Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms
The association between intraductal papillary mucinous neoplasms (IPMNs) and extra-pancreatic malignancies is controversial. This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age- and gender-matched controls without known IPMNs who underwent esophag...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/12/2127 |
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| author | Dana Zelnik Yovel Erwin Santo Majd Khader Roie Tzadok Nir Bar Asaf Aizic Oren Shibolet Dana Ben-Ami Shor |
| author_facet | Dana Zelnik Yovel Erwin Santo Majd Khader Roie Tzadok Nir Bar Asaf Aizic Oren Shibolet Dana Ben-Ami Shor |
| author_sort | Dana Zelnik Yovel |
| collection | DOAJ |
| description | The association between intraductal papillary mucinous neoplasms (IPMNs) and extra-pancreatic malignancies is controversial. This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age- and gender-matched controls without known IPMNs who underwent esophagogastroduodenoscopies (EGDs) for similar clinical reasons. The presence of gastric and esophageal cancer, Barrett’s esophagus, neuroendocrine tumors (NETs), gastrointestinal stromal tumors (GISTs), gastric adenomas, and ampullary tumors was assessed. The results showed that 4/340 (1.2%) of the IPMN patients had gastric cancer and 1/340 (0.3%) had esophageal cancer. The matched control group had a similar incidence of gastric cancer (5/340) (1.5%), with no esophageal cancer cases (<i>p</i> > 0.999). The overall incidence of other esophagogastroduodenal conditions did not significantly differ between the IPMN patients and the controls. However, the incidence of gastric cancer in the IPMN patients was higher than expected based on national cancer registry data (standardized incidence ratio of 31.39; <i>p</i> < 0.001; CI 8.38–78.76). In conclusion, IPMN patients have a significantly higher incidence of gastric cancer compared to the general population. However, the incidence of esophagogastroduodenal findings, including gastric and esophageal cancer, is similar between IPMN patients and those who undergo an EGD for similar clinical indications. Further research is needed to determine optimal surveillance strategies for IPMN patients regarding their risk of developing gastric cancer. |
| first_indexed | 2024-03-11T02:34:31Z |
| format | Article |
| id | doaj.art-2efe1da3ca1849a49c9c04ad0bf34b4a |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T02:34:31Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2efe1da3ca1849a49c9c04ad0bf34b4a2023-11-18T10:01:27ZengMDPI AGDiagnostics2075-44182023-06-011312212710.3390/diagnostics13122127Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous NeoplasmsDana Zelnik Yovel0Erwin Santo1Majd Khader2Roie Tzadok3Nir Bar4Asaf Aizic5Oren Shibolet6Dana Ben-Ami Shor7The Kamila Gonczarowski Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, Zerifin 703000, IsraelDepartment of Gastroenterology, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6423906, IsraelThe association between intraductal papillary mucinous neoplasms (IPMNs) and extra-pancreatic malignancies is controversial. This cross-sectional study compared esophagogastroduodenal findings in 340 IPMN patients to those of age- and gender-matched controls without known IPMNs who underwent esophagogastroduodenoscopies (EGDs) for similar clinical reasons. The presence of gastric and esophageal cancer, Barrett’s esophagus, neuroendocrine tumors (NETs), gastrointestinal stromal tumors (GISTs), gastric adenomas, and ampullary tumors was assessed. The results showed that 4/340 (1.2%) of the IPMN patients had gastric cancer and 1/340 (0.3%) had esophageal cancer. The matched control group had a similar incidence of gastric cancer (5/340) (1.5%), with no esophageal cancer cases (<i>p</i> > 0.999). The overall incidence of other esophagogastroduodenal conditions did not significantly differ between the IPMN patients and the controls. However, the incidence of gastric cancer in the IPMN patients was higher than expected based on national cancer registry data (standardized incidence ratio of 31.39; <i>p</i> < 0.001; CI 8.38–78.76). In conclusion, IPMN patients have a significantly higher incidence of gastric cancer compared to the general population. However, the incidence of esophagogastroduodenal findings, including gastric and esophageal cancer, is similar between IPMN patients and those who undergo an EGD for similar clinical indications. Further research is needed to determine optimal surveillance strategies for IPMN patients regarding their risk of developing gastric cancer.https://www.mdpi.com/2075-4418/13/12/2127intraductal papillary mucinous neoplasms (IPMNs)gastric canceresophageal cancer |
| spellingShingle | Dana Zelnik Yovel Erwin Santo Majd Khader Roie Tzadok Nir Bar Asaf Aizic Oren Shibolet Dana Ben-Ami Shor Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms Diagnostics intraductal papillary mucinous neoplasms (IPMNs) gastric cancer esophageal cancer |
| title | Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms |
| title_full | Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms |
| title_fullStr | Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms |
| title_full_unstemmed | Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms |
| title_short | Esophagogastroduodenal Findings in Patients with Intraductal Papillary Mucinous Neoplasms |
| title_sort | esophagogastroduodenal findings in patients with intraductal papillary mucinous neoplasms |
| topic | intraductal papillary mucinous neoplasms (IPMNs) gastric cancer esophageal cancer |
| url | https://www.mdpi.com/2075-4418/13/12/2127 |
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