Evaluation of the Analgesic Efficacy of Undiluted Intraperitoneal and Incisional Ropivacaine for Postoperative Analgesia in Dogs after Major Abdominal Surgery
Recommendations for intraperitoneal (IP) and incisional (INC) administration of local anaesthetics after visceral surgery exist, but evidence is scarce. This prospective, randomized, blinded, controlled, clinical trial compared postoperative pain in dogs undergoing major abdominal surgery. Sixteen c...
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MDPI AG
2023-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/13/9/1489 |
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| author | Inken S. Henze Victoria Navarro Altuna Joëlle I. Steiger Paul R. Torgerson Annette P. N. Kutter |
| author_facet | Inken S. Henze Victoria Navarro Altuna Joëlle I. Steiger Paul R. Torgerson Annette P. N. Kutter |
| author_sort | Inken S. Henze |
| collection | DOAJ |
| description | Recommendations for intraperitoneal (IP) and incisional (INC) administration of local anaesthetics after visceral surgery exist, but evidence is scarce. This prospective, randomized, blinded, controlled, clinical trial compared postoperative pain in dogs undergoing major abdominal surgery. Sixteen client-owned dogs were anaesthetized with a standardized balanced protocol including opioids and received either 2 mg/kg ropivacaine IP (0.27 mL/kg) and a 1 mg/kg INC splash (0.13 mL/kg) or equal volumes of saline. Influence of the treatment on heart rate (HR) and postoperative pain was assessed using the Short Form of the Glasgow Composite Pain Scale (GCPS-SF), a dynamic interactive visual analogue scale (DIVAS) and mechanical nociceptive threshold testing (MNT). Data was tested with mixed ordinal regression and log linear mixed models for 0.5, 1, 2, 3, 4, 6, 8, 10 and 12 h after extubation. Rescue analgesia was given to 3/8 dogs after ropivacaine and 0/8 dogs after saline. GCPS-SF and MNT were not different between groups. DIVAS was slightly higher after ropivacaine (odds increased by 5.44 (confidence interval (CI) 1.17–9.96, <i>p</i> = 0.012)), and HR after ropivacaine was 0.76 * that after saline (CI 0.61–0.96, <i>p</i> = 0.02) with no effect of time (<i>p</i> = 0.1). Undiluted ropivacaine IP and INC was not beneficial for postoperative analgesia. |
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| language | English |
| last_indexed | 2024-03-11T04:24:55Z |
| publishDate | 2023-04-01 |
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| series | Animals |
| spelling | doaj.art-2effe399cafc4004ba492cf1e19e8c5b2023-11-17T22:29:49ZengMDPI AGAnimals2076-26152023-04-01139148910.3390/ani13091489Evaluation of the Analgesic Efficacy of Undiluted Intraperitoneal and Incisional Ropivacaine for Postoperative Analgesia in Dogs after Major Abdominal SurgeryInken S. Henze0Victoria Navarro Altuna1Joëlle I. Steiger2Paul R. Torgerson3Annette P. N. Kutter4Section of Anaesthesiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandSection of Anaesthesiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandSection of Anaesthesiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandSection of Epidemiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandSection of Anaesthesiology, Vetsuisse Faculty, University of Zurich, 8057 Zurich, SwitzerlandRecommendations for intraperitoneal (IP) and incisional (INC) administration of local anaesthetics after visceral surgery exist, but evidence is scarce. This prospective, randomized, blinded, controlled, clinical trial compared postoperative pain in dogs undergoing major abdominal surgery. Sixteen client-owned dogs were anaesthetized with a standardized balanced protocol including opioids and received either 2 mg/kg ropivacaine IP (0.27 mL/kg) and a 1 mg/kg INC splash (0.13 mL/kg) or equal volumes of saline. Influence of the treatment on heart rate (HR) and postoperative pain was assessed using the Short Form of the Glasgow Composite Pain Scale (GCPS-SF), a dynamic interactive visual analogue scale (DIVAS) and mechanical nociceptive threshold testing (MNT). Data was tested with mixed ordinal regression and log linear mixed models for 0.5, 1, 2, 3, 4, 6, 8, 10 and 12 h after extubation. Rescue analgesia was given to 3/8 dogs after ropivacaine and 0/8 dogs after saline. GCPS-SF and MNT were not different between groups. DIVAS was slightly higher after ropivacaine (odds increased by 5.44 (confidence interval (CI) 1.17–9.96, <i>p</i> = 0.012)), and HR after ropivacaine was 0.76 * that after saline (CI 0.61–0.96, <i>p</i> = 0.02) with no effect of time (<i>p</i> = 0.1). Undiluted ropivacaine IP and INC was not beneficial for postoperative analgesia.https://www.mdpi.com/2076-2615/13/9/1489anaesthesiaanalgesiacaninecompanion animalslaparotomylocoregional |
| spellingShingle | Inken S. Henze Victoria Navarro Altuna Joëlle I. Steiger Paul R. Torgerson Annette P. N. Kutter Evaluation of the Analgesic Efficacy of Undiluted Intraperitoneal and Incisional Ropivacaine for Postoperative Analgesia in Dogs after Major Abdominal Surgery Animals anaesthesia analgesia canine companion animals laparotomy locoregional |
| title | Evaluation of the Analgesic Efficacy of Undiluted Intraperitoneal and Incisional Ropivacaine for Postoperative Analgesia in Dogs after Major Abdominal Surgery |
| title_full | Evaluation of the Analgesic Efficacy of Undiluted Intraperitoneal and Incisional Ropivacaine for Postoperative Analgesia in Dogs after Major Abdominal Surgery |
| title_fullStr | Evaluation of the Analgesic Efficacy of Undiluted Intraperitoneal and Incisional Ropivacaine for Postoperative Analgesia in Dogs after Major Abdominal Surgery |
| title_full_unstemmed | Evaluation of the Analgesic Efficacy of Undiluted Intraperitoneal and Incisional Ropivacaine for Postoperative Analgesia in Dogs after Major Abdominal Surgery |
| title_short | Evaluation of the Analgesic Efficacy of Undiluted Intraperitoneal and Incisional Ropivacaine for Postoperative Analgesia in Dogs after Major Abdominal Surgery |
| title_sort | evaluation of the analgesic efficacy of undiluted intraperitoneal and incisional ropivacaine for postoperative analgesia in dogs after major abdominal surgery |
| topic | anaesthesia analgesia canine companion animals laparotomy locoregional |
| url | https://www.mdpi.com/2076-2615/13/9/1489 |
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