Serum sTWEAK and FGF-23 Levels in Hemodialysis and Renal Transplant Patients
Background: Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Objective: To evaluate the changes in serum soluble TNF-like weak inducer of apoptosis (sTWEAK) and fibroblast growth factor 23 (FGF-23) in hemodialysis (HD) patients and renal transplant recipi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2017-04-01
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| Series: | International Journal of Organ Transplantation Medicine |
| Subjects: | |
| Online Access: | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/338 |
| _version_ | 1818991261968760832 |
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| author | H Eskandari Naji A Ghorbanihaghjo H Argani S Raeisi J Safa AH Alirezaei N Rashtchizadeh |
| author_facet | H Eskandari Naji A Ghorbanihaghjo H Argani S Raeisi J Safa AH Alirezaei N Rashtchizadeh |
| author_sort | H Eskandari Naji |
| collection | DOAJ |
| description | Background: Kidney transplantation is the treatment of choice for patients with end-stage renal disease.
Objective: To evaluate the changes in serum soluble TNF-like weak inducer of apoptosis (sTWEAK) and fibroblast growth factor 23 (FGF-23) in hemodialysis (HD) patients and renal transplant recipients (RTR).
Methods: Serum samples were obtained from 30 patients on chronic HD, 30 RTRs, and 30 normal controls. Biochemical factors, sTWEAK, FGF-23, and interleukin-6 (IL-6) were measured by standard methods.
Results: Serum levels of sTWEAK in RTRs were significantly higher than those in the HD patients (p=0.025); RTR and HD patients had significantly lower sTWEAK levels than the controls (p=0.001 and p= 0.038, respectively). Serum levels of FGF-23 in HD patients were significantly (p=0.001) higher than those in the RTR; the level was higher in both studied groups compared to that in the controls (p=0.001 for both groups). The mean serum level of IL-6 in HD was significantly higher than that in RTR patients (p=0.013). IL-6 levels in both groups were significantly higher than those in controls (p=0.001 and p= 0.012, respectively). In HD group a negative correlation was found between FGF-23 and sTWEAK (r= ?0.375, p=0.041); there were also a significant correlation between FGF-23 and IL-6 (r= 0.480, p= 0.007) and between IL-6 and sTWEAK (r= ?0.409, p=0.025).
Conclusion: We found that serum sTWEAK is decreased and FGF-23 is increased in HD and RTR groups comparing with the control group. However, further studies are needed to shed light over their direct role on atherosclerosis and cardiovascular outcomes. |
| first_indexed | 2024-12-20T20:07:28Z |
| format | Article |
| id | doaj.art-2effb8508a4c4b129828d22aa68e124d |
| institution | Directory Open Access Journal |
| issn | 2008-6482 2008-6490 |
| language | English |
| last_indexed | 2024-12-20T20:07:28Z |
| publishDate | 2017-04-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Organ Transplantation Medicine |
| spelling | doaj.art-2effb8508a4c4b129828d22aa68e124d2022-12-21T19:27:54ZengShiraz University of Medical SciencesInternational Journal of Organ Transplantation Medicine2008-64822008-64902017-04-0182243Serum sTWEAK and FGF-23 Levels in Hemodialysis and Renal Transplant PatientsH Eskandari Naji0A Ghorbanihaghjo1H Argani2S Raeisi3J Safa4AH Alirezaei5N Rashtchizadeh6Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, Iran and Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Urology, Shahid Modarres Hospital, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranDivision of Clinical Laboratory, Children�s Hospital, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Urology, Shahid Modarres Hospital, Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranBiotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IranBackground: Kidney transplantation is the treatment of choice for patients with end-stage renal disease. Objective: To evaluate the changes in serum soluble TNF-like weak inducer of apoptosis (sTWEAK) and fibroblast growth factor 23 (FGF-23) in hemodialysis (HD) patients and renal transplant recipients (RTR). Methods: Serum samples were obtained from 30 patients on chronic HD, 30 RTRs, and 30 normal controls. Biochemical factors, sTWEAK, FGF-23, and interleukin-6 (IL-6) were measured by standard methods. Results: Serum levels of sTWEAK in RTRs were significantly higher than those in the HD patients (p=0.025); RTR and HD patients had significantly lower sTWEAK levels than the controls (p=0.001 and p= 0.038, respectively). Serum levels of FGF-23 in HD patients were significantly (p=0.001) higher than those in the RTR; the level was higher in both studied groups compared to that in the controls (p=0.001 for both groups). The mean serum level of IL-6 in HD was significantly higher than that in RTR patients (p=0.013). IL-6 levels in both groups were significantly higher than those in controls (p=0.001 and p= 0.012, respectively). In HD group a negative correlation was found between FGF-23 and sTWEAK (r= ?0.375, p=0.041); there were also a significant correlation between FGF-23 and IL-6 (r= 0.480, p= 0.007) and between IL-6 and sTWEAK (r= ?0.409, p=0.025). Conclusion: We found that serum sTWEAK is decreased and FGF-23 is increased in HD and RTR groups comparing with the control group. However, further studies are needed to shed light over their direct role on atherosclerosis and cardiovascular outcomes.http://www.ijotm.com/ojs/index.php/IJOTM/article/view/338Renal dialysisTL1 cytokine [Supplementary Concept]sTWEAKKidney transplantationFibroblast growth factor 23 [Supplementary Concept] |
| spellingShingle | H Eskandari Naji A Ghorbanihaghjo H Argani S Raeisi J Safa AH Alirezaei N Rashtchizadeh Serum sTWEAK and FGF-23 Levels in Hemodialysis and Renal Transplant Patients International Journal of Organ Transplantation Medicine Renal dialysis TL1 cytokine [Supplementary Concept] sTWEAK Kidney transplantation Fibroblast growth factor 23 [Supplementary Concept] |
| title | Serum sTWEAK and FGF-23 Levels in Hemodialysis and Renal Transplant Patients |
| title_full | Serum sTWEAK and FGF-23 Levels in Hemodialysis and Renal Transplant Patients |
| title_fullStr | Serum sTWEAK and FGF-23 Levels in Hemodialysis and Renal Transplant Patients |
| title_full_unstemmed | Serum sTWEAK and FGF-23 Levels in Hemodialysis and Renal Transplant Patients |
| title_short | Serum sTWEAK and FGF-23 Levels in Hemodialysis and Renal Transplant Patients |
| title_sort | serum stweak and fgf 23 levels in hemodialysis and renal transplant patients |
| topic | Renal dialysis TL1 cytokine [Supplementary Concept] sTWEAK Kidney transplantation Fibroblast growth factor 23 [Supplementary Concept] |
| url | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/338 |
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