Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in children
ObjectiveTo investigate the associations between intrapartum antibiotic prophylaxis of group B streptococcus (GBS) in pregnant women and the risk of food allergy in Chinese childrenDesignRetrospective cohort study of 2,909 mother-child pairs.SettingTaixing People's Hospital in Eastern China.Par...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1039900/full |
| _version_ | 1811213142204612608 |
|---|---|
| author | Hong Zhang Kang Xu Zhihui Liu Yuanmei Shi Hui Li Xiaoping Yin |
| author_facet | Hong Zhang Kang Xu Zhihui Liu Yuanmei Shi Hui Li Xiaoping Yin |
| author_sort | Hong Zhang |
| collection | DOAJ |
| description | ObjectiveTo investigate the associations between intrapartum antibiotic prophylaxis of group B streptococcus (GBS) in pregnant women and the risk of food allergy in Chinese childrenDesignRetrospective cohort study of 2,909 mother-child pairs.SettingTaixing People's Hospital in Eastern China.ParticipantsTerm infants born 2018–2019, followed longitudinally from birth to 3 years.ExposuresThe GBS-IAP was defined as therapy with intravenous penicillin G or ampicillin or cefazolin ≥4 h prior to delivery to the mother. Reference infants were defined as born without or with other intrapartum antibiotic exposure.MethodsTo investigate the incidence information of food allergy in children aged 18 months and three years old. Kaplan-Meier survival analysis and log-rank tests were used to evaluate the cumulative incidence in the group with GBS-IAP and the group without GBS-IAP. Cox proportional hazards models were conducted to determine the univariate and multivariate association between maternal GBS-IAP and incident food allergy after various covariates were adjusted.ResultsThe cumulative incidence of food allergy in the group with GBS-IAP was higher than that in the group without GBS-IAP in children under 18 months old (8.1% vs. 4.5%, P = 0.005, log-rank test), but no significant differences were observed in children under three years old (9.2% vs. 7.0%, P = 0.146, log-rank test). The univariate cox proportional hazards model in children under 18 months old revealed that children in the GBS-IAP group had faster food allergy development when compared with children in the group without GBS-IAP (HR.: 1.887,95% CI: 1.207–2.950, P = 0.005), so was the multivariate model (HR.: 1.906,95% CI: 1.158–3.137, P = 0.011). However, both univariate (HR: 1.343, 95% CI: 0.891∼2.026, P = 0.159) and multivariate (HR: 1.253, 95%CI: 0.796∼1.972, P = 0.329) cox proportional hazards model in children under three years old showed no significant differences between children in the group with GBS-IAP and group without GBS-IAP.ConclusionIntrapartum antibiotic prophylaxis of group B streptococcus may increase the cumulative incidence and risk of food allergy in children under 18 months old, but it had no significant effect on children under three years old. |
| first_indexed | 2024-04-12T05:40:48Z |
| format | Article |
| id | doaj.art-2f0aad96661b46e88929fcd78b36acdd |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T05:40:48Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-2f0aad96661b46e88929fcd78b36acdd2022-12-22T03:45:39ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-12-011010.3389/fped.2022.10399001039900Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in childrenHong Zhang0Kang Xu1Zhihui Liu2Yuanmei Shi3Hui Li4Xiaoping Yin5Department of Pediatrics,Taixing People's Hospital, Taizhou, Jiangsu, ChinaDepartment of Pediatrics,Taixing People's Hospital, Taizhou, Jiangsu, ChinaSchool of Clinical Medicine, Bengbu Medical College, Bengbu, Anhui, ChinaDepartment of Pediatrics,Taixing People's Hospital, Taizhou, Jiangsu, ChinaDepartment of Pediatrics,Taixing People's Hospital, Taizhou, Jiangsu, ChinaDepartment of Pediatrics,Taixing People's Hospital, Taizhou, Jiangsu, ChinaObjectiveTo investigate the associations between intrapartum antibiotic prophylaxis of group B streptococcus (GBS) in pregnant women and the risk of food allergy in Chinese childrenDesignRetrospective cohort study of 2,909 mother-child pairs.SettingTaixing People's Hospital in Eastern China.ParticipantsTerm infants born 2018–2019, followed longitudinally from birth to 3 years.ExposuresThe GBS-IAP was defined as therapy with intravenous penicillin G or ampicillin or cefazolin ≥4 h prior to delivery to the mother. Reference infants were defined as born without or with other intrapartum antibiotic exposure.MethodsTo investigate the incidence information of food allergy in children aged 18 months and three years old. Kaplan-Meier survival analysis and log-rank tests were used to evaluate the cumulative incidence in the group with GBS-IAP and the group without GBS-IAP. Cox proportional hazards models were conducted to determine the univariate and multivariate association between maternal GBS-IAP and incident food allergy after various covariates were adjusted.ResultsThe cumulative incidence of food allergy in the group with GBS-IAP was higher than that in the group without GBS-IAP in children under 18 months old (8.1% vs. 4.5%, P = 0.005, log-rank test), but no significant differences were observed in children under three years old (9.2% vs. 7.0%, P = 0.146, log-rank test). The univariate cox proportional hazards model in children under 18 months old revealed that children in the GBS-IAP group had faster food allergy development when compared with children in the group without GBS-IAP (HR.: 1.887,95% CI: 1.207–2.950, P = 0.005), so was the multivariate model (HR.: 1.906,95% CI: 1.158–3.137, P = 0.011). However, both univariate (HR: 1.343, 95% CI: 0.891∼2.026, P = 0.159) and multivariate (HR: 1.253, 95%CI: 0.796∼1.972, P = 0.329) cox proportional hazards model in children under three years old showed no significant differences between children in the group with GBS-IAP and group without GBS-IAP.ConclusionIntrapartum antibiotic prophylaxis of group B streptococcus may increase the cumulative incidence and risk of food allergy in children under 18 months old, but it had no significant effect on children under three years old.https://www.frontiersin.org/articles/10.3389/fped.2022.1039900/fullgroup b streptococcusintrapartum antibiotic prophylaxisfood allergygroup b streptococcuschildren |
| spellingShingle | Hong Zhang Kang Xu Zhihui Liu Yuanmei Shi Hui Li Xiaoping Yin Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in children Frontiers in Pediatrics group b streptococcus intrapartum antibiotic prophylaxis food allergy group b streptococcus children |
| title | Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in children |
| title_full | Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in children |
| title_fullStr | Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in children |
| title_full_unstemmed | Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in children |
| title_short | Study on the relationship between intrapartum group B streptococcus prophylaxis and food allergy in children |
| title_sort | study on the relationship between intrapartum group b streptococcus prophylaxis and food allergy in children |
| topic | group b streptococcus intrapartum antibiotic prophylaxis food allergy group b streptococcus children |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1039900/full |
| work_keys_str_mv | AT hongzhang studyontherelationshipbetweenintrapartumgroupbstreptococcusprophylaxisandfoodallergyinchildren AT kangxu studyontherelationshipbetweenintrapartumgroupbstreptococcusprophylaxisandfoodallergyinchildren AT zhihuiliu studyontherelationshipbetweenintrapartumgroupbstreptococcusprophylaxisandfoodallergyinchildren AT yuanmeishi studyontherelationshipbetweenintrapartumgroupbstreptococcusprophylaxisandfoodallergyinchildren AT huili studyontherelationshipbetweenintrapartumgroupbstreptococcusprophylaxisandfoodallergyinchildren AT xiaopingyin studyontherelationshipbetweenintrapartumgroupbstreptococcusprophylaxisandfoodallergyinchildren |