , , , , , |
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| Формат: | Стаття |
| Мова: | English |
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MDPI AG
2021-12-01
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| Серія: | Applied Sciences |
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| Онлайн доступ: | https://www.mdpi.com/2076-3417/11/24/11986 |
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| author | Valerio Ricciardi Pavel Bláha Raffaele Buompane Giuseppina Crescente Giacomo Cuttone Lucio Gialanella Katarina Michaličková Severina Pacifico Giuseppe Porzio Lorenzo Manti |
| author_facet | Valerio Ricciardi Pavel Bláha Raffaele Buompane Giuseppina Crescente Giacomo Cuttone Lucio Gialanella Katarina Michaličková Severina Pacifico Giuseppe Porzio Lorenzo Manti |
| author_sort | Valerio Ricciardi |
| collection | DOAJ |
| description | Protontherapy (PT) is a fast-growing cancer therapy modality thanks to much-improved normal tissue sparing granted by the charged particles’ inverted dose-depth profile. Protons, however, exhibit a low biological effectiveness at clinically relevant energies. To enhance PT efficacy and counteract cancer radioresistance, Proton–Boron Capture Therapy (PBCT) was recently proposed. PBCT exploits the highly DNA-damaging α-particles generated by the p + <sup>11</sup>B→3α (pB) nuclear reaction, whose cross-section peaks for proton energies of 675 keV. Although a significant enhancement of proton biological effectiveness by PBCT has been demonstrated for high-energy proton beams, validation of the PBCT rationale using monochromatic proton beams having energy close to the reaction cross-section maximum is still lacking. To this end, we implemented a novel setup for radiobiology experiments at a 3-MV tandem accelerator; using a scattering chamber equipped with an Au foil scatterer for beam diffusion on the biological sample, uniformity in energy and fluence with uncertainties of 2% and 5%, respectively, was achieved. Human cancer cells were irradiated at this beamline for the first time with 685-keV protons. The measured enhancement in cancer cell killing due to the <sup>11</sup>B carrier BSH was the highest among those thus far observed, thereby corroborating the mechanistic bases of PBCT. |
| first_indexed | 2024-03-10T04:36:25Z |
| format | Article |
| id | doaj.art-2ef97e5c878e4d6d9dae96e564a85a33 |
| institution | Directory Open Access Journal |
| issn | 2076-3417 |
| language | English |
| last_indexed | 2024-03-10T04:36:25Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Applied Sciences |
| spelling | doaj.art-2ef97e5c878e4d6d9dae96e564a85a332023-11-23T03:41:28ZengMDPI AGApplied Sciences2076-34172021-12-0111241198610.3390/app112411986A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy ApproachValerio Ricciardi0Pavel Bláha1Raffaele Buompane2Giuseppina Crescente3Giacomo Cuttone4Lucio Gialanella5Katarina Michaličková6Severina Pacifico7Giuseppe Porzio8Lorenzo Manti9Istituto Nazionale di Fisica Nucleare (INFN)—Sezione di Napoli, 80126 Napoli, ItalyIstituto Nazionale di Fisica Nucleare (INFN)—Sezione di Napoli, 80126 Napoli, ItalyIstituto Nazionale di Fisica Nucleare (INFN)—Sezione di Napoli, 80126 Napoli, ItalyDipartimento di Scienze e Tecnologie Ambientali Biologiche e Farmaceutiche, Università della Campania “Luigi Vanvitelli”, 81100 Caserta, ItalyLaboratori Nazionali del Sud (LNS)-INFN, 95123 Catania, ItalyIstituto Nazionale di Fisica Nucleare (INFN)—Sezione di Napoli, 80126 Napoli, ItalyIstituto Nazionale di Fisica Nucleare (INFN)—Sezione di Napoli, 80126 Napoli, ItalyIstituto Nazionale di Fisica Nucleare (INFN)—Sezione di Napoli, 80126 Napoli, ItalyIstituto Nazionale di Fisica Nucleare (INFN)—Sezione di Napoli, 80126 Napoli, ItalyIstituto Nazionale di Fisica Nucleare (INFN)—Sezione di Napoli, 80126 Napoli, ItalyProtontherapy (PT) is a fast-growing cancer therapy modality thanks to much-improved normal tissue sparing granted by the charged particles’ inverted dose-depth profile. Protons, however, exhibit a low biological effectiveness at clinically relevant energies. To enhance PT efficacy and counteract cancer radioresistance, Proton–Boron Capture Therapy (PBCT) was recently proposed. PBCT exploits the highly DNA-damaging α-particles generated by the p + <sup>11</sup>B→3α (pB) nuclear reaction, whose cross-section peaks for proton energies of 675 keV. Although a significant enhancement of proton biological effectiveness by PBCT has been demonstrated for high-energy proton beams, validation of the PBCT rationale using monochromatic proton beams having energy close to the reaction cross-section maximum is still lacking. To this end, we implemented a novel setup for radiobiology experiments at a 3-MV tandem accelerator; using a scattering chamber equipped with an Au foil scatterer for beam diffusion on the biological sample, uniformity in energy and fluence with uncertainties of 2% and 5%, respectively, was achieved. Human cancer cells were irradiated at this beamline for the first time with 685-keV protons. The measured enhancement in cancer cell killing due to the <sup>11</sup>B carrier BSH was the highest among those thus far observed, thereby corroborating the mechanistic bases of PBCT.https://www.mdpi.com/2076-3417/11/24/11986protontherapyProton-Boron Capture Therapy (PBCT)Proton-Boron Fusion-Enhanced Protontherapy (PBFEPT)BSHlow-energy protonsalpha particles |
| spellingShingle | Valerio Ricciardi Pavel Bláha Raffaele Buompane Giuseppina Crescente Giacomo Cuttone Lucio Gialanella Katarina Michaličková Severina Pacifico Giuseppe Porzio Lorenzo Manti A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach Applied Sciences protontherapy Proton-Boron Capture Therapy (PBCT) Proton-Boron Fusion-Enhanced Protontherapy (PBFEPT) BSH low-energy protons alpha particles |
| title | A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach |
| title_full | A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach |
| title_fullStr | A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach |
| title_full_unstemmed | A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach |
| title_short | A New Low-Energy Proton Irradiation Facility to Unveil the Mechanistic Basis of the Proton-Boron Capture Therapy Approach |
| title_sort | new low energy proton irradiation facility to unveil the mechanistic basis of the proton boron capture therapy approach |
| topic | protontherapy Proton-Boron Capture Therapy (PBCT) Proton-Boron Fusion-Enhanced Protontherapy (PBFEPT) BSH low-energy protons alpha particles |
| url | https://www.mdpi.com/2076-3417/11/24/11986 |
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