Radiotherapy Advances in Pediatric Neuro-Oncology
Radiation therapy (RT) represents an integral component in the treatment of many pediatric brain tumors. Multiple advances have emerged within pediatric radiation oncology that aim to optimize the therapeutic ratio—improving disease control while limiting RT-related toxicity. These include...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-11-01
|
| Series: | Bioengineering |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-5354/5/4/97 |
| _version_ | 1797709324411207680 |
|---|---|
| author | Ethan B. Ludmir David R. Grosshans Kristina D. Woodhouse |
| author_facet | Ethan B. Ludmir David R. Grosshans Kristina D. Woodhouse |
| author_sort | Ethan B. Ludmir |
| collection | DOAJ |
| description | Radiation therapy (RT) represents an integral component in the treatment of many pediatric brain tumors. Multiple advances have emerged within pediatric radiation oncology that aim to optimize the therapeutic ratio—improving disease control while limiting RT-related toxicity. These include innovations in treatment planning with magnetic resonance imaging (MRI) simulation, as well as increasingly sophisticated radiation delivery techniques. Advanced RT techniques, including photon-based RT such as intensity-modulated RT (IMRT) and volumetric-modulated arc therapy (VMAT), as well as particle beam therapy and stereotactic RT, have afforded an array of options to dramatically reduce radiation exposure of uninvolved normal tissues while treating target volumes. Along with advances in image guidance of radiation treatments, novel RT approaches are being implemented in ongoing and future prospective clinical trials. As the era of molecular risk stratification unfolds, personalization of radiation dose, target, and technique holds the promise to meaningfully improve outcomes for pediatric neuro-oncology patients. |
| first_indexed | 2024-03-12T06:34:50Z |
| format | Article |
| id | doaj.art-2eff61a1e6ee4b6d8bd674f35b8e64c9 |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-12T06:34:50Z |
| publishDate | 2018-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-2eff61a1e6ee4b6d8bd674f35b8e64c92023-09-03T01:21:47ZengMDPI AGBioengineering2306-53542018-11-01549710.3390/bioengineering5040097bioengineering5040097Radiotherapy Advances in Pediatric Neuro-OncologyEthan B. Ludmir0David R. Grosshans1Kristina D. Woodhouse2Department of Radiation Oncology, Unit 97, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USADepartment of Radiation Oncology, Unit 97, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USADepartment of Radiation Oncology, Unit 97, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USARadiation therapy (RT) represents an integral component in the treatment of many pediatric brain tumors. Multiple advances have emerged within pediatric radiation oncology that aim to optimize the therapeutic ratio—improving disease control while limiting RT-related toxicity. These include innovations in treatment planning with magnetic resonance imaging (MRI) simulation, as well as increasingly sophisticated radiation delivery techniques. Advanced RT techniques, including photon-based RT such as intensity-modulated RT (IMRT) and volumetric-modulated arc therapy (VMAT), as well as particle beam therapy and stereotactic RT, have afforded an array of options to dramatically reduce radiation exposure of uninvolved normal tissues while treating target volumes. Along with advances in image guidance of radiation treatments, novel RT approaches are being implemented in ongoing and future prospective clinical trials. As the era of molecular risk stratification unfolds, personalization of radiation dose, target, and technique holds the promise to meaningfully improve outcomes for pediatric neuro-oncology patients.https://www.mdpi.com/2306-5354/5/4/97radiotherapypediatric oncologybrain tumorsproton beam therapyintensity-modulated radiotherapymagnetic resonance imagingimage guidance |
| spellingShingle | Ethan B. Ludmir David R. Grosshans Kristina D. Woodhouse Radiotherapy Advances in Pediatric Neuro-Oncology Bioengineering radiotherapy pediatric oncology brain tumors proton beam therapy intensity-modulated radiotherapy magnetic resonance imaging image guidance |
| title | Radiotherapy Advances in Pediatric Neuro-Oncology |
| title_full | Radiotherapy Advances in Pediatric Neuro-Oncology |
| title_fullStr | Radiotherapy Advances in Pediatric Neuro-Oncology |
| title_full_unstemmed | Radiotherapy Advances in Pediatric Neuro-Oncology |
| title_short | Radiotherapy Advances in Pediatric Neuro-Oncology |
| title_sort | radiotherapy advances in pediatric neuro oncology |
| topic | radiotherapy pediatric oncology brain tumors proton beam therapy intensity-modulated radiotherapy magnetic resonance imaging image guidance |
| url | https://www.mdpi.com/2306-5354/5/4/97 |
| work_keys_str_mv | AT ethanbludmir radiotherapyadvancesinpediatricneurooncology AT davidrgrosshans radiotherapyadvancesinpediatricneurooncology AT kristinadwoodhouse radiotherapyadvancesinpediatricneurooncology |