The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women.
High susceptibility of the African population to develop cardiovascular disease obliges us to investigate possible contributing risk factors. Our aim was to determine whether low 25(OH)D status is associated with increased blood pressure and carotid-radial pulse wave velocity in black South African...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3552848?pdf=render |
| _version_ | 1811333563723808768 |
|---|---|
| author | Iolanthé M Kruger Marlena C Kruger Colleen M Doak Aletta E Schutte Hugo W Huisman Johannes M Van Rooyen Rudolph Schutte Leoné Malan Nicolaas T Malan Carla M T Fourie Annamarie Kruger |
| author_facet | Iolanthé M Kruger Marlena C Kruger Colleen M Doak Aletta E Schutte Hugo W Huisman Johannes M Van Rooyen Rudolph Schutte Leoné Malan Nicolaas T Malan Carla M T Fourie Annamarie Kruger |
| author_sort | Iolanthé M Kruger |
| collection | DOAJ |
| description | High susceptibility of the African population to develop cardiovascular disease obliges us to investigate possible contributing risk factors. Our aim was to determine whether low 25(OH)D status is associated with increased blood pressure and carotid-radial pulse wave velocity in black South African women. We studied 291 urban women (mean age: 57.56±9.00 yrs.). 25(OH)D status was determined by serum 25(OH)D levels. Women were stratified into sufficient (>30 ng/ml), and insufficient/deficient (<30 ng/ml) groups. Cardiovascular variables were compared between groups. Women with low 25(OH)D levels had significantly higher SBP (150.8±27.1 vs. 137.6±21.0), DBP (94.7±14.5 vs. 89.3±12.3) and PP (53.15(50.7;55.7) vs. 46.3(29.4;84.6)) compared to women with sufficient levels. No significant difference was observed with regards to c-rPWV. ANCOVA analyses still revealed significant differences between the two groups with regards to SBP, DBP as well as PP. Partial correlations revealed significant inverse association between SBP and 25(OH)D (p = .04;r = -.12). Women with low 25(OH)D levels were ∼2 times more likely to have high SBP (95% CI: 3.23;1.05). To conclude, women with deficient/insufficient 25(OH)D had significantly higher SBP compared to women with a sufficient 25(OH) status. |
| first_indexed | 2024-04-13T16:54:50Z |
| format | Article |
| id | doaj.art-2efa26548a38432a877bf42c8665fb66 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T16:54:50Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2efa26548a38432a877bf42c8665fb662022-12-22T02:38:51ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5455410.1371/journal.pone.0054554The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women.Iolanthé M KrugerMarlena C KrugerColleen M DoakAletta E SchutteHugo W HuismanJohannes M Van RooyenRudolph SchutteLeoné MalanNicolaas T MalanCarla M T FourieAnnamarie KrugerHigh susceptibility of the African population to develop cardiovascular disease obliges us to investigate possible contributing risk factors. Our aim was to determine whether low 25(OH)D status is associated with increased blood pressure and carotid-radial pulse wave velocity in black South African women. We studied 291 urban women (mean age: 57.56±9.00 yrs.). 25(OH)D status was determined by serum 25(OH)D levels. Women were stratified into sufficient (>30 ng/ml), and insufficient/deficient (<30 ng/ml) groups. Cardiovascular variables were compared between groups. Women with low 25(OH)D levels had significantly higher SBP (150.8±27.1 vs. 137.6±21.0), DBP (94.7±14.5 vs. 89.3±12.3) and PP (53.15(50.7;55.7) vs. 46.3(29.4;84.6)) compared to women with sufficient levels. No significant difference was observed with regards to c-rPWV. ANCOVA analyses still revealed significant differences between the two groups with regards to SBP, DBP as well as PP. Partial correlations revealed significant inverse association between SBP and 25(OH)D (p = .04;r = -.12). Women with low 25(OH)D levels were ∼2 times more likely to have high SBP (95% CI: 3.23;1.05). To conclude, women with deficient/insufficient 25(OH)D had significantly higher SBP compared to women with a sufficient 25(OH) status.http://europepmc.org/articles/PMC3552848?pdf=render |
| spellingShingle | Iolanthé M Kruger Marlena C Kruger Colleen M Doak Aletta E Schutte Hugo W Huisman Johannes M Van Rooyen Rudolph Schutte Leoné Malan Nicolaas T Malan Carla M T Fourie Annamarie Kruger The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women. PLoS ONE |
| title | The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women. |
| title_full | The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women. |
| title_fullStr | The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women. |
| title_full_unstemmed | The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women. |
| title_short | The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women. |
| title_sort | association of 25 oh d with blood pressure pulse pressure and carotid radial pulse wave velocity in african women |
| url | http://europepmc.org/articles/PMC3552848?pdf=render |
| work_keys_str_mv | AT iolanthemkruger theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT marlenackruger theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT colleenmdoak theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT alettaeschutte theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT hugowhuisman theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT johannesmvanrooyen theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT rudolphschutte theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT leonemalan theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT nicolaastmalan theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT carlamtfourie theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT annamariekruger theassociationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT iolanthemkruger associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT marlenackruger associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT colleenmdoak associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT alettaeschutte associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT hugowhuisman associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT johannesmvanrooyen associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT rudolphschutte associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT leonemalan associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT nicolaastmalan associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT carlamtfourie associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen AT annamariekruger associationof25ohdwithbloodpressurepulsepressureandcarotidradialpulsewavevelocityinafricanwomen |