Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus
Abstract Patients with Parkinson’s disease often complain of excessive daytime sleepiness which negatively impacts their quality of life. The pedunculopontine nucleus, proposed as a target for deep brain stimulation to improve freezing of gait in Parkinson’s disease, is also known to play a key role...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-023-00455-7 |
| _version_ | 1797641664874938368 |
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| author | Aurélie Davin Stéphan Chabardès Annaelle Devergnas Caroline Benstaali Claire-Anne N. Gutekunst Olivier David Napoléon Torres-Martinez Brigitte Piallat |
| author_facet | Aurélie Davin Stéphan Chabardès Annaelle Devergnas Caroline Benstaali Claire-Anne N. Gutekunst Olivier David Napoléon Torres-Martinez Brigitte Piallat |
| author_sort | Aurélie Davin |
| collection | DOAJ |
| description | Abstract Patients with Parkinson’s disease often complain of excessive daytime sleepiness which negatively impacts their quality of life. The pedunculopontine nucleus, proposed as a target for deep brain stimulation to improve freezing of gait in Parkinson’s disease, is also known to play a key role in the arousal system. Thus, the putative control of excessive daytime sleepiness by pedunculopontine nucleus area stimulation merits exploration for treating Parkinson’s disease patients. To this end, two adult nonhuman primates (macaca fascicularis) received a deep brain stimulation electrode implanted into the pedunculopontine nucleus area along with a polysomnographic equipment. Stimulation at low frequencies and high frequencies was studied, in healthy and then MPTP-treated nonhuman primates. Here, we observed that MPTP-treated nonhuman primates suffered from excessive daytime sleepiness and that low-frequency stimulation of the pedunculopontine nucleus area was effective in reducing daytime sleepiness. Indeed, low-frequency stimulation of the pedunculopontine nucleus area induced a significant increase in sleep onset latency, longer continuous periods of wakefulness and thus, a partially restored daytime wake architecture. These findings may contribute to the development of new therapeutic strategies in patients suffering from excessive daytime sleepiness. |
| first_indexed | 2024-03-11T13:48:57Z |
| format | Article |
| id | doaj.art-2ef9e4e88d264bf3987872265c88fc13 |
| institution | Directory Open Access Journal |
| issn | 2373-8057 |
| language | English |
| last_indexed | 2024-03-11T13:48:57Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj.art-2ef9e4e88d264bf3987872265c88fc132023-11-02T09:30:13ZengNature Portfolionpj Parkinson's Disease2373-80572023-01-019111210.1038/s41531-023-00455-7Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleusAurélie Davin0Stéphan Chabardès1Annaelle Devergnas2Caroline Benstaali3Claire-Anne N. Gutekunst4Olivier David5Napoléon Torres-Martinez6Brigitte Piallat7Univ. Grenoble Alpes, CEA, LETI, ClinatecUniv. Grenoble Alpes, CEA, LETI, ClinatecYerkes National Primate Research CenterUniv. Grenoble Alpes, Inserm, U1216, Grenoble Institut NeurosciencesEmory University School of MedicineUniv. Grenoble Alpes, Inserm, U1216, Grenoble Institut NeurosciencesUniv. Grenoble Alpes, CEA, LETI, ClinatecUniv. Grenoble Alpes, Inserm, U1216, Grenoble Institut NeurosciencesAbstract Patients with Parkinson’s disease often complain of excessive daytime sleepiness which negatively impacts their quality of life. The pedunculopontine nucleus, proposed as a target for deep brain stimulation to improve freezing of gait in Parkinson’s disease, is also known to play a key role in the arousal system. Thus, the putative control of excessive daytime sleepiness by pedunculopontine nucleus area stimulation merits exploration for treating Parkinson’s disease patients. To this end, two adult nonhuman primates (macaca fascicularis) received a deep brain stimulation electrode implanted into the pedunculopontine nucleus area along with a polysomnographic equipment. Stimulation at low frequencies and high frequencies was studied, in healthy and then MPTP-treated nonhuman primates. Here, we observed that MPTP-treated nonhuman primates suffered from excessive daytime sleepiness and that low-frequency stimulation of the pedunculopontine nucleus area was effective in reducing daytime sleepiness. Indeed, low-frequency stimulation of the pedunculopontine nucleus area induced a significant increase in sleep onset latency, longer continuous periods of wakefulness and thus, a partially restored daytime wake architecture. These findings may contribute to the development of new therapeutic strategies in patients suffering from excessive daytime sleepiness.https://doi.org/10.1038/s41531-023-00455-7 |
| spellingShingle | Aurélie Davin Stéphan Chabardès Annaelle Devergnas Caroline Benstaali Claire-Anne N. Gutekunst Olivier David Napoléon Torres-Martinez Brigitte Piallat Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus npj Parkinson's Disease |
| title | Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus |
| title_full | Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus |
| title_fullStr | Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus |
| title_full_unstemmed | Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus |
| title_short | Excessive daytime sleepiness in a model of Parkinson’s disease improved by low-frequency stimulation of the pedunculopontine nucleus |
| title_sort | excessive daytime sleepiness in a model of parkinson s disease improved by low frequency stimulation of the pedunculopontine nucleus |
| url | https://doi.org/10.1038/s41531-023-00455-7 |
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