New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina
Chemical investigation of the endophytic fungus Botryosphaeria australis isolated from Avicennia marina originally from Hainan Province, P.R. China, yielded a new compound botryosphaenin (1), from the class of napthoquinone, together with 5 known compounds, botryosterpene (2) and 5-hydroxy-2,7-dimet...
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| Format: | Article |
| Language: | English |
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Kementerian Kelautan dan Perikanan
2013-12-01
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| Series: | Squalen |
| Subjects: | |
| Online Access: | http://bbp4b.litbang.kkp.go.id/squalen-bulletin/index.php/squalen/article/view/86 |
| _version_ | 1811271769992986624 |
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| author | Robert A. Bara Ilka Zerfaß Daowan Lai Weihan Lin Abdessamad Debbab Heike Brötz-Oesterelt Peter Proksch |
| author_facet | Robert A. Bara Ilka Zerfaß Daowan Lai Weihan Lin Abdessamad Debbab Heike Brötz-Oesterelt Peter Proksch |
| author_sort | Robert A. Bara |
| collection | DOAJ |
| description | Chemical investigation of the endophytic fungus Botryosphaeria australis isolated from Avicennia marina originally from Hainan Province, P.R. China, yielded a new compound botryosphaenin (1), from the class of napthoquinone, together with 5 known compounds, botryosterpene (2) and 5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (3) and its derivatives, 6-ethyl-5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (4), O-methylaspmenone (5), O-methylasparvenone (6) and 5-(carboxymethyl)-7-hydroxy-1,4a-dimethyl-6-methylene decahydron aphthalene-1-carboxylic acid (7). Their structures were determined on the basis of spectroscopic methods including 1D (1H, 13C, and DEPT) and 2D (COSY, HMQC, HMBC, and ROESY) NMR experiments and by mass spectroscopic measurements The new compounds, 1 showed activity against the bacterial pathogens Staphylococcus aureus, several Streptococcus species and Bacillus subtilis, but also against the eukaryotic cell lines THP-1 (human leukemia monocyte) and BALB/3T3 (mouse embryonic fibroblast). |
| first_indexed | 2024-04-12T22:27:01Z |
| format | Article |
| id | doaj.art-2efead30226246d3b051f9bf8fed61db |
| institution | Directory Open Access Journal |
| issn | 2089-5690 2406-9272 |
| language | English |
| last_indexed | 2024-04-12T22:27:01Z |
| publishDate | 2013-12-01 |
| publisher | Kementerian Kelautan dan Perikanan |
| record_format | Article |
| series | Squalen |
| spelling | doaj.art-2efead30226246d3b051f9bf8fed61db2022-12-22T03:14:06ZengKementerian Kelautan dan PerikananSqualen2089-56902406-92722013-12-018313914510.15578/squalen.v8i3.8663New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marinaRobert A. Bara0Ilka Zerfaß1Daowan Lai2Weihan Lin3Abdessamad Debbab4Heike Brötz-Oesterelt5Peter Proksch6Institut für Pharmazeutische Biologie und Biotechnologie Heinrich-Heine-Universität Düsseldorf Universitätsstr, Geb.26.23. D-40225 Düsseldorf, Germany Faculty of Fisheries and Marine Science, Sam Ratulangi University, Kampus Unsrat, Bahu Manado 95115, IndonesiaInstitut für Pharmazeutische Biologie und Biotechnologie Heinrich-Heine-Universität Düsseldorf Universitätsstr, Geb.26.23. D-40225 Düsseldorf, GermanyInstitut für Pharmazeutische Biologie und Biotechnologie Heinrich-Heine-Universität Düsseldorf Universitätsstr, Geb.26.23. D-40225 Düsseldorf, GermanyNational Research Laboratories of Natural and Biomimetic Drugs, Peking University, Health Science Center, 100083 Beijing, People’s Republic of ChinaInstitut für Pharmazeutische Biologie und Biotechnologie Heinrich-Heine-Universität Düsseldorf Universitätsstr, Geb.26.23. D-40225 Düsseldorf, GermanyInstitut für Pharmazeutische Biologie und Biotechnologie Heinrich-Heine-Universität Düsseldorf Universitätsstr, Geb.26.23. D-40225 Düsseldorf, GermanyInstitut für Pharmazeutische Biologie und Biotechnologie Heinrich-Heine-Universität Düsseldorf Universitätsstr, Geb.26.23. D-40225 Düsseldorf, GermanyChemical investigation of the endophytic fungus Botryosphaeria australis isolated from Avicennia marina originally from Hainan Province, P.R. China, yielded a new compound botryosphaenin (1), from the class of napthoquinone, together with 5 known compounds, botryosterpene (2) and 5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (3) and its derivatives, 6-ethyl-5-hydroxy-2,7-dimethoxynaphthalene-1,4-dione (4), O-methylaspmenone (5), O-methylasparvenone (6) and 5-(carboxymethyl)-7-hydroxy-1,4a-dimethyl-6-methylene decahydron aphthalene-1-carboxylic acid (7). Their structures were determined on the basis of spectroscopic methods including 1D (1H, 13C, and DEPT) and 2D (COSY, HMQC, HMBC, and ROESY) NMR experiments and by mass spectroscopic measurements The new compounds, 1 showed activity against the bacterial pathogens Staphylococcus aureus, several Streptococcus species and Bacillus subtilis, but also against the eukaryotic cell lines THP-1 (human leukemia monocyte) and BALB/3T3 (mouse embryonic fibroblast).http://bbp4b.litbang.kkp.go.id/squalen-bulletin/index.php/squalen/article/view/86MangroveAvicennia marinaBotryosphaeria australisantibiotic activitiescytotoxicity |
| spellingShingle | Robert A. Bara Ilka Zerfaß Daowan Lai Weihan Lin Abdessamad Debbab Heike Brötz-Oesterelt Peter Proksch New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina Squalen Mangrove Avicennia marina Botryosphaeria australis antibiotic activities cytotoxicity |
| title | New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina |
| title_full | New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina |
| title_fullStr | New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina |
| title_full_unstemmed | New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina |
| title_short | New Natural Product from Botryosphaeria australis, an Endophyte from Mangrove Avicennia marina |
| title_sort | new natural product from botryosphaeria australis an endophyte from mangrove avicennia marina |
| topic | Mangrove Avicennia marina Botryosphaeria australis antibiotic activities cytotoxicity |
| url | http://bbp4b.litbang.kkp.go.id/squalen-bulletin/index.php/squalen/article/view/86 |
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