Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients
In the past decade, stroke incidence in younger adults increased. Methionine synthase reductase (MTRR) A66G polymorphism is one of the risk factors for ischemic stroke (IS). However, clinical features of IS in MTRR A66G polymorphism are not yet studied.Objective: to investigate clinical features of...
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| Format: | Article |
| Language: | Russian |
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IMA-PRESS LLC
2021-08-01
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| Series: | Неврология, нейропсихиатрия, психосоматика |
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| Online Access: | https://nnp.ima-press.net/nnp/article/view/1627 |
| _version_ | 1827062766443167744 |
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| author | O. V. Tsyganenko L. I. Volkova A. M. Alasheev |
| author_facet | O. V. Tsyganenko L. I. Volkova A. M. Alasheev |
| author_sort | O. V. Tsyganenko |
| collection | DOAJ |
| description | In the past decade, stroke incidence in younger adults increased. Methionine synthase reductase (MTRR) A66G polymorphism is one of the risk factors for ischemic stroke (IS). However, clinical features of IS in MTRR A66G polymorphism are not yet studied.Objective: to investigate clinical features of IS in MTRR A66G polymorphism.Patients and methods. One hundred forty-one younger patients with IS, hospitalized in the neurological department of Sverdlovsk Regional Clinical Hospital №1, were included in the study. MTRR A66G polymorphism was detected by the real-time polymerase chain reaction in all participants.Results and discussion. MTRR A66G polymorphism was present in 83.7% of younger patients with IS. Participants with MTRR A66G polymorphism had a significantly higher prevalence of arterial hypertension (р=0.029). In addition, protein C level was significantly lower in patients with MTRR A66G mutation (р=0.001).Conclusion. The majority of younger patients with IS have MTRR A66G polymorphism. Therefore, the inclusion of MTRR A66G polymorphism screening in the diagnostic algorithm of stroke in young adults seems necessary. |
| first_indexed | 2024-04-10T02:00:37Z |
| format | Article |
| id | doaj.art-2f0b36b698cb4d7792aaadf91a42a30c |
| institution | Directory Open Access Journal |
| issn | 2074-2711 2310-1342 |
| language | Russian |
| last_indexed | 2025-02-18T20:01:09Z |
| publishDate | 2021-08-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Неврология, нейропсихиатрия, психосоматика |
| spelling | doaj.art-2f0b36b698cb4d7792aaadf91a42a30c2024-10-17T16:15:28ZrusIMA-PRESS LLCНеврология, нейропсихиатрия, психосоматика2074-27112310-13422021-08-01134252910.14412/2074-2711-2021-4-25-291159Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patientsO. V. Tsyganenko0L. I. Volkova1A. M. Alasheev2Sverdlovsk Regional Clinical Hospital №1Sverdlovsk Regional Clinical Hospital №1; Department of Nervous System Diseases, Neurosurgery, and Medical Genetics, Ural State Medical University, Ministry of Health of RussiaSverdlovsk Regional Clinical Hospital №1In the past decade, stroke incidence in younger adults increased. Methionine synthase reductase (MTRR) A66G polymorphism is one of the risk factors for ischemic stroke (IS). However, clinical features of IS in MTRR A66G polymorphism are not yet studied.Objective: to investigate clinical features of IS in MTRR A66G polymorphism.Patients and methods. One hundred forty-one younger patients with IS, hospitalized in the neurological department of Sverdlovsk Regional Clinical Hospital №1, were included in the study. MTRR A66G polymorphism was detected by the real-time polymerase chain reaction in all participants.Results and discussion. MTRR A66G polymorphism was present in 83.7% of younger patients with IS. Participants with MTRR A66G polymorphism had a significantly higher prevalence of arterial hypertension (р=0.029). In addition, protein C level was significantly lower in patients with MTRR A66G mutation (р=0.001).Conclusion. The majority of younger patients with IS have MTRR A66G polymorphism. Therefore, the inclusion of MTRR A66G polymorphism screening in the diagnostic algorithm of stroke in young adults seems necessary.https://nnp.ima-press.net/nnp/article/view/1627ischemic stroke in young adultsarterial hypertensionprotein cmethionine synthase reductase a66g |
| spellingShingle | O. V. Tsyganenko L. I. Volkova A. M. Alasheev Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients Неврология, нейропсихиатрия, психосоматика ischemic stroke in young adults arterial hypertension protein c methionine synthase reductase a66g |
| title | Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients |
| title_full | Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients |
| title_fullStr | Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients |
| title_full_unstemmed | Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients |
| title_short | Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients |
| title_sort | methionine synthase reductase a66g polymorphism and ischemic stroke in younger patients |
| topic | ischemic stroke in young adults arterial hypertension protein c methionine synthase reductase a66g |
| url | https://nnp.ima-press.net/nnp/article/view/1627 |
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