The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update
Globally in 2020, an estimated ~600,000 women were diagnosed with and 340,000 women died from cervical cancer. Compared to 2012, the number of cases increased by 7.5% and the number of deaths increased by 17%. MiRNAs are involved in multiple processes in the pathogenesis of cervical cancer. Dysregul...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/13/7126 |
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| author | Pui-Wah Choi Tin Lun Liu Chun Wai Wong Sze Kei Liu Yick-Liang Lum Wai-Kit Ming |
| author_facet | Pui-Wah Choi Tin Lun Liu Chun Wai Wong Sze Kei Liu Yick-Liang Lum Wai-Kit Ming |
| author_sort | Pui-Wah Choi |
| collection | DOAJ |
| description | Globally in 2020, an estimated ~600,000 women were diagnosed with and 340,000 women died from cervical cancer. Compared to 2012, the number of cases increased by 7.5% and the number of deaths increased by 17%. MiRNAs are involved in multiple processes in the pathogenesis of cervical cancer. Dysregulation of miRNAs in the pre-stage of cervical cancer is the focus of this review. Here we summarize the dysregulated miRNAs in clinical samples from cervical pre-cancer patients and relate them to the early transformation process owing to human papillomavirus (HPV) infection in the cervical cells. When HPV infects the normal cervical cells, the DNA damage response is initiated with the involvement of HPV’s E1 and E2 proteins. Later, cell proliferation and cell death are affected by the E6 and E7 proteins. We find that the expressions of miRNAs in cervical pre-cancerous tissue revealed by different studies seldom agreed with each other. The discrepancy in sample types, samples’ HPV status, expression measurement, and methods for analysis contributed to the non-aligned results across studies. However, several miRNAs (miR-34a, miR-9, miR-21, miR-145, and miR-375) were found to be dysregulated across multiple studies. In addition, there are hints that the DNA damage response and cell growth response induced by HPV during the early transformation of the cervical cells are related to these miRNAs. Currently, no review articles analyse the relationship between the dysregulated miRNAs in cervical pre-cancerous tissue and their possible roles in the early processes involving HPV’s protein encoded by the early genes and DNA damage response during normal cell transformation. Our review provides insight on spotting miRNAs involved in the early pathogenic processes and pointing out their potential as biomarker targets of cervical pre-cancer. |
| first_indexed | 2024-03-09T21:49:39Z |
| format | Article |
| id | doaj.art-2f03d130540041d0b2beb7a3b2ad5fbd |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:49:39Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2f03d130540041d0b2beb7a3b2ad5fbd2023-11-23T20:08:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-06-012313712610.3390/ijms23137126The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An UpdatePui-Wah Choi0Tin Lun Liu1Chun Wai Wong2Sze Kei Liu3Yick-Liang Lum4Wai-Kit Ming5Department of Research and Development, WomenX Biotech Limited, Hong Kong Science and Technology Park, Tai Po, Hong KongInternational School, Jinan University, Guangzhou 510632, ChinaDepartment of Research and Development, WomenX Biotech Limited, Hong Kong Science and Technology Park, Tai Po, Hong KongDepartment of Research and Development, WomenX Biotech Limited, Hong Kong Science and Technology Park, Tai Po, Hong KongDepartment of Research and Development, WomenX Biotech Limited, Hong Kong Science and Technology Park, Tai Po, Hong KongDepartment of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong KongGlobally in 2020, an estimated ~600,000 women were diagnosed with and 340,000 women died from cervical cancer. Compared to 2012, the number of cases increased by 7.5% and the number of deaths increased by 17%. MiRNAs are involved in multiple processes in the pathogenesis of cervical cancer. Dysregulation of miRNAs in the pre-stage of cervical cancer is the focus of this review. Here we summarize the dysregulated miRNAs in clinical samples from cervical pre-cancer patients and relate them to the early transformation process owing to human papillomavirus (HPV) infection in the cervical cells. When HPV infects the normal cervical cells, the DNA damage response is initiated with the involvement of HPV’s E1 and E2 proteins. Later, cell proliferation and cell death are affected by the E6 and E7 proteins. We find that the expressions of miRNAs in cervical pre-cancerous tissue revealed by different studies seldom agreed with each other. The discrepancy in sample types, samples’ HPV status, expression measurement, and methods for analysis contributed to the non-aligned results across studies. However, several miRNAs (miR-34a, miR-9, miR-21, miR-145, and miR-375) were found to be dysregulated across multiple studies. In addition, there are hints that the DNA damage response and cell growth response induced by HPV during the early transformation of the cervical cells are related to these miRNAs. Currently, no review articles analyse the relationship between the dysregulated miRNAs in cervical pre-cancerous tissue and their possible roles in the early processes involving HPV’s protein encoded by the early genes and DNA damage response during normal cell transformation. Our review provides insight on spotting miRNAs involved in the early pathogenic processes and pointing out their potential as biomarker targets of cervical pre-cancer.https://www.mdpi.com/1422-0067/23/13/7126cervical pre-cancermicroRNAcervical cancerbiomarkersCINSIL |
| spellingShingle | Pui-Wah Choi Tin Lun Liu Chun Wai Wong Sze Kei Liu Yick-Liang Lum Wai-Kit Ming The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update International Journal of Molecular Sciences cervical pre-cancer microRNA cervical cancer biomarkers CIN SIL |
| title | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
| title_full | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
| title_fullStr | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
| title_full_unstemmed | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
| title_short | The Dysregulation of MicroRNAs in the Development of Cervical Pre-Cancer—An Update |
| title_sort | dysregulation of micrornas in the development of cervical pre cancer an update |
| topic | cervical pre-cancer microRNA cervical cancer biomarkers CIN SIL |
| url | https://www.mdpi.com/1422-0067/23/13/7126 |
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